the community site for and by developmental biologists

Displaying posts with the tag: is_archive [Clear Filter]

Moving neuromuscular disorders research forward: from novel models to clinical studies

Posted by on February 27th, 2020

This Editorial by Maaike van Putten, Julija Hmeljak, Annemieke Aartsma-Rus and James J. Dowling was recently published in Development’s sister journal Disease Models & Mechanisms, announcing a new Special Issue. Neuromuscular disorders (NMDs) encompass a diverse group of genetic diseases characterized by loss of muscle functionality. Despite extensive efforts to develop therapies, no curative treatment[…]

The people behind the papers – Roman Szabo and Thomas Bugge

Posted by on January 29th, 2020

This interview, the 74th in our series, was recently published in Development.  Dysregulated activity of cell surface proteolytic enzymes has a wide range of developmental and pathological consequences, but the underlying mechanisms are often poorly understood. A new Development paper uses mice to model a severe inherited form of enteropathy and the role of the serine protease matriptase[…]

Obituary: Jarema Malicki (1965-2019)

Posted by on March 6th, 2019

This obituary by Colin Johnson recently appeared in Development. Jarema Malicki, a pioneer in developmental studies of the vertebrate retina, died on 4th January 2019, shortly after being diagnosed with cancer. Here, I reflect on Jarema’s life and work, with a particular focus on his research interests in zebrafish as a model organism for vertebrate[…]

Post Doctoral Associate in the Rieger Lab

Posted by on December 18th, 2018

The Rieger lab is searching for a postdoctoral scholar in the Biology Department at the University of Miami. The postdoctoral scholar will be working on mechanisms of chemotherapy-induced peripheral neuropathy using primarily zebrafish as a model system. Chemotherapy-induced peripheral neuropathy is a side effect of chemotherapy that affects 60-70% of patients for which currently no[…]

The Curious Case of Protocadherin 19 Epilepsy

Posted by on March 12th, 2018

Daniel Pederick & Paul Thomas Comment on our paper: Pederick, et al. 2018. Abnormal Cell Sorting Underlies the Unique X-Linked Inheritance of PCDH19 Epilepsy. Neuron 97 (1).   Here we discuss the curious case of female-restricted epilepsy, an unusual disorder caused by mutations in the Protocadherin 19 (PCDH19) gene. How changes in this cell adhesion[…]