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Development Special Issue: Chromatin and Epigenetics

Posted by on March 14th, 2019

Development invites you to submit your latest research for our upcoming special issue: Chromatin and Epigenetics. This issue will be coordinated by several of our Academic Editors who are experts in this field: Benoit Bruneau, Haruhiko Koseki, Susan Strome and Maria Elena Torres-Padilla. Recent years have seen huge advances in our understanding of how DNA and histone modifications, chromatin[…]

Reflections on the ‘Evo-chromo’ Workshop (November 2018)

Posted by on March 5th, 2019

Alexander Blackwell and James Gahan   At the beginning of November 2018, thirty researchers congregated at Wiston House to attend a workshop titled ‘Evo-chromo: towards an integrative approach of chromatin dynamics across eukaryotes’. The workshop was organised by Frederic Berger (Gregor Mendel Institute) and Ines Anna Drinnenberg (Institut Curie), and was the 27th workshop hosted[…]

Postdoctoral position in Chromatin and Epigenetics in Drosophila Development

Posted by on December 19th, 2018

Stockholm University, Sweden, invites applications for one postdoctoral position in the laboratory of Professor Mattias Mannervik at the Department of Molecular Biosciences, The Wenner-Gren Institute (http://www.su.se/mbw). The position is scheduled to start as soon as possible. Transcriptional coregulators are proteins that facilitate communication between transcription factors and the basal transcription apparatus, in part by affecting[…]

Of Arms and Legs: Shedding light onto developmental gene regulation

Posted by on November 19th, 2018

Written and illustrated by: Bjørt K. Kragesteen, Malte Spielmann, and Guillaume Andrey.   In early development, the forelimb and hindlimb buds of tetrapods are morphologically uniform. However, as limb development proceeds, each individual tissue attains a characteristic morphology that ultimately defines the identity of a forelimb (arm) or a hindlimb (leg). How do undifferentiated limbs[…]

Chromatin-based regulation of development: Funded early-career places available

Posted by on November 19th, 2018

In April 2019, The Company of Biologists Workshop ‘Chromatin-based regulation of development‘ will be held in Wiston House, a 16th century Grade I listed building located at the foot of the South Downs in West Sussex. Organised by Benoit Bruneau and Joanna Wysocka, the workshop will foster discussion of what mechanisms related to chromatin biology are informing[…]

The people behind the papers – Anjali Rao & Carole LaBonne

Posted by on August 9th, 2018

The neural crest is a progenitor population with the capacity to contribute to all vertebrate germ layers. The transcription factor and signalling pathway activity underlying this remarkable pluripotency have been well studied, but the role of the epigenetic state is less well understood. A new paper in Development examines the role of histone acetylation in regulating[…]

Evo-chromo: towards an integrative approach of chromatin dynamics across eukaryotes

Posted by on July 18th, 2018

***Deadline to apply for funded ECR places is July 20!***   In November, the Company of Biologists is hosting the latest in its series of Workshops. ‘Evo-chromo’ aims to integrate skills and interests of the fields of chromatin biology and evolutionary biology – if you are an early career researcher and this all sounds appealing[…]

Postdoctoral Position in Pluripotency, Signaling and Epigenetics, Washington University School of Medicine

Posted by on July 13th, 2018

A postdoctoral position is available in the lab of Thorold Theunissen at Washington University School of Medicine in St. Louis, Missouri, USA (theunissenlab.wustl.edu). Our research program is dedicated to exploring the molecular regulation of pluripotent stem cells and their applications in regenerative medicine. We have developed methods for inducing and maintaining human embryonic stem cells[…]

In vivo profiling of chromatin accessibility with CATaDa

Posted by on March 13th, 2018

The following post is an introduction into the technnique described in our recent paper: Aughey, G.N., et al., CATaDa reveals global remodelling of chromatin accessibility during stem cell differentiation in vivo. Elife, 2018. 7.   Attempting to understand the biology of a complex organ, like the brain, comes with an array of technical challenges. Those[…]

Two birds with one stone: CTCF control of dynamic gene expression during heart development.

Posted by on October 9th, 2017

CTCF binds to chromatin and is thought of as an architectural protein in the genome. If the genome were a text, CTCF would act like the punctuation marks, so that words are grouped together becoming meaningful sentences. When I started my PhD, the Manzanares lab had been fruitfully collaborating with that of Jose Luis Gómez-Skarmeta at[…]