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PhD position: Chromosome Dynamics During Spermatogenesis in Drosophila, University of Zurich, Switzerland

Posted by on April 19th, 2018

We seek candidates interested in completing a PhD thesis within the framework of a research project (46 months) funded by the Swiss National Science Foundation (SNF). Chromosome reorganization during spermatogenesis is dramatic. Beyond meiosis, it includes chromosome compaction into an elongated sperm nucleus which is accompanied by an almost complete exchange of histones with sperm[…]

PhD project on membrane trafficking dynamics during epithelial polarization

Posted by on April 3rd, 2018

The newly established Collaborative Research Center 1348 “Dynamic Cellular Interfaces: Formation and Function” at the University of Münster, Germany, invites applications for a   PhD Position (salary level 13 TV-L, 65%) in the area of Membrane trafficking dynamics during epithelial polarization This fixed-term position is available from the earliest possible date for three years. The[…]

When the obvious fails, look at the unexpected: interneuron individual behavior affects the population migration.

Posted by on March 19th, 2018

The story behind our paper: Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis. Carla G. Silva, Elise Peyre, Mohit H. Adhikari, Sylvia Tielens, Sebastian Tanco, Petra Van Damme, Lorenza Magno, Nathalie Krusy, Gulistan Agirman, Maria M. Magiera, Nicoletta Kessaris, Brigitte Malgrange, Annie Andrieux, Carsten Janke, Laurent Nguyen   The research behind this article is a[…]

The people behind the papers – You Wu & Mineko Kengaku

Posted by on March 12th, 2018

Neuronal migration is critical for mammalian brain development. In many migrating neurons, the nucleus translocates from the trailing to the leading edge of the cell in a manner dependent on the actin and microtubule cytoskeletons, but how these cytoskeletons interact and their relative contribution to the forces that move the nucleus has remained unclear. This[…]

Postdoctoral Fellow in Neurodevelopment

Posted by on January 18th, 2018

Applications are invited from highly motivated individuals who are interested in fundamental mechanisms of neuronal migration and axon guidance. The main focus of our research is to understand the molecular and cellular mechanisms underlying the development of neural circuits using the embryonic spinal cord as a model system (http://www.ucmm.umu.se/english/research/sara-wilson/). The fellowship is funded for two[…]

This year for Christmas, gift yourself with an amazing experience. Apply today for the 2018 CSHL Cell and Developmental Biology of Xenopus course.

Posted by on December 18th, 2017

The end of the year is quickly approaching, and if you are anything like me you are scrambling to try to get as much work done as possible before your holiday break. But while this frequently entails getting papers submitted, committee meetings completed, and experiments wrapped up, I also take the opportunity to reflect on[…]

Synthetic Materials for Human Organoid Generation and Wound Healing (The Journey)

Posted by on November 20th, 2017

Looking back on the journey of: Ricardo Cruz-Acuña and Miguel Quirós et al. Nature Cell Biology (2017) The Start  On August 2013, I took my first one-way trip departing from Puerto Rico. Although I have always been passionate about travelling to as many places (the cheapest way) possible, embracing the PhD-journey in a new city[…]

Regulation of cell polarity by EGF signaling controls both organ architecture and cell fate

Posted by on October 23rd, 2017

Scientists at DanStem discovered that cells’ sense of direction (cell polarity) determines their destiny. By discovering the signals that control cell polarity in the developing organism, scientists can now mimic it in a test tube and control the fate of human stem cells. The results accelerate the efforts to generate specialized cells, e.g. insulin-producing beta[…]

Two fully-funded PhD positions in Wnt trafficking at the LSI in Exeter

Posted by on October 9th, 2017

The process of subdividing a tissue into functional units represents a classic problem in pattern formation. Signalling proteins – so-called morphogens – orchestrate this process. The traditional view is that morphogens are released from local source and slowly diffuse through a neighbouring tissue to build up a gradient. As Wnt signals act as a key[…]

Layered patterning systems in hair development

Posted by on September 28th, 2017

The story behind our recent paper  ‘Hierarchical patterning modes orchestrate hair follicle morphogenesis‘ , finding that distinct patterning mechanisms can co-exist during embryonic organ formation.   From the spots of a leopard and stripes on a zebra to the pigmentation of sea shells and arrangement of sand dunes in a desert, repeating patterns are present[…]