Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints.

The preprints this month are hosted on bioRxiv – use these links below to get to the section you want:

Developmental biology

• Patterning & signalling
• Morphogenesis & mechanics
• Genes & genomes
• Stem cells, regeneration & disease modelling
• Plant development
• Evo-devo

Cell Biology

Modelling

Tools & Resources

Research practice and education

Developmental biology

| Patterning & signalling

Rbm8a deficiency causes hematopoietic defects by modulating Wnt/PCP signalingv

Agnese Kocere, Elena Chiavacci, Charlotte Soneson, Harrison H. Wells, Kevin Manuel Méndez-Acevedo, Jacalyn S. MacGowan, Seth T. Jacobson, Max S. Hiltabidle, Azhwar Raghunath, Jordan A. Shavit, Daniela Panáková, Margot L. K. Williams, Mark D. Robinson, Christian Mosimann, Alexa Burger

Hedgehog signaling is required for the maintenance of mesenchymal nephron progenitors

Eunah Chung, Patrick Deacon, Yueh-Chiang Hu, Hee-Woong Lim, Joo-Seop Park

Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism

Kim Moorwood, Florentia M. Smith, Alastair S. Garfield, Michael Cowley, Lowenna J. Holt, Roger J. Daly, Andrew Ward

Genetic interference with HvNotch provides new insights into the role of the Notch-signalling pathway for developmental pattern formation in Hydra

Qin Pan, Moritz Mercker, Alexander Klimovich, Jörg Wittlieb, Anna Marciniak-Czochra, Angelika Böttger

FGF2 promotes the expansion of parietal mesothelial progenitor pools and inhibits BMP4-mediated smooth muscle cell differentiation

Youngmin Hwang, Yuko Shimamura, Junichi Tanaka, Akihiro Miura, Anri Sawada, Hemanta Sarmah, Dai Shimizu, Yuri Kondo, Zurab Ninish, Kazuhiko Yamada, Munemasa Mori

TBX3 is essential to establish the posterior boundary of anterior genes and up-regulate posterior genes with HAND2 during onset of limb bud development

Geoffrey Soussi, Ausra Girdziusaite, Shalu Jhanwar, Victorio Palacio, Rushikesh Sheth, Rolf Zeller, Aimée Zuniga

Notch controls early temporal factor expression to control timing of Mushroom body neuroblast apoptosis

Kendall R. Branham, Chhavi Sood, Susan E. Doyle, Matt C. Pahl, Sarah E. Siegrist

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial compartment of the developing cochlea

Sandra de Haan, Agustin A. Corbat, Christopher R. Cederroth, Lisa G. Autrum, Simona Hankeova, Elizabeth C. Driver, Barbara Canlon, Matthew W. Kelley, Emma R. Andersson

Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst

Claire S. Simon, Afshan McCarthy, Laura Woods, Desislava Staneva, Qiulin Huang, Madeleine Linneberg-Agerholm, Alex Faulkner, Athanasios Papathanasiou, Kay Elder, Phil Snell, Leila Christie, Patricia Garcia, Valerie Shaikly, Mohamed Taranissi, Meenakshi Choudhary, Mary Herbert, Joshua M. Brickman, Kathy K. Niakan

A TBX5-dependent compartment boundary patterns the cardiac interventricular septum

Irfan S. Kathiriya, Martin H. Dominguez, Kavitha S. Rao, Jonathon M. Muncie-Vasic, W. Patrick Devine, Kevin M. Hu, Swetansu K. Hota, Bayardo I. Garay, Diego Quintero, Piyush Goyal, Megan N. Matthews, Reuben Thomas, Tatyana Sukonnik, Dario Miguel-Perez, Sarah Winchester, Emily F. Brower, André Forjaz, Pei-Hsun Wu, Denis Wirtz, Ashley L. Kiemen, Benoit G. Bruneau

Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis

Alyssa A Emig, Megan Hansen, Sandra Grimm, Cristian Coarfa, Nathan D Lord, Margot Kossmann Williams

Identifying the molecular basis for functional divergence of duplicated SOX factors controlling endoderm formation and left-right patterning in zebrafish

Simaran Johal, Randa Elsayed, Kristen A. Panfilio, Andrew C. Nelson

Hemilineage-specific expression of the RHG genes Grim and Reaper sculpt neural network composition during Drosophila neurogenesis

Connor J Sproston, Julia E Rak, Shu Kondo, Darren W Williams

Heterogeneity of Sonic Hedgehog response dynamics and fate specification in single neural progenitors

Fengzhu Xiong, Andrea R Tentner, Sandy Nandagopal, Tom W Hiscock, Peng Huang, Sean Megason

The deubiquitylating enzyme Fat Facets promotes Fat signalling and restricts tissue growth

Lauren E Dawson, Alexander D Fulford, Aashika Sekar, Paulo S Ribeiro

NOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT

Vinay Shukla, Ayelen Moreno-Irusta, Kaela M. Varberg, Marija Kuna, Khursheed Iqbal, Anna M. Galligos, John D. Aplin, Ruhul H. Choudhury, Hiroaki Okae, Takahiro Arima, Michael J. Soares

Lineage-specific intersection of endothelin and GDNF signaling in enteric nervous system development

Denise M. Poltavski, Alexander T. Cunha, Jaime Tan, Henry M. Sucov, Takako Makita

Duplication of the anteroposterior body axis in postembryos of the Eratigena atrica spider

Teresa Napiórkowska, Julita Templin, Paweł Napiórkowski

Diverse Fgfr1 signaling pathways and endocytic trafficking regulate early mesoderm development

James F. Clark, Philippe Soriano

Skeletal progenitor LRP1 deficiency causes severe and persistent skeletal defects with WNT/planar cell polarity dysregulation

Mohammad Alhashmi, Abdulrahman ME Gremida, Santosh K Maharana, Marco Antonaci, Amy Kerr, Noor A Al-Maslamani, Ke Liu, Maria M Meschis, Hazel Sutherland, Peter Wilson, Peter Clegg, Grant N Wheeler, Robert J van ’t Hof, George Bou-Gharios, Kazuhiro Yamamoto

Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration

Edgar M. Pera, Josefine Nilsson-De Moura, Yuriy Pomeshchik, Laurent Roybon, Ivana Milas

Spatiotemporal dynamics of NF-κB/Dorsal inhibitor IκBα/Cactus in Drosophila blastoderm embryos

Allison E. Schloop, Sharva Hiremath, Razeen Shaikh, Cranos M. Williams, Gregory T. Reeves

Spatial Multiomics Reveal the Role of Wnt Modulator, Dkk2, in Palatogenesis

Jeremie Oliver Pina, Resmi Raju, Daniela M Roth, Emma Wentworth Winchester, Cameron Padilla, James Iben, Fabio R Faucz, Justin L Cotney, Rena N D’Souza

Craniofacial studies in chicken embryos confirm the pathogenicity of Frizzled2 variants associated with Robinow syndrome

Shruti S. Tophkhane, Katherine Fu, Esther M. Verheyen, Joy M. Richman

The ciliary protein C2cd3 is required for mandibular musculoskeletal tissue patterning

Evan C. Brooks, Simon J.Y. Han, Christian Louis Bonatto Paese, Amya A. Lewis, Megan Aarnio-Peterson, Samantha A. Brugmann

| Morphogenesis & mechanics

Coupling and uncoupling of midline morphogenesis and cell flow in amniote gastrulation

Rieko Asai, Vivek N. Prakash, Shubham Sinha, Manu Prakash, Takashi Mikawa

Role of Fibronectin in Postnatal Skeletal Development

Neha E. H. Dinesh, Nissan Baratang, Justine Rosseau, Ronit Mohapatra, Ling Li, Ramshaa Mahalingam, Kerstin Tiedemann, Philippe M. Campeau, Dieter P. Reinhardt

Compressive stress drives morphogenetic apoptosis

Tatiana Merle, Martine Cazales, Ronan Bouzignac, Brice Ronsin, Christian Rouvière, Magali Suzanne

A tension-induced morphological transition shapes the avian extra-embryonic territory

Arthur Michaut, Alexander Chamolly, Aurélien Villedieu, Francis Corson, Jérôme Gros

Differential tissue deformability underlies shape divergence of the embryonic brain and spinal cord under fluid pressure

Susannah B.P. McLaren, Shi-Lei Xue, Siyuan Ding, Alex Winkel, Oscar Baldwin, Shreya Dwarakacherla, Kristian Franze, Edouard Hannezo, Fengzhu Xiong

Identification of novel buffering mechanisms in aortic arch artery development and congenital heart disease.

AnnJosette Ramirez, Christina Vyzas, Kevin Eng, Karl Degenhardt, Sophie Astrof

Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

Devon E. Mason, Paula Camacho, Megan E. Goeckel, Brendan R. Tobin, Sebastián L. Vega, Pei-Hsun Wu, Dymonn Johnson, Su-Jin Heo, Denis Wirtz, Jason A. Burdick, Levi Wood, Brian Y. Chow, Amber N. Stratman, Joel D. Boerckel

Signatures of structural disorder in developing epithelial tissues

Christian Cupo, Cole Allan, Vikram Ailiani, Karen E. Kasza

Eph/ephrin signalling in the developing brain is regulated by tissue stiffness

Jana Sipkova, Kristian Franze

An analysis of contractile and protrusive cell behaviours at the superficial surface of the zebrafish neural plate

Claudio Araya, Raegan Boekemeyer, Francesca Farlie, Lauren Moon, Freshta Darwish, Chris Rookyard, Leanne Allison, Gema Vizcay-Barrena, Roland Fleck, Millaray Aranda, Masa Tada, Jonathan D W Clarke

ROCK and the actomyosin network control biomineral growth and morphology during sea urchin skeletogenesis

Eman Hijaze, Tsvia Gildor, Ronald Seidel, Majed Layous, Mark Winter, Luca Bertinetti, Yael Politi, Smadar Ben-Tabou de-Leon

Differential proliferation regulates multi-tissue morphogenesis during embryonic axial extension: Integrating viscous modeling and experimental approaches.

Michele Romanos, Tasha Salisbury, Samuel Stephan, Rusty Lansford, Pierre Degond, Ariane Trescases, Bertrand Benazeraf

Lens Placode Modulates Extracellular Matrix Formation During Early Eye Development

Cecilia Gallottini de Magalhaes, Ales Cvekl, Ruy G. Jaeger, Chao Yun Irene Yan

| Genes & genomes

Sf3b4 mutation in Xenopus tropicalis causes RNA splicing defects followed by massive gene dysregulation that disrupt cranial neural crest development

Casey Griffin, Kelsey Coppenrath, Doha Khan, Ziyan Lin, Marko Horb, Jean-Pierre Saint-Jeannet

hoxb genes determine the timing of cell ingression by regulating cell surface fluctuations during zebrafish gastrulation

Yuuta Moriyama, Toshiyuki Mitsui, Carl-Philipp Heisenberg

Sex-Specific DNA Methylation and Gene Expression Changes in Mouse Placentas After Early Preimplantation Alcohol Exposure

Lisa-Marie Legault, Thomas Dupas, Mélanie Breton-Larrivée, Fannie Filion-Bienvenue, Anthony Lemieux, Alexandra Langford-Avelar, Serge McGraw

miR-203 controls timing of developmental transitions during early preimplantation embryogenesis

José González-Martínez, Estefanía Ayala, Agustín Sanchez-Belmonte, Alejandro García, Enrique Nogueira, Anna Melati, Daniel Gimenez, Ana Losada, Sagrario Ortega, Marcos Malumbres

DNA methylation modulates nucleosome retention in sperm and H3K4 methylation deposition in early mouse embryos

Grigorios Fanourgakis, Laura Gaspa-Toneu, Pavel A. Komarov, Evgeniy A. Ozonov, Sebastien A. Smallwood, Antoine H.F.M. Peters

Developmental pathways underlying sexual differentiation in a U/V sex chromosome system

Daniel Liesner, Guillaume Cossard, Min Zheng, Olivier Godfroy, Josue Barrera-Redondo, Fabian B. Haas, Susana M Coelho

X-chromosome loss rescues Sertoli cell maturation and spermatogenesis in Klinefelter syndrome

Sofia Boeg Winge, Niels E. Skakkebaek, Lise Aksglaede, Guelizar Saritas, Ewa Rajpert-De Meyts, Ellen Goossens, Anders Juul, Kristian Almstrup

HemK2 functions for sufficient protein synthesis and RNA stability through eRF1 methylation during Drosophila oogenesis

Fengmei Xu, Ritsuko Suyama, Toshifumi Inada, Shinichi Kawaguchi, Toshie Kai

Gastrulation-stage gene expression in Nipbl+/- mouse embryos foreshadows the development of syndromic birth defects

Stephenson Chea, Jesse Kreger, Martha E. Lopez-Burks, Adam L. MacLean, Arthur D. Lander, Anne L. Calof

Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

Adriana Karina Alexander, Karina F Rodriguez, Yu-Ying Chen, Ciro Amato, Martin A Estermann, Xin Xu, Humphrey Yao

Epigenetic regulation by TET1 in gene-environmental interactions influencing susceptibility to congenital malformations

Bernard K. van der Veer, Lehua Chen, Spyridon Champeris Tsaniras, Wannes Brangers, Qiuying Chen, Mariana Schroiff, Colin Custers, Harm H.M. Kwak, Rita Khoueiry, Robert Cabrera, Steven S. Gross, Richard H. Finnell, Yunping Lei, Kian Peng Koh

Escape from X inactivation is directly modulated by levels of Xist non-coding RNA

Antonia Hauth, Jasper Panten, Emma Kneuss, Christel Picard, Nicolas Servant, Isabell Rall, Yuvia A. Pérez-Rico, Lena Clerquin, Nila Servaas, Laura Villacorta, Ferris Jung, Christy Luong, Howard Y. Chang, Oliver Stegle, Duncan T. Odom, Agnese Loda, Edith Heard

Spatial patterning of the epigenome during vertebrate gastrulation

Ana Paula Azambuja, Megan Rothstein, Tatiane Y. Kanno, Marcos Simoes-Costa

Rapid response of fly populations to gene dosage across development and generations

Xueying C. Li, Lautaro Gandara, Måns Ekelöf, Kerstin Richter, Theodore Alexandrov, Justin Crocker

Haploidy-linked cell proliferation defects limit larval growth in Zebrafish

Kan Yaguchi, Daiki Saito, Triveni Menon, Akira Matsura, Takeomi Mizutani, Tomoya Kotani, Sreelaja Nair, Ryota Uehara

Temporal Analysis of Pituitary Transcriptional Dynamics in Mice Models of Hypopituitarism During Postnatal Development

Juliana Moreira Marques, Claudia Veiga Chang, Nicholas Silvestre Souza Trigueiro, Ricardo Vieira Araujo, Cinthya dos Santos Cerqueira, Lilian Cristina Russo, Bruna Viscardi Azevedo, Berenice Bilharinho de Mendonca, Nicolas Hoch, Luciani Renata Silveira de Carvalho

A high throughput CRISPR perturbation screen identifies epigenetic regulators impacting primordial germ cell development

Liangdao Li, Xinbao Ding, Alex P. Sheft, John C. Schimenti

A temporal sequence of heterochronic gene activities promotes stage-specific developmental events in C. elegans

Maria Ivanova, Eric G. Moss

| Stem cells, regeneration & disease modelling

Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming

Corey D. Holman, Alexander P. Sakers, Ryan P. Calhoun, Lan Cheng, Ethan C. Fein, Christopher Jacobs, Linus Tsai, Evan D. Rosen, Patrick Seale

foxe1 mutant zebrafish show indications of a hypothyroid phenotype and increased sensitivity to ethanol for craniofacial malformations

Sophie T Raterman, Frank A D T G Wagener, Jan Zethof, Vincent Cuijpers, Peter H M Klaren, Juriaan R Metz, Johannes W. Von den Hoff

Notch is Required for Neural Progenitor Proliferation During Embryonic Eye Regrowth

Dylan J. Guerin, Belen Gutierrez, Baoyi Zhang, Kelly Ai-Sun Tseng

Somite-independent regeneration of the axolotl primary body axis

Wouter Masselink, Tobias Gerber, Francisco Falcon, Tom Deshayes, Sofia-Christina Papadopoulos, Marko Pende, Vijayishwer Singh Jamwal, Yuka Taniguchi-Sugiura, Tzi-Yang Lin, Thomas Kurth, Jingkui Wang, Detlev Arendt, Ji-Feng Fei, Barbara Treutlein, Elly M. Tanaka, Prayag Murawala

HvNotch coordinates two independent pattern forming systems during head regeneration in Hydra by supporting a lateral inhibition process restricting the tentacle system

Mona Steichele, Lara Sauermann, Qin Pan, Jasmin Moneer, Alexandra de la Porte, Martin Heß, Moritz Mercker, Catharina Strube, Marcell Jenewein, Angelika Böttger

Substrate Stiffness Reshapes Layer Architecture and Biophysical Features of Human Induced Pluripotent Stem Cells to Modulate their Differentiation Potential

Jack Llewellyn, Anne Charrier, Emmanuèle Helfer, Rosanna Dono

Hypoxia and TNF-alpha modulate extracellular vesicle release from human induced pluripotent stem cell-derived cardiomyocytes

Margarida Viola, Maarten P. Bebelman, Renee G. C. Maas, Frederik J. Verweij, Cor S. Seinen, Saskia C. A. de Jager, Pieter Vader, D. Michiel Pegtel, Joost P. G. Sluijter

Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids

Yifei Miao, Cheng Tan, Nicole M. Pek, Zhiyun Yu, Kentaro Iwasawa, Daniel O. Kechele, Nambirajan Sundaram, Victor Pastrana-Gomez, Keishi Kishimoto, Min-Chi Yang, Cheng Jiang, Jason Tchieu, Jeffrey A. Whitsett, Kyle W. McCracken, Robbert J. Rottier, Darrell N. Kotton, Michael A. Helmrath, James M. Wells, Takanori Takebe, Aaron M. Zorn, Ya-Wen Chen, Minzhe Guo, Mingxia Gu

Microtubule perturbations of neurite extension and nucleokinesis in an iPSC-derived model system

Muriel Sébastien, Alexandra L. Paquette, Adam G. Hendricks, Gary J. Brouhard

Progressive cell fate specification in morphallactic regeneration

Clara Nuninger, Panagiotis Papasaikas, Jacqueline Ferralli, Sebastien Smallwood, Charisios D. Tsiairis

Novel 3D Approach to Model Non-Alcoholic Fatty Liver Disease using human Pluripotent Stem Cells

Carola Maria Morell, Samantha Grace Tilson, Rute Alexandra Tomaz, Arash Shahsavari, Andi Munteanu, Giovanni Canu, Brandon Tyler Wesley, Marion Perrin, Imbisaat Geti, Subhankar Mukhopadhyay, Francesca Mazzacuva, Paul Gissen, Jose Garcia-Bernardo, Martin Bachman, Casey Allison Rimland, Fotios Sampaziotis, Irina Mohorianu, Ludovic Vallier

Tuning apicobasal polarity and junctional recycling in the hemogenic endothelium orchestrates the morphodynamic complexity of emerging pre-hematopoietic stem cells

Léa Torcq, Sara Majello, Catherine Vivier, Anne A. Schmidt

Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammation

Pauline Garcia, William Jarassier, Caroline Brun, Lorenzo Giordani, Fany Agostini, Wai Hing Kung, Cécile Peccate, Jade Ravent, Sidy Fall, Valentin Petit, Tom H Cheung, Slimane Ait-Si-Ali, Fabien Le Grand

Loss of UBE3A impacts both neuronal and non-neuronal cells in human cerebral organoids

R. Chris Estridge, Z. Begum Yagci, Dilara Sen, Travis S. Ptacek, Jeremy M. Simon, Albert J. Keung

Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency

Chikako Okubo, Michiko Nakamura, Masae Sato, Yuichi Shichino, Mari Mito, Yasuhiro Takashima, Shintaro Iwasaki, Kazutoshi Takahashi

Developmental emergence of quiescent-like neural progenitor cells in the zebrafish embryonic brain

Yuanyuan Liu, Carla-Sophie Lembke, Judith TML Paridaen

The Drosophila histone methyl-transferase SET1 coordinates multiple signaling pathways in regulating male germline stem cell maintenance and differentiation

Velinda Vidaurre, Annabelle Song, Taibo Li, Wai Lim Ku, Keji Zhao, Jiang Qian, Xin Chen

Characterization of Pro-Fibrotic Signaling Pathways using Human Hepatic Organoids

Yuan Guan, Zhuoqing Fang, Angelina Hu, Sarah Roberts, Meiyue Wang, Wenlong Ren, Patrik K. Johansson, Sarah C. Heilshorn, Annika Enejder, Gary Peltz

Axolotl mandible regeneration occurs through mechanical gap closure and a shared regenerative program with the limb

Julia Kramer, Rita Aires, Sean D. Keeley, Tom Alexander Schröder, Günter Lauer, Tatiana Sandoval-Guzmán

Resistance to Naïve and Formative Pluripotency Conversion in RSeT Human Embryonic Stem Cells

Kevin G. Chen, Kory R. Johnson, Kyeyoon Park, Dragan Maric, Forest Yang, Wen Fang Liu, Yang C. Fann, Barbara S. Mallon, Pamela G. Robey

Licensing and competition of stem cells at the niche combine to regulate tissue maintenance

Rodrigo Garcia-Tejera, Marc Amoyel, Ramon Grima, Linus Schumacher

Clonal analysis of fetal hematopoietic stem/progenitor cell subsets reveals how post-transplantation capabilities are distributed

Olivia Stonehouse, Christine Biben, Tom S Weber, Alexandra Garnham, Katie Fennell, Alison Farley, Antoine Terreaux, Warren Alexander, Mark Dawson, Shalin Naik, Samir Taoudi

DDR1 regulates RUNX1-CBFβ to control breast stem cell differentiation

Colin Trepicchio, Gat Rauner, Nicole Traugh, Meadow Parrish, Daniel E.C. Fein, Youssof Mal, Charlotte Kuperwasser

Mitotic Block and Epigenetic Repression Underlie Neurodevelopmental Defects and Neurobehavioral Deficits in Congenital Heart Disease

George C. Gabriel, Hisato Yagi, Tuantuan Tan, Abha S. Bais, Benjamin J. Glennon, Margaret C. Stapleton, Lihua Huang, William T. Reynolds, Marla G. Shaffer, Madhavi Ganapathiraju, Dennis Simon, Ashok Panigrahy, Yijen L. Wu, Cecilia W. Lo

TASOR expression in naive embryonic stem cells safeguards their developmental potential

Carlos A. Pinzon-Arteaga, Ryan O’Hara, Alice Mazzagati, Emily Ballard, Yingying Hu, Alex Pan, Daniel A. Schmitz, Yulei Wei, Masahiro Sakurai, Peter Ly, Laura Banaszynski, Jun Wu

Stereotyped cell lineage trees support robust development

Xiaoyu Zhang, Zizhang Li, Jingyu Chen, Wenjing Yang, Peng Wu, Feng Chen, Xingxing He, Xiaoshu Chen, Jian-Rong Yang

The Mayo Clinic Salivary Tissue-Organoid Biobanking: A Resource for Salivary Regeneration Research

Syed Mohammed Musheer Aalam, Ana Rita Varela, Aalim Khaderi, Ronsard J Mondesir, Dong-Gi Mun, Andrew Ding, Isabelle M.A. Lombaert, Rob P. Coppes, Chitra Priya Emperumal, Akhilesh Pandey, Jeffrey R. Janus, Nagarajan Kannan

Local ecdysone synthesis in a wounded epithelium sustains developmental delay and promotes regeneration in Drosophila

Douglas Terry, Colby Schweibenz, Kenneth Moberg

| Plant development

Modular mechanisms of immune priming and growth inhibition mediated by plant effector-triggered immunity

Himanshu Chhillar, Pei-Min Yeh, Hoang Hung Nguyen, Jonathan DG Jones, Pingtao Ding

Receptor kinase LecRK-I.9 regulates cell wall remodelling and signalling during lateral root formation in Arabidopsis

Kevin Bellande, David Roujol, Josiane Chourré, Sophie Le Gall, Yves Martinez, Alain Jauneau, Vincent Burlat, Elisabeth Jamet, Hervé Canut

Twilight length alters growth and flowering time in Arabidopsis via LHY/CCA1

Devang Mehta, Sabine Scandola, Curtis Kennedy, Christina Lummer, Maria Camila Rodriguez Gallo, Lauren E. Grubb, Maryalle Tan, Enrico Scarpella, R. Glen Uhrig

A shade-responsive microProtein in the Arabidopsis ATHB2 gene regulates elongation growth and root development

Ashleigh Edwards, Maurizio Junior Chiurazzi, Anko Blaakmeer, Ylenia Vittozzi, Ashish Sharma, Sanne Matton, Valdeko Kruusvee, Daniel Straub, Giovanna Sessa, Monica Carabelli, Giorgio Morelli, Stephan Wenkel

Tyrosine-sulfated peptide hormone induces flavonol biosynthesis to control elongation and differentiation in Arabidopsis primary root

Maria Florencia Ercoli, Alexandra M. Shigenaga, Artur Teixeira de Araujo Jr, Rashmi Jain, Pamela C. Ronald

Understanding Regeneration: investigating the apical notch and meristem re-emergence in Marchantia polymorpha

Alan O. Marron, Marius Rebmann, Mihails Delmans, Jim Haseloff

OsNF-YB7 inactivates OsGLK1 to inhibit chlorophyll biosynthesis in rice embryo

Zongju Yang, Tianqi Bai, E Zhiguo, Baixiao Niu, Chen Chen

Spatial transcriptomics reveals distinct lineage identities for major and minor vein initiation during maize leaf development

Chiara Perico, Maricris Zaidem, Olga Sedelnikova, Samik Bhattacharya, Christian Korfhage, Jane A. Langdale

Geometry and cell wall mechanics guide early pollen tube growth in Arabidopsis thaliana

Lucie Riglet, Catherine Quilliet, Christophe Godin, Karin John, Isabelle Fobis-Loisy

Medicago truncatula ABCG40 is a cytokinin importer that negatively regulates lateral root density and nodule number

Tomasz Jamruszka, Joanna Banasiak, Aleksandra Pawela, Karolina Jarzyniak, Jian Xia, Wanda Biała-Leonhard, Lenka Plačková, Tashi Tsering, Francesca Romana Iacobini, Ondřej Novák, Markus Geisler, Michał Jasiński

ABCC10 roles in plant development and the transport of indole-3-butyric acid

Arielle L. Homayouni, Suresh Damodaran, Katherine Schreiber, Marta Michniewicz, Lauren K. Gunther, Lucia C. Strader

A shade-responsive microProtein in the Arabidopsis ATHB2 gene regulates elongation growth and root development

Ashleigh Edwards, Maurizio Junior Chiurazzi, Anko Blaakmeer, Ylenia Vittozzi, Ashish Sharma, Sanne Matton, Valdeko Kruusvee, Daniel Straub, Giovanna Sessa, Monica Carabelli, Giorgio Morelli, Stephan Wenkel

The ELF3-BBX24/BBX25-PIF4 module controls thermosensory growth in Arabidopsis

Bidhan Chandra Malakar, Shivani Singh, Vikas Garhwal, Gouranga Upadhyaya, Rajanesh Chandramohan, Sreeramaiah N. Gangappa

Characterization of gelling agents in callus inducing media: Physical properties and their effect on callus development

Noy Sadot Muzika, Tamir Kamai, Leor Eshed Williams, Maya Kleiman

Young guard cells function dynamically despite low mechanical anisotropy but gain efficiency during stomatal maturation in Arabidopsis thaliana

Leila Jaafar, Yintong Chen, Sedighe Keynia, Joseph A Turner, Charles T Anderson

The DC1 domain protein Vacuoleless Gametophytes regulates stamen development in Arabidopsis

Natalia L. Amigo, Leonardo A. Arias, Fernanda Marchetti, Sebastián D’Ippólito, Jesica Frik, María Cristina Lombardo, María Cecilia Terrile, Claudia A. Casalongue, Gabriela C. Pagnussat, Diego F. Fiol

Stomatal patterning is differently regulated in adaxial and abaxial epidermis in Arabidopsis

Pirko Jalakas, Ingmar Tulva, Nele Malvīne Bērziņa, Hanna Hõrak

Overexpressing NRT2.7 induces nitrate export from the vacuole and increases growth of Arabidopsis

Patrick Armengaud, Alexis De Angeli, Patrick Berquin, Virginie Bréhaut, Mickaël Durand, Françoise Daniel-Vedele, Anne Krapp, Sophie Filleur

SHOOTMERISTEMLESS autoactivation: A prerequisite for fruit metamorphosis

Yang Dong, Zhi-Cheng Hu, Mateusz Majda, Hao-Ran Sun, Yao Zhang, Yi-Ning Ding, Quan Yuan, Tong-Bing Su, Tian-Feng Lü, Feng Gao, Gui-Xia Xu, Richard S. Smith, Lars Østergaard

| Evo-devo

Potential role of microRNAs in regulating transcriptional profile, and sculpting development and metabolism in cavefish

Tathagata Biswas, Huzaifa Hassan, Nicolas Rohner

Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae

Christopher R. L. Large, Rupa Khanal, LaDeana Hillier, Chau Huynh, Connor Kubo, Junhyong Kim, Robert H. Waterston, John I. Murray

Insights into ontogenetic scaling and morphological variation in sharks from near-term brown smooth-hound (Mustelus henlei) embryos

Joel H. Gayford, Phillip C. Sternes, Scott G. Seamone, Hana Godfrey, Darren A. Whitehead

Changing rounds into squares or combining stripes: Diversity and formation of checkerboard patterns in Eukaryotes

Pierre Galipot, Julie Zalko

Bats of a feather: Range characteristics and wing morphology predict phylogeographic breaks in volant vertebrates

Sydney K Decker, Kaiya L Provost, Bryan C Carstens

The ivory lncRNA regulates seasonal color patterns in buckeye butterflies

Richard A Fandino, Noah K Brady, Martik Chatterjee, Jeanne Marie Chan McDonald, Luca Livraghi, Karin van der burg, Anyi Mazo-Vargas, Robert D. Reed

Polygenic architecture of adaptation to a high-altitude environment for Drosophila melanogaster wing shape and size.

Katie Pelletier, Megan Bilodeau, Isabella Pellizzari-Delano, M. Daniel Siemon, Yuheng Huang, John E. Pool, Ian E Dworkin

Eyespots originated multiple times independently across the Lepidoptera

Brian Hanotte, Beatriz Willink, Antónia Monteiro

Rapid growth and the evolution of complete metamorphosis in insects

Christin Manthey, C Jessica E Metcalf, Michael T Monaghan, Ulrich Karl Steiner, Jens Rolff

Inferring a role for programmed cell death during the origin and evolution of wing polyphenism in ants

Lisa Hanna, Brendon E. Boudinot, Jürgen Liebig, Ehab Abouheif

mirror determines the far posterior domain in butterfly wings

Martik Chatterjee, Xin Y. Yu, Noah K. Brady, Gabriel C. Hatto, Robert D. Reed

Cephalopod Sex Determination and its Ancient Evolutionary Origin Revealed by Chromosome-level Assembly of the California two-spot Octopus

Gabrielle C. Coffing, Silas Tittes, Scott T. Small, Jeremea O. Songco-Casey, Denise M. Piscopo, Judit R. Pungor, Adam C Miller, Cristopher Niell, Andrew D. Kern

Cell Biology

Cell cycle variants during Drosophila accessory gland development

Allison M. Box, Navyashree A. Ramesh, Shyama Nandakumar, Samuel Jaimian Church, Dilan Prasad, Ariana Afrakhteh, Russell S. Taichman, Laura Buttitta

Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes

Elena D. Christofidou, Marios Tomazou, Chrysovalantis Voutouri, Christina Michael, Triantafyllos Stylianopoulos, George M. Spyrou, Katerina Strati

Plasmodium NEK1 coordinates MTOC organisation and kinetochore attachment during rapid mitosis in male gamete formation

Mohammad Zeeshan, Ravish Rashpa, David J. Ferguson, George Mckeown, Raushan Nugmanova, Amit K. Subudhi, Raphael Beyeler, Sarah L. Pashley, Robert Markus, Declan Brady, Magali Roques, Andrew R. Bottrill, Andrew M. Fry, Arnab Pain, Sue Vaughan, Anthony A. Holder, Eelco C. Tromer, Mathieu Brochet, Rita Tewari

Nutritional sex-specificity on bacterial metabolites during mosquito development leads to adult sex-ratio distortion

Ottavia Romoli, Javier Serrato-Salas, Chloé Gapp, Yanouk Epelboin, Pol Figueras Ivern, Frédéric Barras, Mathilde Gendrin

IL-1β disrupts blood-brain barrier development by inhibiting endothelial Wnt/β-catenin signaling

Audrey R. Fetsko, Dylan J. Sebo, Lilyana B. Budzynski, Alli Scharbarth, Michael R. Taylor

Loss of the mitochondrial citrate carrier, Slc25a1/CIC disrupts embryogenesis via 2-Hydroxyglutarate

Anna Kasprzyk-Pawelec, Mingjun Tan, Yu Leng Phua, Raneen Rahhal, Alec McIntosh, Harvey Fernandez, Rami Mosaoa, Michael Girgis, Amrita Cheema, Lei Jiang, Lawrence F. Kroemer, Anastas Popratiloff, Cheryl Clarkson, Brian M. Kirmsa, Gray W. Pearson, Eric Glasgow, Christopher Albanese, Jerry Vockley, Maria Laura Avantaggiati

Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination

Ruonan Zhao, Emma L. Moore, Madelaine M Gogol, Jay R. Unruh, Zulin Yu, Allison Scott, Yan Wang, Naresh Kumar Rajendran, Paul A. Trainor

Truncated NLRC5 isoforms in human placenta: expression, regulation by miR-218-5p, and function in trophoblasts

Yanan Shan, Jacob A O’Brian, Lubna Nadeem, Caroline Dunk, Yan Chen, Jelena Brkic, Heyam Hayder, Stephen J Lye, Chun Peng

The transmembrane protein Syndecan regulates stem cell nuclear properties and cell maintenance

Buffy L. Eldridge-Thomas, Jerome G. Bohere, Chantal Roubinet, Alexandre Barthelemy, Tamsin J. Samuels, Felipe Karam Teixeira, Golnar Kolahgar

Innervation of cranial muscles requires Mllt11/Af1q/Tcf7c function during trigeminal ganglion development

Nicholas W. Zinck, Danielle Stanton-Turcotte, Emily A. Witt, Marley Bloomers, Angelo Iulianella

Filamin A mediates embryonical palatal fusion by linking mechanotransduction with β-Catenin/Smad2

Ziyi Wang, Satoru Hayano, Yao Weng, Xindi Mu, Mitsuaki Ono, Jeremie Oliver Piña, Rena N. D’Souza, Takashi Yamashiro, Toshitaka Oohashi, Hiroshi Kamioka

The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the Drosophila CNS

Sanjay Kumar Sukumar, Vimala Antonydhason, Linnea Molander, Jawdat Sandakly, Malak Kleit, Ganesh Umapathy, Patricia Mendoza-Garcia, Tafheem Masudi, Andreas Schlossser, Dick R. Nässel, Christian Wegener, Margret Shirinian, Ruth H. Palmer

Antagonistic Roles of Tau and MAP6 in Regulating Neuronal Development

Xiaohuan Sun, Wenqian Yu, Peter W. Baas, Kazuhito Toyooka, Liang Qiang

Placental cytotrophoblast microvillar stabilization is required for cell-cell fusion

Wendy K. Duan, Sumaiyah Z. Shaha, Khushali J. Patel, Ivan K. Domingo, Meghan R. Riddell

Control of ciliary transcriptional programs during spermatogenesis by antagonistic transcription factors

Weihua Wang, Junqiao Xing, Xiqi Zhang, Hongni Liu, Haochen Jiang, Cheng Xu, Xue Zhao, Zhangfeng Hu

Novel Nuclear Roles for Testis-Specific ACTL7A and ACTL7B Supported by In Vivo Characterizations and AI Facilitated In Silico Mechanistic Modeling with Implications for Epigenetic Regulation in Spermiogenesis.

Pierre Ferrer, Srijana Upadhyay, James Cai, Tracy M Clement

Modelling

Rapid growth and the evolution of complete metamorphosis in insects

Christin Manthey, Jessica CE Metcalf, Michael T Monaghan, Ulrich Karl Steiner, Jens Rolff

Modularity of the segmentation clock and morphogenesis

James E. Hammond, Ruth E. Baker, Berta Verd

Deep Learning Based Models for Preimplantation Mouse and Human Development

Martin Proks, Nazmus Salehin, Joshua M. Brickman

Novel mathematical morphology model identifies dorsal-ventral asymmetry of endothelial cell morphology in dorsal aorta of wild-type and Endoglin-deficient zebrafish embryos

Daniel Seeler, Nastasja Grdseloff, Claudia Jasmin Rödel, Charlotte Kloft, Salim Abdelilah-Seyfried, Wilhelm Huisinga

A quantitative model for in vivo stem cell decisions in planarians

Tamar Frankovits, Prakash Varkey Cherian, Yarden Yesharim, Simon Dobler, Omri Wurtzel

Tools & Resources

A Comprehensive Human Embryogenesis Reference Tool using Single-Cell RNA-Sequencing Data

Cheng Zhao, Alvaro Plaza Reyes, John Paul Schell, Jere Weltner, Nicolás M. Ortega, Yi Zheng, Åsa K. Björklund, Laura Baqué-Vidal, Joonas Sokka, Ras Torokovic, Brian Cox, Janet Rossant, Jianping Fu, Sophie Petropoulos, Fredrik Lanner

A Genetic Screen for regulators of CNS morphology in Drosophila

Haluk Lacin, Yuqing Zhu, Jose DiPaola, Beth A. Wilson, Yi Zhu, James B. Skeath

NeuroTri2-VISDOT: An open-access tool to harness the power of second trimester human single cell data to inform models of Mendelian neurodevelopmental disorders

Kelly J. Clark, Emily E. Lubin, Elizabeth M. Gonzalez, Annabel K. Sangree, Dana E. Layo-Carris, Emily L. Durham, Rebecca C. Ahrens-Nicklas, Tomoki T. Nomakuchi, Elizabeth J. Bhoj

Single-cell and bulk transcriptional profiling of mouse ovaries reveals novel genes and pathways associated with DNA damage response in oocytes

Monique Mills, Chihiro Emori, Parveen Kumar, Zachary Boucher, Joshy George, Ewelina Bolcun-Filas

Single-cell and spatial transcriptomics of the avian embryo tailbud

GF Mok, S Turner, E Smith, L Mincarelli, A Lister, J Lipscombe, V Uzun, W Haerty, IC Macaulay, A Münsterberg

Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo

Taro Ichimura, Taishi Kakizuka, YuKi Sato, Keiko Itano, Kaoru Seiriki, Hitoshi Hashimoto, Hiroya Itoga, Shuichi Onami, Takeharu Nagai

High-throughput identification of the spatial origins of Drosophila optic lobe neurons using single-cell mRNA-sequencing

Félix Simon, Isabel Holguera, Yen-Chung Chen, Jennifer Malin, Priscilla Valentino, Ted Erclik, Claude Desplan

A single-cell 3D spatiotemporal multi-omics atlas from Drosophila embryogenesis to metamorphosis

Mingyue Wang, Qinan Hu, Zhencheng Tu, Lingshi Kong, Jiajun Yao, Rong Xiang, Zhan Chen, Yan Zhao, Yanfei Zhou, Tengxiang Yu, Yuetian Wang, Zihan Jia, Kang Ouyang, Xianzhe Wang, Yinqi Bai, Mingwei Lian, Zhenyu Yang, Tao Yang, Jing Chen, Yunting Huang, Ni Yin, Wenyuan Mo, Wenfu Liang, Chang Liu, Xiumei Lin, Chuanyu Liu, Ying Gu, Wei Chen, Longqi Liu, Xun Xu, Yuhui Hu

The Guinea Pig: A New Model for Human Preimplantation Development

Jesica Romina Canizo, Cheng Zhao, Sophie Petropoulos

Decoding morphogen patterning of human neural organoids with a multiplexed single-cell transcriptomic screen

Fátima Sanchís-Calleja, Akanksha Jain, Zhisong He, Ryoko Okamoto, Charlotte Rusimbi, Pedro Rifes, Gaurav Singh Rathore, Malgorzata Santel, Jasper Janssens, Makiko Seimiya, Jonas Simon Fleck, Agnete Kirkeby, J. Gray Camp, Barbara Treutlein

A double ovulation protocol for Xenopus laevis produces doubled fertilisation yield and moderately transiently elevated corticosterone levels without loss of egg quality

Chloe Moss, Barbara Vacca, Jo Arnold, Chantal Hubens, Dominic M. Lynch, James Pegge, Michael A.R. Green, Charlotte A. Hosie, Tessa E. Smith, Jeremy B.A. Green

A screen of mutants generated and imaged by the International Mouse Phenotyping Consortium identifies 39 novel genes regulating the development of the secondary palate.

Ashwin Bhaskar, Sophie Astrof

Induction and in silico staging of human gastruloids with neural tube, segmented somites & advanced cell types

Nobuhiko Hamazaki, Wei Yang, Connor Kubo, Chengxiang Qiu, Beth K Martin, Riddhiman K Garge, Samuel G Regalado, Eva Nichols, Choli Lee, Riza M Daza, Sanjay Srivatsan, Jay Shendure

Scalable and Efficient Generation of Mouse Primordial Germ Cell-like Cells

Xinbao Ding, Liangdao Li, Jingyi Gao, Dain Yi, John C Schimenti

PCP Auto Count: A Novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting

Kendra L. Stansak, Luke D. Baum, Sumana Ghosh, Punam Thapa, Vineel Vanga, Bradley J. Walters

morphoHeart: a novel quantitative tool to perform integrated 3D morphometric analyses of heart and ECM morphology during embryonic development

Juliana Sánchez-Posada, Emily S Noël

Nuclear instance segmentation and tracking for preimplantation mouse embryos

Hayden Nunley, Binglun Shao, David Denberg, Prateek Grover, Jaspreet Singh, Maria Avdeeva, Bradley Joyce, Rebecca Kim-Yip, Abraham Kohrman, Abhishek Biswas, Aaron Watters, Zsombor Gal, Alison Kickuth, Madeleine Chalifoux, Stanislav Shvartsman, Lisa M. Brown, Eszter Posfai

A single-cell transcriptomics atlas for the parasitic nematode Heligmosomoides bakeri: Extrapolating model organism information to non-model systems

Stephen M J Pollo, Hongrui Liu, Aralia Leon Coria, Nicole Rosin, Elodie Labit, Jeff Biernaskie, Constance A M Finney, James D Wasmuth

Research practice & education

Structured Peer Review: Pilot results from 23 Elsevier Journals

Mario Malički, Bahar Mehmani

Sci-comm “behind the scenes”: Gendered narratives of scientific outreach activities in the life sciences

Perry G Beasley-Hall, Pam Papadelos, Anne Hewitt, Kate D L Umbers, Michelle T Guzik

Nationwide Inclusive Facilitator Training: Mindsets, Practices and Growth

Diane Codding, Alexandria H. Yen, Haley Lewis, Vanessa Johnson-Ojeda, Regina F. Frey, Sarah Chobot Hokanson, Bennett B. Goldberg

Postdoctoral Scholar Recruitment and Hiring Practices in STEM: A Pilot Study

Meagan Heirwegh, Douglas C. Rees, Lindsey Malcom-Piqueux

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