1 PhD Position : Characterization of Hedgehog morphogens in vitro and in vivo

1 PhD Position : Characterization of Hedgehog morphogens in vitro and in vivo

Hedgehog (Hh) morphogens play important roles in development and cancer, but their mode of extracellular transport to target cells is only poorly understood. Thus, we aim at the characterization of various unusual posttranslational regulatory mechanisms in Hh biology, such as Hh multimerization on the surface of secreting cells via structural and biochemical analysis of Hh clusters, and the unusual mode of Hh transport and gradient formation.

We use a wide range of biochemical methods, such as recombinant protein production and chromatographic/functional characterization of proteins and Heparan sulfate-proteoglycans (HSPGs), determination of Shh/HSPG binding and in vivo testing of any obtained models of protein association and transport (In Drosophila melanogaster).

We invite applications from highly qualified and motivated students of any nationality. The applicant will hold a Masters degree (Biology, Chemistry, Biotechnology, Pharmacy or Biochemistry) and has gained first biochemical research experience. Experience in Drosophila experimentation is highly welcome, but not required. The successful applicant will find strong support within the excellent interdisciplinary environment of the SFB1348 of the University of Muenster.

Additional information can be found here:

https://www.medizin.uni-muenster.de/physiolchem.html

and here:

http://sfb1348.uni-muenster.de/

Starting date: at or around 1.1.2019 at the applicants convenience.

Timeframe: 3 years

Payment: 1 PhD contract (TV-L E13 65%, approximately 2300€ before taxes)

Interested? Please apply electronically to Prof. Dr. Kay Grobe, kgrobe@uni-muenster.de

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