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Overly Honest Methods
Posted by Eva Amsen on January 8th, 2013
Why did you incubate that sample for 16 hours? Because you wanted to go home for the day - but that much detail is not in your paper! Last night, a few scientists on Twitter started sharing their “overly honest methods”, and today the #overlyhonestmethods hashtag exploded with lots of funny and true stories about scientific experimentation. There are thousands of tweets, still coming in, so I can’t show you all of them, but here is a selection of some of my favourites:
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- Centrosomes and cell fate: a Notch ahead [IN THIS ISSUE]
- Fishing out maternal and zygotic transcriptomes [IN THIS ISSUE]
- Imaging the neurogenic niche [IN THIS ISSUE]
- A new vein of lumen formation [IN THIS ISSUE]
- Specifying hepatopancreas progenitors [IN THIS ISSUE]
- A lnc between coding and non-coding RNAs [IN THIS ISSUE]
- The San Francisco Declaration on Research Assessment [EDITORIAL]
- Lineage-dependent circuit assembly in the neocortex [REVIEW]
- Decoupling of amniote gastrulation and streak formation reveals a morphogenetic unity in vertebrate mesoderm induction [RESEARCH REPORTS]
- Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development [RESEARCH REPORTS]
- Identification of the zebrafish maternal and paternal transcriptomes [RESEARCH ARTICLES]
- Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma [RESEARCH ARTICLES]
- Distinct functional domains of the Abelson tyrosine kinase control axon guidance responses to Netrin and Slit to regulate the assembly of neural circuits [RESEARCH ARTICLES]
- Laminin {beta}1a controls distinct steps during the establishment of digestive organ laterality [RESEARCH ARTICLES]
- Sequential activation of ETS proteins provides a sustained transcriptional response to EGFR signaling [RESEARCH ARTICLES]
- miR-34b regulates multiciliogenesis during organ formation in zebrafish [RESEARCH ARTICLES]
- barx1 represses joints and promotes cartilage in the craniofacial skeleton [RESEARCH ARTICLES]
- The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment [RESEARCH ARTICLES]
- ArhGEF18 regulates RhoA-Rock2 signaling to maintain neuro-epithelial apico-basal polarity and proliferation [RESEARCH ARTICLES]
- The Drosophila GOLPH3 homolog regulates the biosynthesis of heparan sulfate proteoglycans by modulating the retrograde trafficking of exostosins [RESEARCH ARTICLES]
- The Maf factor Traffic jam both enables and inhibits collective cell migration in Drosophila oogenesis [RESEARCH ARTICLES]
- Programmed reduction of ABC transporter activity in sea urchin germline progenitors [CORRIGENDUM]
- A high-throughput template for optimizing Drosophila organ culture with response-surface methods [CORRIGENDUM]
- Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replaceing Neurod1 with Atoh7 [CORRIGENDUM]
- Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-{beta}/Smad signalling [ARTICLES OF INTEREST IN OTHER COB JOURNALS]
- Six1 regulates proliferation of Pax7-positive muscle progenitors in zebrafish [ARTICLES OF INTEREST IN OTHER COB JOURNALS]
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- Cover 2, Editorial Board, barcode
- Waves of differentiation in the fly visual system
- A temporal mechanism that produces neuronal diversity in the Drosophila visual center
- Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate
- The cytoskeletal protein Zyxin inhibits Shh signaling during the CNS patterning in Xenopus laevis through interaction with the transcription factor Gli1
- A distant, cis-acting enhancer drives induction of Arf by Tgfβ in the developing eye
- The G alpha subunit Gα8 inhibits proliferation, promotes adhesion and regulates cell differentiation
- Zebrafish Zic2a and Zic2b regulate neural crest and craniofacial development
- Differential stage-dependent regulation of prostatic epithelial morphogenesis by Hedgehog signaling
- ESET histone methyltransferase is essential to hypertrophic differentiation of growth plate chondrocytes and formation of epiphyseal plates
- Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth
- Evolution of the insect terminal patterning system—Insights from the milkweed bug, Oncopeltus fasciatus
- Cover 2, Editorial Board, barcode
- Midbrain dopaminergic neurons: A review of the molecular circuitry that regulates their development
- The union of somatic gonad precursors and primordial germ cells during Caenorhabditis elegans embryogenesis
- Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary
- dBre1/dSet1-dependent pathway for histone H3K4 trimethylation has essential roles in controlling germline stem cell maintenance and germ cell differentiation in the Drosophila ovary
- A multipotent transit-amplifying neuroblast lineage in the central brain gives rise to optic lobe glial cells in Drosophila
- Myf5 expression during fetal myogenesis defines the developmental progenitors of adult satellite cells
- Differential BMP signaling controls formation and differentiation of multipotent preplacodal ectoderm progenitors from human embryonic stem cells
- Mouse limbs expressing only the Gli3 repressor resemble those of Sonic hedgehog mutants
- The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling
- PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively
- Primordial germ cells in an oligochaete annelid are specified according to the birth rank order in the mesodermal teloblast lineage
- Mathematical model of a gene regulatory network reconciles effects of genetic perturbations on hematopoietic stem cell emergence
- Cover 2, Editorial Board, barcode
- A unified model for left–right asymmetry? Comparison and synthesis of molecular models of embryonic laterality
- The Xenopus Tgfbi is required for embryogenesis through regulation of canonical Wnt signalling
- TAF13 interacts with PRC2 members and is essential for Arabidopsis seed development
- Wntless is required for peripheral lung differentiation and pulmonary vascular development
- Coactosin accelerates cell dynamism by promoting actin polymerization
- dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth
- dusky-like is required to maintain the integrity and planar cell polarity of hairs during the development of the Drosophila wing
- Sox10 and Itgb1 interaction in enteric neural crest cell migration
- An organizing activity is required for head patterning and cell fate specification in the polychaete annelid Capitella teleta: New insights into cell–cell signaling in Lophotrochozoa
- Dvr1 Transfers Left-Right Asymmetric Signals from Kupffer's Vesicle to Lateral Plate Mesoderm in Zebrafish
- Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis
- Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish
- Cover 2, Editorial Board, barcode
- Developmental Biology course in Chile open to Latin American and International applicants
- Ric-8A, a guanine nucleotide exchange factor for heterotrimeric G proteins, is critical for cranial neural crest cell migration
- Smad signaling pathways regulate pancreatic endocrine development
- Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation
- Sulf1 modulates BMP signaling and is required for somite morphogenesis and development of the horizontal myoseptum
- APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression
- Activated Cdc42 kinase regulates Dock localization in male germ cells during Drosophila spermatogenesis
- Following the ‘tracks’: Tramtrack69 regulates epithelial tube expansion in the Drosophila ovary through Paxillin, Dynamin, and the homeobox protein Mirror
- The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands
- Transcriptional regulation of the peripheral nervous system in Ciona intestinalis
- Duplications of hox gene clusters and the emergence of vertebrates
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- State-dependent signaling by Cav1.2 regulates hair follicle stem cell function [Research Communications]
- Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation [Research Papers]
- Bicaudal-D uses a parallel, homodimeric coiled coil with heterotypic registry to coordinate recruitment of cargos to dynein [Research Papers]
- Tissue-specific splicing of a ubiquitously expressed transcription factor is essential for muscle differentiation [Research Papers]
- linc-HOXA1 is a noncoding RNA that represses Hoxa1 transcription in cis [Research Papers]
- Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone [Research Papers]
- Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation [Research Papers]
- The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy [Research Papers]
- Dynamic binding of RBPJ is determined by Notch signaling status [Errata]
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- Protein Aggregation Behavior Regulates Cyclin Transcript Localization and Cell-Cycle Control
- Discovering Regulators of Centriole Biogenesis through siRNA-Based Functional Genomics in Human Cells
- Oct4 Cell-Autonomously Promotes Primitive Endoderm Development in the Mouse Blastocyst
- Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation
- Vesicle Transport and Photoreceptor Death: Fishing for Molecular Links
- My Brain Told Me to Do It
- The Art of Choreographing Asymmetric Cell Division
- Switching Axial Progenitors from Producing Trunk to Tail Tissues in Vertebrate Embryos
- TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis
- Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration
- In Vivo Analysis Reveals a Highly Stereotypic Morphogenetic Pathway of Vascular Anastomosis
- Focal Defects in Single-Celled Tubes Mutant for Cerebral Cavernous Malformation 3, GCKIII, or NSF2
- The Yeast Alix Homolog Bro1 Functions as a Ubiquitin Receptor for Protein Sorting into Multivesicular Endosomes
- PTEN Controls Junction Lengthening and Stability during Cell Rearrangement in Epithelial Tissue
