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The forces that shape us: Mechanics of mammalian neural tube morphogenesis

Posted by on July 7th, 2017

Introduction to the biomechanics of neurulation Those of us who go to the gym are accustomed to thinking of mechanical forces shaping our bodies. Physiological (e.g. determination of bone mass and architecture), pathological (e.g. aneurysm rupture) and even socio-cultural (e.g. lip plates of the Mursi tribe) examples come to mind. The form of most of[…]

Dynamic new roles for local RNA regulation in neural stem cells of the developing brain

Posted by on December 22nd, 2016

Debby Silver and Louis-Jan Pilaz Comment on Pilaz, at al. Current Biology. 26(24): 3383-3392   Neurons and glia of the developing brain are produced from an elegant cell cell type called radial glia. These stem cells are fascinating not only because of their inherent multipotent nature, but also because of their unique bipolar morphology. Radial glia are[…]

From our sister journals- January 2016

Posted by on January 26th, 2016

Here is some developmental biology-related content from other journals published by The Company of Biologists.     Characterisation of Slc9a6 knockout heterozygous female mice Mutations in SLC9A6 are responsible for X-linked Christianson syndrome, a neurodevelopmental disease. Sikora and colleagues demonstrate that female mice heterozygous for a Slc9a6 knockout present mosaic neuropathology and similar but milder behavioural traits to those of affected[…]

Stem cells…now showing in 3D

Posted by on January 22nd, 2015

    Growing organs in vitro is one of the ultimate dreams of any stem cell biologist. As such, it seems obvious that some of these organs will need to be grown in 3D. This is why stem cell 3D culture systems are very fashionable among scientists. They are increasingly successful and a fair amount[…]

PhD studentship in evolutionary developmental genetics of neural progenitor proliferation

Posted by on November 23rd, 2014

A fully funded studentship (fees and RCUK-level stipend) open to EU students is available under the supervision of Dr Thomas Butts in the School of Biological and Chemical Sciences at Queen Mary, University of London. The studentship is to study the evolution of neural development within vertebrates, particularly in relation to the control of neurogenesis. Within this broad area of interest[…]

Use it or Lose it: Insights on neuronal connections in the vertebrate retina

Posted by on May 18th, 2014

This is the final post from our developmental neurobiology seminar this semester. Two students wrote about our discussion of the importance of neuronal activity during synaptogenesis and their professor combined and edited the pieces. As usual, we focused  on development in the vertebrate retina. Hope you’ve enjoyed our contributions, we’ve enjoyed sharing our new-found understanding.[…]

A fruitful visit from INB to INA

Posted by on December 15th, 2013

My name is Daniel Ríos and I am a grad student at the ‘Instituto de Neurobiología (INB)’ from the National Autonomous University of Mexico. However, during this past October I was part of the ‘Instituto de Neurociencias de Alicante (INA)’, from the Miguel Hernandez University, in Spain. Ok, I was there just for a short time working[…]

PhD-student Position in Thalamus Development / Tissue Engineering in Zebrafish

Posted by on September 21st, 2011

We are looking for a highly motivated PhD student to study development and regeneration of the thalamus in zebrafish. Stroke is a prevalent and devastating disorder, and no treatment is currently available to restore lost neuronal function after stroke. In 10% of all stroke patients, a remote damage of the thalamus has been documented. We[…]