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The Node is a place to share news about and with the developmental biology community around the world. If this is your first time on the site, check out this introduction to the Node. You can also find out more about us, and sign up to contribute.
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Two recent workshops organised by The Company of Biologists
Posted by NickyLB on July 18th, 2014
As you probably know, The Company of Biologists (the not-for-profit publisher behind the Node and Development) funds a variety of meetings and conferences every year, and since 2010 that it also organises its own series of workshops. The workshops are generally interdisciplinary in nature, aiming to bring together researchers who do not necessarily meet otherwise. The […]
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The Node in Vienna (and at the European Evo-Devo meeting)
Posted by the Node on July 16th, 2014
The Node’s next stop is the capital of Austria- Vienna! Our visit will be in two parts: Cat, the Node community manager, will be giving a talk at the Vienna Biocenter Campus entitled ‘Joining the online conversation: how to use social media to communicate your science’. This will be an informal talk and Q&A which will […]
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EMBO celebrates 50 years
Posted by the Node on July 12th, 2014
The European Molecular Biology Organization (EMBO) is an organization that ‘promotes excellence in the life sciences’ in Europe and beyond. With more than 1500 members (leaders in their respective fields), it is a driving force in European science. Since its inception in 1964, EMBO has played an active role in promoting research in the life sciences, organising meetings […]
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We are 4 years old!
Posted by the Node on June 22nd, 2014
It is our birthday today! It is exactly 4 years since the Node was launched, and since then we have grown in users and readers every year! Thank you all for writing, commenting, rating and reading the Node! We hope you will join us in another year of great discussions, research, meetings, competitions, etc, etc, etc… […]
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(Developmental) Biology around the internet- June 2014
Posted by the Node on June 17th, 2014
Here is June’s round-up of some of the interesting content that we spotted around the internet: News & Research: - Fly developmental geneticist Walter Gehring sadly passed away this month. His influential research career included the discovery of the homeobox genes. - This last month saw new updates in the STAP case controversy- Haruko Obokata agreed […]
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Woods Hole images 2014 round 1- the winner
Posted by the Node on June 10th, 2014
Time to announce the winner of this year’s first round of Woods Hole images: the fluorescent image of the squid embryo! Many congratulations to Nathan Kenny (University of Oxford), Kathryn McClelland (Institute for Molecular Bioscience, University of Queensland), and Sophie Miller (University of Cambridge), who took this image at last year’s Woods Hole Embryology course. […]
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The PHD movie- support the sequel!
Posted by Cat Vicente on June 6th, 2014
If you are doing a PhD (or involved in research in any way), you probably take a lot of humour, procrastination and comfort from PHD comics. The comic strip ‘Piled Higher and Deeper’ has been portraying “life (or the lack thereof) in academia” since 1997, with a cast of characters ranging from a nameless graduate student […]
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(Developmental) Biology around the internet- May 2014
Posted by the Node on May 19th, 2014
Here is May’s round-up of some of the interesting content that we spotted around the internet: News & Research: - This month was a sad one for science, as two renowned scientists passed away: Robin Holliday and developmental biologist Julian Lewis. - The Royal Society announced their new fellows list, including several developmental biologists: Cliff Tabin, Liam […]
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Cosy Science talk- How do cells communicate to build tissues?
Posted by NickyLB on May 16th, 2014
Cosy Science is an informal pub gathering where scientists talk about their research over a pint of beer (or glass of wine!) with anyone who is interested in listening. It is mostly a monthly event, taking place at The Cittie of Yorke pub in London, and everyone is welcome! As you may know, The Company of Biologists […]
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Travelling Fellowships- deadline approaching!
Posted by NickyLB on April 16th, 2014
Do you need to learn a new technique? Are you planning a collaborative visit? Then The Company of Biologists and Development can help! We offer Travelling Fellowships of up to £2,500 to cover the costs of travel, accommodation, subsistence and visa fees. The next deadline for applications is the 30th of April! Find more information about how […]
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- talpid2: a mystery finally solved [IN THIS ISSUE]
- Starvation MESses up the egg [IN THIS ISSUE]
- A taste for something new [IN THIS ISSUE]
- Cell heterogeneity and multilineage priming in the kidney [IN THIS ISSUE]
- The POU-er of gene nomenclature [SPOTLIGHT]
- The dynamics of plant plasma membrane proteins: PINs and beyond [REVIEW]
- Retinoic acid controls body axis extension by directly repressing Fgf8 transcription [RESEARCH REPORTS]
- The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells [RESEARCH REPORTS]
- Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity [RESEARCH ARTICLES]
- Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium [RESEARCH ARTICLES]
- The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant talpid2 [RESEARCH ARTICLES]
- Starvation induces FoxO-dependent mitotic-to-endocycle switch pausing during Drosophila oogenesis [RESEARCH ARTICLES]
- A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex [RESEARCH ARTICLES]
- The origin and loss of periodic patterning in the turtle shell [RESEARCH ARTICLES]
- Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity [RESEARCH ARTICLES]
- Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis [RESEARCH ARTICLES]
- Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice [RESEARCH ARTICLES]
- Loss of focal adhesions in glia disrupts both glial and photoreceptor axon migration in the Drosophila visual system [RESEARCH ARTICLES]
- Islet is a key determinant of ascidian palp morphogenesis [RESEARCH ARTICLES]
- NF-kB controls axonal regeneration and degeneration through cell-specific balance of RelA and p50 in the adult CNS [Articles of interest in other COB journals]
- The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila [Articles of interest in other COB journals]
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- Editorial Board
- The basal position of nuclei is one pre-requisite for asymmetric cell divisions in the early mouse embryo
- The fat-like cadherin CDH-4 acts cell-non-autonomously in anterior–posterior neuroblast migration
- Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number
- Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton
- Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast
- Transcriptional regulation of Drosophila gonad formation
- Direct functional consequences of ZRS enhancer mutation combine with secondary long range SHH signalling effects to cause preaxial polydactyly
- Cdc42 is required in a genetically distinct subset of cardiac cells during Drosophila dorsal vessel closure
- Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1
- Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms
- Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation
- SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans
- GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development
- Migratory neural crest cell αN-catenin impacts chick trigeminal ganglia formation
- Specific pattern of cell cycle during limb fetal myogenesis
- Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development
- Nemo promotes Notch-mediated lateral inhibition downstream of proneural factors
- Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression
- Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos
- Hectd1 is required for development of the junctional zone of the placenta
- Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation
- miR-203 regulates progenitor cell proliferation during adult zebrafish retina regeneration
- Dynamics of F-actin prefigure the structure of butterfly wing scales
- Germ cells of the centipede Strigamia maritima are specified early in embryonic development
- The expansion of body coloration involves coordinated evolution in cis and trans within the pigmentation regulatory network of Drosophila prostipennis
- Emergence of tissue sensitivity to Hox protein levels underlies the evolution of an adaptive morphological trait
- Long bone development requires a threshold of Hox function
- Enhancer diversity and the control of a simple pattern of Drosophila CNS midline cell expression
- A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues
- Editorial Board
- Development of the lateral line canal system through a bone remodeling process in zebrafish
- NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling
- Protein kinase CK2 both promotes robust proliferation and inhibits the proliferative fate in the C. elegans germ line
- TAF4b promotes mouse primordial follicle assembly and oocyte survival
- Regulation of broad by the Notch pathway affects timing of follicle cell development
- Cited2 is required in trophoblasts for correct placental capillary patterning
- Polyspermy block in jellyfish eggs: Collaborative controls by Ca2+ and MAPK
- The role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless
- Phosphorylation of CDK2 at threonine 160 regulates meiotic pachytene and diplotene progression in mice
- Transcriptional co-regulation of evolutionarily conserved microRNA/cone opsin gene pairs: Implications for photoreceptor subtype specification
- Corrigendum to “prdm12b Specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements” [Dev. Biol. 390 (2014) 247–260]
- The proteins encoded by the drosophila planar polarity effector genes inturned, fuzzy and fritz interact physically and can re-pattern the accumulation of “upstream” planar cell polarity proteins.
- Short neuropeptide F (sNPF) is a stage-specific suppressor for juvenile Hormone biosynthesis by corpora allata, and a critical factor for the initiation of insect metamorphosis
- The contrasting roles of primary cilia and cytonemes in Hh signaling
- Corrigendum to “Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRII asynaptic accumulation and bouton number” [Dev. Biol. 392 (2014) 153–167]
- Formation of cholinergic synapse-like specializations at developing murine muscle spindles
- Ephrin-mediated restriction of ERK1/2 activity delimits the number of pigment cells in the Ciona CNS
- Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice
- Specification of the mouse cardiac conduction system in the absence of Endothelin signaling
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- Wnt some lose some: transcriptional governance of stem cells by Wnt/{beta}-catenin signaling [Reviews]
- Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling [Reviews]
- Two waves of de novo methylation during mouse germ cell development [Research Communications]
- TRF2, but not TBP, mediates the transcription of ribosomal protein genes [Research Communications]
- Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1 [Research Communications]
- The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages [Research Papers]
- Lineage of origin in rhabdomyosarcoma informs pharmacological response [Research Papers]
- Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions [Research Papers]
- A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication [Research Papers]
- MicL, a new {sigma}E-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein [Research Papers]
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- Encoding of Temporal Signals by the TGF-β Pathway and Implications for Embryonic Patterning
- Gap Junction Proteins in the Blood-Brain Barrier Control Nutrient-Dependent Reactivation of Neural Stem Cells
- Yap Tunes Airway Epithelial Size and Architecture by Regulating the Identity, Maintenance, and Self-Renewal of Stem Cells
- The Hippo Pathway Effector Yap Controls Patterning and Differentiation of Airway Epithelial Progenitors
- Spatial Regionalization and Heterochrony in the Formation of Adult Pallial Neural Stem Cells
- SAS-6 Assembly Templated by the Lumen of Cartwheel-less Centrioles Precedes Centriole Duplication
- Mother Centrioles Do a Cartwheel to Produce Just One Daughter
- Walter Jakob Gehring (1939–2014)
- A Long Noncoding Way to Alternative Splicing in Plant Development
- Dll4 and PDGF-BB Convert Committed Skeletal Myoblasts to Pericytes without Erasing Their Myogenic Memory
- A Whiter Shade of Gray: HIF and Coordination of Angiogenesis with Postnatal Myelination
- Sizing Up Lung Stem Cells
- A Time and Place for Understanding Neural Stem Cell Specification
- Global Programmed Switch in Neural Daughter Cell Proliferation Mode Triggered by a Temporal Gene Cascade
- Long Noncoding RNA Modulates Alternative Splicing Regulators in
- EGFR Modulates DNA Synthesis and Repair through Tyr Phosphorylation of Histone H4
- Roles for Pbp1 and Caloric Restriction in Genome and Lifespan Maintenance via Suppression of RNA-DNA Hybrids
- High-Resolution Temporal Analysis Reveals a Functional Timeline for the Molecular Regulation of Cytokinesis
