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Displaying posts with the tag: epiblast [Clear Filter]

An interview with Jenny Nichols

Posted by on August 17th, 2017

This interview by Aidan Maartens originally appeared in Development, Volume 143, Issue 16. Jennifer Nichols is a Principal Investigator at the Cambridge Stem Cell Institute and Department of Physiology, Development and Neuroscience at the University of Cambridge, UK. Her lab works on lineage segregation and the establishment of pluripotency in the mammalian embryo. In 2017 she was[…]

When real life becomes equations: Control of Epiblast and Primitive Endoderm specification during mouse preimplantation development.

Posted by on September 23rd, 2014

During mouse preimplantation development, the zygote divides and forms three distinct lineages: one embryonic called the Epiblast (Epi) and two extraembryonic called trophectoderm (TE) and Primitive Endoderm (PrE). The first cell fate decision occurs at the morula stage (from 16-cell to 32-cell) between TE and the Inner Cell Mass (ICM) and the second cell fate[…]

Gastrulation: Local actions, global movements and self-organisation

Posted by on June 6th, 2014

Cells move in (still) mysterious ways to achieve morphogenesis. Prominently, cells of an early vertebrate embryo (blastula, a mass of undifferentiated cells) move extensively during gastrulation to generate the three basic layers of the organism: ectoderm at the surface, endoderm presaging the digestive tube, and the mesoderm in between. At the end of the process,[…]