Closing Date: 15 March 2021
We seek a candidate for a Wellcome Trust-funded Research Associate position working on an interdisciplinary project investigating the role of cell shape in controlling asymmetric cell divisions, fate decisions and tissue morphogenesis. This project is based in the laboratory of Dr Shane Herbert (University of Manchester, UK) and builds upon our recent work revealing that asymmetric divisions fundamentally coordinate tissue morphogenesis during blood vessel formation (Costa. G., et. al. 2016. Nat. Cell Biol. and unpublished work). In particular, we aim to determine how and why acquisition of specific interphase cell geometries modifies the biomechanics of cell division to trigger asymmetric divisions, both during blood vessel formation and development of other tissues. Using in vitro micropatterning to modulate cell shape, omics techniques and live cell imaging approaches, both in vitro and in vivo during zebrafish embryonic development, we aim to define how cell shape globally impacts cellular transcription, translation, actomyosin dynamics, chromosome segregation and DNA damage to drive asymmetric division in diverse tissue contexts in vivo.
The successful applicant will already hold (or have nearly completed) a PhD in a relevant discipline and have experience of either live cell imaging, the mechanisms of cell division, micropatterning tools and/or the zebrafish model system.
The position is available from 1st April 2020 and is tenable for up to 60 months full time (later start dates are negotiable). For more details of the laboratory, please see www.herbertlab.com.
Informal enquiries can be made to Dr. S. Herbert.
Tel: 0161 275 1140
Application forms and further particulars can be obtained at http://www.manchester.ac.uk/aboutus/jobs/