Centromere Biology and Function in Developing Germ Cells

Centromeres are chromosomal loci that direct chromosome segregation at cell division. The successful candidate will contribute to a major aim of the Science Foundation Ireland Frontiers for the Future Award to investigate molecular mechanisms of centromere assembly, maintenance, and function in germ cells and in early animal development. This project will involve the manipulation of Drosophila and/or mammalian sperm and testes. A major aim is to discover molecular mechanisms that maintain centromeric chromatin during sperm differentiation. Experimental techniques to be performed will include: molecular biology and cloning, protein purification and biochemistry, the generation of transgenic animals, cell culture and high- and super-resolution fluorescence microscopy on fixed and live cells and tissues.017-23 Job Advert