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The people behind the papers: Ehsan Pourkarimi & Iestyn Whitehouse

Posted by on January 25th, 2017

How does a developing embryo coordinate DNA replication with gene transcription? This fundamental question is the focus of today’s paper, recently published in eLife. We caught up with lead author Ehsan Pourkarimi and his supervisor Iestyn Whitehouse, Assistant Professor in the Sloan Kettering Institute’s Molecular Biology programme, to hear the story behind the work.     Iestyn, can you[…]

The people behind the papers: Miguel Brun-Usan & Isaac Salazar-Ciudad

Posted by on January 4th, 2017

The tenth paper featured in this series comes from the first issue of Development for 2017, and uses computational modelling to investigate the importance of different cellular processes in spiral cleavage of the early embryo. We caught up with the paper’s first author Miguel Brun-Usan and Isaac Salazar-Ciudad, group leader at the University of Helsinki[…]

The people behind the papers: Andrew Schiffmacher & Lisa Taneyhill

Posted by on December 16th, 2016

The neural crest is a remarkable multipotent cell population that has become a model system for how epithelial cells become mesenchymal and migrate during development. In today’s post, we feature a paper from the recent issue of The Journal of Cell Biology that investigates the role that proteolysis of cell-cell adhesion receptors plays in this process. We caught[…]

The people behind the papers: Fernando Ferreira & Min Zhao

Posted by on December 14th, 2016

Today’s paper comes from the final issue of Development for 2016, and reveals a link between bioelectricity and reactive oxygen species during tail regeneration in Xenopus. We caught up with first author Fernando Ferreira and his advisor Min Zhao, Professor in Dermatology at UC Davis.     So Min, can you give me the brief history of your[…]

The people behind the papers: Amelia Joy Thompson, Sarah K Foster & Kristian Franze

Posted by on November 30th, 2016

Today’s paper comes from the latest issue of Nature Neuroscience, and shows that in addition to chemical cues, mechanical signals are vital for axon pathfinding during brain development. We caught up with PI Kristian Franze from the Department of Physiology, Development and Neuroscience at the University of Cambridge, and two of the paper’s four lead authors, Amelia[…]

The people behind the papers: James Nichols

Posted by on November 29th, 2016

Today’s paper comes from the latest issue of Development, and reveals a link between phenotypic variability, cell fate switching and epigenetic silencing in zebrafish. Lead author James T. Nichols, who carried out the work in Charles Kimmel’s lab in Euegene, Oregon and is now an Assistant Professor in UC Denver’s School of Dental Medicine, gave us the story behind[…]

The people behind the papers: Joseph Pickering & Matthew Towers

Posted by on October 25th, 2016

So far in this series, we’ve featured fly nuclear pores, lizard tails, squid eyes and mouse digits, and heard from researchers working in Germany, the US and Canada. Today, we switch model system and geographical location once again. The work was published recently in Development, and uses timed inhibition of sonic hedgehog signalling during chick[…]

The people behind the papers: Adam Johnston

Posted by on September 26th, 2016

Today we feature an upcoming paper in Cell Stem Cell that investigates the role of Schwann cell precursors in the multi-tissue regeneration of the adult mammalian distal digit tip.  We caught up with lead author Adam Johnston, who carried out the work in Freda Miller’s lab in the Hospital for Sick Children in Toronto, and has since started his[…]

The people behind the papers: Kristen Koenig & Jeffrey Gross

Posted by on September 2nd, 2016

Today’s paper is from the latest issue of Development and  introduces the squid Doryteuthis pealeii as a lophotrochozoan model for eye development. And the people are PI Jeffrey Gross, Director of the Louis J. Fox Center for Vision Restoration and Professor of Ophthalmology and Developmental Biology at the University of Pittsburgh, and lead author Kristen Koenig, who has[…]

The people behind the papers: Thomas Lozito

Posted by on August 22nd, 2016

Today’s paper is from the latest issue of Development and investigates the mechanisms of lizard tail regeneration, revealing distinct cell behaviours in the proximal versus distal regenerating tail. Today’s person is Thomas Lozito, Research Assistant Professor at the Center for Cellular & Molecular Engineering, University of Pittsburgh, and co-author with Rocky Tuan.     So Thomas, tell us a little bit[…]