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Preventing cellular mixing with programmed cell death

Posted by on February 12th, 2020

By Lisandro Maya-Ramos and Takashi Mikawa Bilaterality, the property of having two symmetrical sides, is widely conserved among animals. It is estimated that 99% of all animal species are bilaterians, with the remaining 1% composed by sponges and radial animals, which lack or have radial symmetry respectively (1).  Although bilaterality is widespread among animals, little[…]

The people behind the papers – Masanori Abe and Reiko Kuroda

Posted by on June 19th, 2019

This interview, the 64th in our series, was recently published in Development One of the most obvious examples of left-right asymmetry in animal bodies comes from snails: in most species or strains, the shells coil dextrally, but some coil sinistrally. The control of coiling is genetic and begins in the early embryo. Previous work has implicated the[…]

The people behind the papers – Guillaume Blin, Manuel Thery & Sally Lowell

Posted by on September 21st, 2018

During early mouse development, a series of signalling interactions breaks the symmetry of the egg cylinder, spatially organising the embryo into territories that define the future axes of the body. Symmetry breaking can also be observed in embryonic stem cell (ESC) colonies cultured on micropatterned substrates, which thus provide a powerful system to test the[…]