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Spotlight on Rat: Translational Impact – a new DMM Special Collection

Posted by on October 18th, 2016

Disease Models & Mechanisms is pleased to announce the launch of a new Special Collection named Spotlight on Rat: Translational Impact. The rat is a key model for basic and preclinical studies of physiology, pharmacology, toxicology and neuroscience, underlining its importance in studies of human disease. There are many reasons for its suitability as a[…]

New phenotype screen examines causes of neonatal death

Posted by on October 4th, 2016

This post first appeared on Annotations, the DMDD blog ( Around a third of targeted gene knockouts in mice are embryonic-lethal. But not all deaths occur during gestation – a significant number of gene knockouts result in death at or shortly after the time of birth. Mice from these knockout lines provide a valuable animal[…]

Would peer review work better if reviewers talked to each other? An interview for Retraction Watch

Posted by on September 21st, 2016

As you may have seen, we at Development have recently announced a change to our peer review process, introducing a cross-referee commenting step. This should be in place within the next week or two, and we’re hoping it will help us to make better decisions on papers, and to make the revision process easier for[…]

Gene regulation, evolution and the exploitation of new habitats

Posted by on September 21st, 2016

Changes in body organ morphology have allowed animals to better exploit diverse habitats. As organ morphology is under genetic control, genetic modifications provide the basis for the wide range of morphologies. However, as our knowledge of the genetic basis of phenotypic diversification in evolution has focused mostly on quantitative traits, it is not clear how[…]

Introducing cross-referee commenting in peer review

Posted by on August 31st, 2016

This Editorial originally appeared in Development, Vol 143, Issue 17. Olivier Pourquié and Katherine Brown   At Development, we are always trying to improve our processes and service – for authors and readers. In April 2015, we made some changes to our peer review process, which aimed at encouraging a more constructive approach to peer review.[…]

Exciting news on neural stem cell niches: stunning research from Fiona Doetsch’s lab

Posted by on August 26th, 2016 Sense & Sensibility: niche signals regulate neural stem cells in an age-dependent manner paper feature by Thomas Schwarz-Romond Tissue specific stem cell niches provide lifelong support for adult stem cells. The cell-biological dissection of (adult neural) stem cell – niche interactions uncovered unexpected regulatory functions. These new results imply that stem cell niches actively[…]

The Zika Virus and Systematic Screens of Mouse Mutations

Posted by on July 14th, 2016

  This post was originally published on the DMDD blog.     The Zika virus has raised global awareness of birth defects more than at any time in the last 50 years [1]. A recent Nature Editorial explores the opportunities this presents to increase support for vaccination programmes, compulsory fortification of food staples and investment[…]

“People in this country have had enough of experts”

Posted by on July 2nd, 2016

I woke up this morning to a Facebook reminder of where I was 5 years ago. I was in Lille, France, on a 2 month sabbatical at Université Lille 1 from my PhD at the University of Cambridge, UK. It was supported by an EU collaborative grant to promote scientific interaction between member states.  […]

YEN 2016 review

Posted by on June 26th, 2016

My informal review of YEN this year is by necessity a bit rushed but, for what it is, here it is. Most reviews are very short and pithy/jealous and only exist for some of the talks where, for a combination of good and bad reasons, I paid attention (I have tried to make this review[…]

Hello from Aidan!

Posted by on June 14th, 2016

I’m happy to introduce myself as the Node’s new Community Manager, taking up the reins from Cat Vicente, who said goodbye recently, and left this unique site in great shape. I’ve come to the Node from the lab bench, recently as a postdoc with Nick Brown in Cambridge, and before that as PhD student with[…]