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Sweetening with a pinch of salt: maximized Cas9 efficiency in zebrafish

Posted by on June 14th, 2016

  Alexa Burger, Mosimann lab, Institute of Molecular Life Sciences, University of Zürich, Switzerland. When I first heard about the “new” genome editing method in early 2013 called CRISPR-Cas9, I thought: “Never ever again will I work with targeted nucleases!” Now it’s mid-2016, we published our approaches to maximize Cas9 effectiveness in zebrafish with Development[…]

Call for Papers: a Special Collection on Neurodegenerative Diseases

Posted by on May 31st, 2016

Disease Models & Mechanisms invites you to submit original research for consideration for an upcoming Special Collection ‘Neurodegeneration: From Models to Mechanisms to Therapies‘. This ongoing collection will focus on mechanistic insights into neurodegenerative diseases using model systems, with an emphasis on key translational advances made in recent years. This collection will be launched with[…]

2 technical and 1 post-doctoral posts in cell biology, molecular endocrinology and skeletal biology, Imperial College London

Posted by on May 24th, 2016

Professors Graham Williams and Duncan Bassett have 3 full-time posts (5 years each) available. One technical post in skeletal biology is funded by the Horizon 2020 grant: Resetting the THYRoid axis for prevention of AGE-related diseases and co-morbidities. One post-doc and one technician post in molecular and cellular biology are funded by the Wellcome Trust:[…]

Reflecting on the student & postdoc events at the BSCB/BSDB Spring Meeting

Posted by on May 23rd, 2016

Last year, the BSDB carried out a student and postdoc survey (see here), and the results clearly highlighted the need for more dedicated program items for young researchers on BSDB conferences. In response, the BSDB student rep Alex Ashcroft, the BSCB postdoc rep Alexis Barr, and the BSDB postdoc rep  Michelle Ware took initiative and[…]

A mouse embryo atlas using HREM data

Posted by on May 23rd, 2016

For the first time, a reference mouse embryo atlas has been created using HREM image data. For other embryo imaging methods such as micro-CT, a reference embryo atlas has previously been shown to be the basis of automated phenotyping (Wong et al, 2014). This new work (a collaboration between the DMDD programme and the Mouse[…]

Recovering from an earthquake: update from IMEG

Posted by on May 13th, 2016

I recently learned that the recent earthquakes in Kumamoto, Japan, severely affected the Institute of Molecular Embryology and Genetics (IMEG) – home to a large community of developmental biologists. Fortunately, none of the institute’s staff were seriously injured, but there was significant damage to the building and the research infrastructure and it will take a[…]

Big data: challenges and opportunities

Posted by on May 11th, 2016

“With great power comes great responsibility” In recent years, next-generation-sequencing approaches have churned out a huge amount of ‘big data’ – a wealth of digital information that could one day have a powerful impact on biomedical research. Recognising the potential of big data to improve our understanding of human health and disease, the NIH partnered[…]

New Node banners!

Posted by on May 6th, 2016

As you may have noticed, we have a series of new Node banners (alongside some of our old favourites). As there isn’t really space to give credit to the authors on the banner itself, we thought we would write this short post to give credit where credit is due! Below is the list of the[…]

Goodbye from Cat!

Posted by on May 6th, 2016

Today is my last day on the Node, so this is my chance to say goodbye!  It has been 3 very busy years on the Node, but I have really enjoyed myself! When I first started on the Node I was fresh out of my PhD (actually, I was still writing my thesis) and my[…]

YEN 2016 – register now!

Posted by on May 4th, 2016

Young Embryologists’ Network 2016 As a neglectful member of this parish over the last few months/years (insert standard academic administration/teaching workload complaints here), I have the great pleasure to come out of my slumber to drum up interest in one of the best things about being (a developmental biologist) in London: If you have[…]