Postdoctoral positions to study the Hippo pathway

Peter MacCallum Cancer Centre is the largest cancer research group in Australia, uniquely integrating basic, translational and clinical research with patient care in the setting of a specialist cancer hospital.

You will be part of the Cell Growth and Proliferation Laboratory, led by Dr Kieran Harvey, which is investigating organ size-control and tumorigenesis controlled by the Salvador-Warts-Hippo (SWH) pathway. The focus of your research will involve determining the mechanism by which activity of the SWH pathway is controlled, and how this pathway controls tissue growth and tumorigenesis.

Skills required include a PhD, with a broad base of molecular, genetic and cell biology techniques. You will have the ability to teach and supervise undergraduate and postgraduate students, and technical staff. You have a strong background in cell signalling with an emphasis on signal transduction pathways and molecular mechanisms regulating cell proliferation and growth. Experience with Drosophila will be advantageous but is not essential.

Selected References:

CLC Poon, JI Lin, X Zhang and KF Harvey (2011). The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway. Dev Cell. 21: 896-90

X Zhang, J George, S Deb, JL Degoutin, EA Takano, SB Fox, AOCS Study Group, DDL Bowtell and KF Harvey (2011). The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene. Oncogene. 30: 2810-2822.

X Zhang, CC Milton, CLC Poon, W Hong and KF Harvey (2011). Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway. Cell Death Diff. 18: 1346-1355.

FC Bennett and KF Harvey (2006). Fat Cadherin Modulates Organ Size in Drosophila via the Salvador/Warts/Hippo Signaling Pathway. Curr Biol. 16, 2101-2110.
Enquiries to: Dr Kieran Harvey: Kieran.Harvey[at]petermac.org

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