Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints.

The preprints this month are hosted on bioRxiv and arXiv – use these links below to get to the section you want:

Developmental biology

• Patterning & signalling
• Morphogenesis & mechanics
• Genes & genomes
• Stem cells, regeneration & disease modelling
• Plant development
• Evo-devo

Cell Biology

Modelling

Tools & Resources

Developmental biology

| Patterning & signalling

Unravelling the progression of the zebrafish primary body axis with reconstructed spatiotemporal transcriptomics

Yang Dong, Tao Cheng, Xiang Liu, Xin-Xin Fu, Yang Hu, Xian-Fa Yang, Ling-En Yang, Hao-Ran Li, Zhi-Wen Bian, Naihe Jing, Jie Liao, Xiaohui Fan, Peng-Fei Xu

Non-autonomous insulin signaling regulates the duration of mitosis in C. elegans germline stem and progenitor cells

Eric Cheng, Ran Lu, Abigail R. Gerhold

Early Embryonic Development of the German Cockroach Blattella germanica

Ariel Bar-Lev Viterbo, Judith R. Wexler, Orel Mayost Lev-Ari, Ariel D. Chipman

An avidity-driven mechanism of extracellular BMP regulation by Twisted gastrulation

Gareth Moore, Lauren Forbes-Beadle, Holly Birchenough, Clair Baldock, Hilary L Ashe

GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis

Joseph A. Bisson, Miriam Gordillo, Ritu Kumar, Neranjan de Silva, Ellen Yang, Kelly M. Banks, Zhong-Dong Shi, Kihyun Lee, Dapeng Yang, Wendy K. Chung, Danwei Huangfu, Todd Evans

Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids

Kyoung Jo, Zong-Yuan Liu, Gauri Patel, Zhiyuan Yu, LiAng Yao, Seth Teague, Craig Johnson, Jason Spence, Idse Heemskerk

A Retinoic Acid:YAP1 signaling axis controls atrial lineage commitment

Elizabeth Abraham, Brett Volmert, Thomas Roule, Ling Huang, Jingting Yu, April E. Williams, Henry M. Cohen, Aidan Douglas, Emily Megill, Alex Morris, Eleonora Stronati, Raquel Fueyo, Mikel Zubillaga, John W. Elrod, Naiara Akizu, Aitor Aguirre, Conchi Estaras

Glycolytic flux controls retinal progenitor cell differentiation via regulating Wnt signaling

Joseph Hanna, Yacine Touahri, Alissa Pak, Lauren Belfiore, Edwin van Oosten, Luke Ajay David, Sisu Han, Yaroslav Ilnytskyy, Igor Kovalchuk, Deborah M Kurrasch, Satoshi Okawa, Antonio del Sol, Robert A Screaton, Isabelle Aubert, Carol Schuurmans

Permissive and instructive Hox codes govern limb positioning

Yajun Wang, Maik Hintze, Jinbao Wang, Patrick Petzsch, Karl Köhrer, Hengxun Tao, Longfei Cheng, Peng Zhou, Jianlin Wang, Zhaofu Liao, Xufeng Qi, Dongqing Cai, Thomas Bartolomaeus, Karl Schilling, Joerg Wilting, Stefanie Kuerten, Georgy Koentges, Ketan Patel, Qin Pu, Ruijin Huang

Shaping and interpretation of Dpp morphogen gradient by endocytic trafficking

Sheida Hadji Rasouliha, Gustavo Aguilar, Cindy Reinger, Shinya Matsuda

Pulsatile dynamics propagate crystalline order in the developing Drosophila eye

Lydie Couturier, Juan Luna-Escalante, Khallil Mazouni, Claire Mestdagh, Minh-Son Phan, Jean-Yves Tinevez, François Schweisguth, Francis Corson

FGF Signaling Regulates Development of the Anterior Fontanelle

Lauren Bobzin, Audrey Nickle, Sebastian Ko, Michaela Ince, Arshia Bhojwani, Amy E. Merrill

NR2F2 is required in the embryonic testis for Fetal Leydig Cell development

Aitana Perea-Gomez, Natividad Bellido-Carreras, Magali Dhellemmes, Furong Tang, Coralie Le Gallo, Marie-Christine Chaboissier

Spatial ciliary signaling regulates the dorsal/ventral regionalization of human brain organoids

Issei S. Shimada, Akari Goto, Yutaka Hashimoto, Hiroshi Takase, Masayuki Itoh, Yoichi Kato

Atypical soluble guanylyl cyclases control brain size in Drosophila

Daniel Prieto, Boris Egger, Rafael Cantera

Conserved signals orchestrate self-organization and symmetry breaking of bi-layered epithelia during development and regeneration

Robin P. Journot, Mathilde Huyghe, Alexandre Barthelemy, Hugo Couto-Moreira, Jakub Sumbal, Marisa M. Faraldo, Maxime Dubail, Charles Fouillade, Silvia Fre

ETV4 and ETV5 Orchestrate FGF-Mediated Lineage Specification and Epiblast Maturation during Early Mouse Development

Claire S Simon, Vidur Garg, Ying-Yi Kuo, Kathy K Niakan, Anna-Katerina Hadjantonakis

A whole-body atlas of non-graded BMP signaling activity in a sea anemone

Paul Knabl, David Moersdorf, Grigory Genikhovich

| Morphogenesis & mechanics

Endothelial Zmiz1 modulates physiological and pathophysiological angiogenesis during retinal development

Nehal R Patel, Rajan K C, Mark Y Chiang, Stryder M Meadows

Prickle2 regulates apical junction remodeling and tissue fluidity during vertebrate neurulation

Miho Matsuda, Sergei Y. Sokol

Substrate Rigidity Modulates Segmentation Clock Dynamics in Isolated Presomitic Mesoderm Cells

Chun-Yen Sung, Usha Kadiyala, Owen Blanchard, Liam Yourston, Derek Walker, Linyuan Li, Jianping Fu, Qiong Yang

Migration of Kupffer’s vesicle derived cells is essential for tail morphogenesis in zebrafish embryos

Jelmer Hoeksma, Jeroen den Hertog

Algal growth and morphogenesis-promoting factors released by cold-adapted bacteria contribute to the resilience and morphogenesis of the seaweed Ulva (Chlorophyta) in Antarctica (Potter Cove)

Fatemeh Ghaderiardakani, Johann F. Ulrich, Emanuel Barth, Maria Liliana Quartino, Thomas Wichard

Mechanosensitive PIEZO2 channels shape coronary artery development

Mireia Pampols-Perez, Carina Fürst, Oscar Sánchez-Carranza, Elena Cano, Sandra Raimundo, Eric L. Lindberg, Martin Taube, Arnd Heuser, Anje Sporbert, Norbert Hübner, Holger Gerhardt, Gary R. Lewin, Annette Hammes

Muscle and intestine innexins with muscle Deg/Enac channels promote muscle coordination and embryo elongation

Flora Llense, Teresa Ferraro, Xinyi Yang, Hanla Song, Michel Labouesse

EPHA1 and EPHB4 tyrosine kinase receptors regulate epithelial morphogenesis

Noemie Lavoie, Anaelle Scribe, Francois JM Chartier, Karim Ghani, Alexandra Jette, Sara L Banerjee, Manuel Caruso, Melanie Laurin, Andrew Freywald, Sabine Elowe, Patrick Laprise, Nicolas Bisson

The longitudinal growth of the embryo of the kelp Saccharina depends on actin filaments that control the formation of an alginate corset in the cell wall

Samuel Boscq, Ioannis Theodorou, Roman Milstein, Aude Le Bail, Sabine Chenivesse, Bernard Billoud, Benedicte Charrier

Dynamical forces drive organ morphology changes during embryonic development

Raj Kumar Manna, Emma M. Retzlaff, Anna Maria Hinman, Yiling Lan, Osama Abdel-Razek, Mike Bates, Heidi Hehnly, Jeffrey D. Amack, M. Lisa Manning

Adult caudal fin shape is imprinted in the embryonic fin fold

Eric Surette, Joan Donahue, Stephanie Robinson, Deirdre McKenna, Crisvely Soto Martinez, Brendan Fitzgerald, Rolf O. Karlstrom, Nicolas Cumplido, Sarah K. McMenamin

Mll4 regulates postnatal palate growth and midpalatal suture development

Jung-Mi Lee, Hunmin Jung, de Paula Machado Pasqua Bruno, Yungki Park, Shin Jeon, Soo-Kyung Lee, Jae W. Lee, Hyuk-Jae Edward Kwon

Embryo movement is required for limb tendon maturation

Rebecca A. Rolfe, Ebru Talak Busturkmen, Lauren Sliney, Grace Hayden, Nicholas Dunne, Niamh Buckley, Helen McCarthy, Spencer E. Szczesny, Paula Murphy

Tbx1 stabilizes differentiation of the cardiopharyngeal mesoderm and drives morphogenesis in the pharyngeal apparatus

Olga Lanzetta, Marchesa Bilio, Johannes Liebig, Katharina Jechow, Foo Wei Ten, Rosa Ferrentino, Ilaria Aurigemma, Elizabeth Illingworth, Christian Conrad, Soeren Lukassen, Claudia Angelini, Antonio Baldini

Multiscale mechanics drive functional maturation of the vertebrate heart

Toby GR Andrews, Jake Cornwall Scoones, Marie-Christine Ramel, Kirti Gupta, James Briscoe, Rashmi Priya

Stem cell mechanoadaptation – Part A – Effect of microtubule stabilization and volume changing stresses on cytoskeletal remodeling

Vina D. L. Putra, Kristopher A. Kilian, Melissa L. Knothe Tate

The dual Ras Association (RA) Domains of Drosophila Canoe have differential roles in linking cell junctions to the cytoskeleton during morphogenesis

Emily D. McParland, Noah J. Gurley, Leah R. Wolfsberg, T. Amber Butcher, Abhi Bhattarai, Corbin C. Jensen, Ruth I. Johnson, Kevin C. Slep, Mark Peifer

| Genes & genomes

Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation

Saira Amir, Olatunbosun Arowolo, Ekaterina Mironova, Joseph McGaunn, Oladele Oluwayiose, Oleg Sergeyev, J. Richard Pilsner, Alexander Suvorov

The CCT chaperonin and actin modulate the ER and RNA-binding protein condensation during oogenesis to maintain translational repression of maternal mRNA and oocyte quality

Mohamed T. Elaswad, Mingze Gao, Victoria E. Tice, Cora G. Bright, Grace M. Thomas, Chloe Munderloh, Nicholas J. Trombley, Christya N. Haddad, Ulysses G. Johnson, Ashley N. Cichon, Jennifer A. Schisa

SEM-2/SoxC regulates multiple aspects of C. elegans postembryonic mesoderm development

Marissa Baccas, Vanathi Ganesan, Amy Leung, Lucas Pineiro, Alexandra N. McKillop, Jun Liu

miR-184 controls Dilp8 to regulate pupariation timing in response to developmental perturbations in Drosophila melanogaster

Jervis Fernandes, Muhammed Naseem, Ayisha Marwa MP, Jishy Varghese

Deletion of an evolutionarily conserved TAD boundary compromises spermatogenesis in mice

Ana C. Lima, Mariam Okhovat, Alexandra M. Stendahl, Jake VanCampen, Kimberly A. Nevonen, Jarod Herrera, Weiyu Li, Lana Harshman, Ran Yang, Lev M. Fedorov, Katinka A. Vigh-Conrad, Nadav Ahituv, Donald F. Conrad, Lucia Carbone

PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

Julia Raulino Lima, Nicha Ungvijanpunya, Qing Chen, Greg Park, Mohammadreza Vatankhah, Tal Rosen, Yang Chai, Amy Merrill-Brugger, Weiqun Peng, Jian Xu

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate

Harold Marin, Eric Simental, Charlie Allen, Eric Martin, Barbara Panning, Bassem Al-Sady, Abigail Buchwalter

Transcriptomic analysis of meiotic genes during the mitosis-to-meiosis transition in Drosophila females

Ana Maria Vallés, Thomas Rubin, Nicolas Macaisne, Laurine Dal Toe, Anahi Molla-Herman, Christophe Antoniewski, Jean-René Huynh

METTL3 shapes m6A epitranscriptomic landscape for successful human placentation

Ram Parikshan Kumar, Rajnish Kumar, Avishek Ganguly, Ananya Ghosh, Soma Ray, Md. Rashedul Islam, Abhik Saha, Namrata Roy, Purbasa Dasgupta, Taylor Knowles, Asef Jawad Niloy, Courtney Marsh, Soumen Paul

Dysregulation of gene expression during gastrulation results in impaired primitive erythropoiesis and vascular development in Trim71-KO embryos

Tobias Beckröge, Bettina Jux, Hannah Seifert, Hannah Theobald, Elena De Domenico, Stefan Paulusch, Marc Beyer, Andreas Schlitzer, Elvira Mass, Waldemar Kolanus

Elp1 function in placode-derived neurons is critical for proper trigeminal ganglion development

Margaret A Hines, Lisa A Taneyhill

Lineage-specific genomic imprinting in the ZNF791 locus

Jinsoo Ahn, In-Sul Hwang, Mi-Ryung Park, Milca Rosa-Velazquez, In-Cheol Cho, Alejandro E Relling, Seongsoo Hwang, Kichoon Lee

The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision

Jiayin Gao, Jiawei Wang, Shiyu Liu, Jinzhu Song, Chuanxin Zhang, Boyang Liu, Keliang Wu

The evolutionary ancient MEIS transcription factors actuate lineage-specific transcription to establish cardiac fate

Zoulfia Darieva, Peyman Zarrineh, Naomi Phillips, Joshua Mallen, Araceli Garcia Mora, Ian Donaldson, Laure Bridoux, Megan Douglas, Sara F Dias Henriques, Dorothea Schulte, Matthew J Birket, Nicoletta Bobola

Systematic identification of Y-chromosome gene functions in mouse spermatogenesis

Jeremie Subrini, Wazeer Varsally, Irina Balaguer Balsells, Maike Bensberg, Georgios Sioutas, Obah Ojarikre, Valdone Maciulyte, Björn Gylemo, Katharine Crawley, Katherine Courtis, Dirk G. de Rooij, James M. A. Turner

Transcriptional, developmental, and functional parallels of lymphatic and venous smooth muscle

Guillermo Arroyo-Ataz, Alejandra Carrasco Yagüe, Julia C. Breda, Sarah A. Mazzilli, Dennis Jones

Temporal Transcriptomic Profiling of the Developing Xenopus laevis Eye

Samantha J. Hack, Juli Petereit, Kelly Ai-Sun Tseng

CTCF-DEPENDENT INSULATION OF Hoxb13 AND THE HETEROCHRONIC CONTROL OF TAIL LENGTH

Lucille Lopez-Delisle, Jozsef Zakany, Célia Bochaton, Pierre Osteil, Alexandre Mayran, Fabrice Darbellay, Bénédicte Mascrez, Hocine Rekaik, Denis Duboule

The transcriptional landscape of the developing chick trigeminal ganglion

Carrie E. Leonard, Alec McIntosh, Lisa A. Taneyhill

Negative selection allows human primary fibroblasts to tolerate high somatic mutation loads induced by N-ethyl-N-nitrosourea

Johanna Heid, Ronald Cutler, Shixiang Sun, Moonsook Lee, Alexander Y. Maslov, Xiao Dong, Simone Sidoli, Jan Vijg

Destabilisation of bam transcripts terminates the mitotic phase of Drosophila female germline differentiation

Tamsin J Samuels, Elizabeth J Torley, Emily L Naden, Phoebe E Blair, Frankjel A Hernandez Frometa, Felipe Karam Teixeira

The metaplastic precursor state to oesophageal adenocarcinoma represents reversion to a transient epithelial cell state in the developing oesophagus

Syed Baker, Aoibheann Mullan, Rachel Jennings, Karen Piper Hanley, Yeng Ang, Claire Palles, Neil Hanley, Andrew Sharrocks

Reconstitution of chromatin reorganization during mammalian oocyte development

Jing Wang, Wang Li, Jing Guo, Xiaoming Xu, Ge Lin, Bin Li, Chun So

Vestigial like 4 regulates the adipogenesis of classical brown adipose tissue

Pingzhu Zhou, Chase W. Kessinger, Fei Gu, Amanda Davenport, Justin S. King, Genyu Wang, Steven G. Negron, Bart Deplancke, William T. Pu, Zhiqiang Lin

Zebrafish Foxl2l functions in proliferating germ cells for female meiotic entry

Ching-Hsin Yang, Yan-Wei Wang, Chen-wei Hsu, You-Jiun Pan, Bon-chu Chung

Mechanistic origin and preimplantation development of uniparental and polyploid blastomeres

Yan Zhao, Andrea Fernández-Montoro, Greet Peeters, Tatjana Jatsenko, Tine De Coster, Daniel Angel-Velez, Thomas Lefevre, Thierry Voet, Olga Tšuiko, Ants Kurg, Katrien Smits, Ann Van Soom, Joris Robert Vermeesch

Ciliary biology intersects autism and congenital heart disease

Nia Teerikorpi, Micaela C Lasser, Sheng Wang, Elina Kostyanovskaya, Ethel Bader, Nawei Sun, Jeanselle Dea, Tomasz J. Nowakowski, A Jeremy Willsey, Helen Willsey

| Stem cells, regeneration & disease modelling

Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and Transwells

Renée Moerkens, Joram Mooiweer, Eline Smits, Marijn Berg, Aarón D. Ramírez-Sánchez, Rutger Modderman, Jens Puschhof, Cayetano Pleguezuelos-Manzano, Robert J. Barrett, Cisca Wijmenga, Iris H. Jonkers, Sebo Withoff

Prenylation controls proliferation in human pluripotent stem cell-derived cardiomyocytes

Christopher A.P. Batho, Janice D. Reid, Harley R. Robinson, Henrietta Cserne Szappanos, Lynn A.C. Devilée, Sharon M. Hoyte, Rebecca L. Johnston, Rebekah Ziegman, Sarah Hassan, Lior Soday, Rebecca L. Fitzsimmons, Simon R. Foster, Dominic C. H. Ng, Edward Tate, Enzo R. Porrello, Benjamin L. Parker, Richard J. Mills, James E. Hudson

Stepwise developmental mimicry generates proximal-biased kidney organoids

Jack Schnell, Zhen Miao, MaryAnne Achieng, Connor C. Fausto, Victoria Wang, Faith De Kuyper, Matthew E. Thornton, Brendan Grubbs, Junhyong Kim, Nils O. Lindström

Characterization of Multicellular Niches Supporting Hematopoietic Stem Cells Within Distinct Zones

Ruochen Dong, Hua Li, Xi C He, Chen Wang, Anoja Perera, Seth Malloy, Jonathon Russell, Wenting Li, Kaitlyn Petentler, Xinjian Mao, Zhe Yang, Michael Epp, Kate Hall, Allison Scott, Sarah E Smith, Mark Hembree, Yongfu Wang, Sean McKinney, Jeff Haug, Jay Unruh, Brian Slaughter, Xunlei Kang, Linheng Li

De novo cancer mutations frequently associate with recurrent chromosomal abnormalities during long-term human pluripotent stem cell culture

Diana Al Delbany, Manjusha S Ghosh, Nusa Krivec, Anfien Huygebaert, Marius Regin, Chi Mai Duong, Yingnan Lei, Karen Sermon, Catharina Olsen, Claudia Spits

Specialized signaling centers direct cell fate and spatial organization in a limb organoid model

Evangelia Skoufa, Jixing Zhong, Oliver Kahre, Kelly Hu, Georgios Tsissios, Louise Carrau, Antonio Herrera, Albert Dominguez Mantes, Alejandro Castilla-Ibeas, Hwanseok Jang, Martin Weigert, Gioele La Manno, Matthias Lutolf, Marian Ros, Can Aztekin

Self-Organization of Sinusoidal Vessels in Pluripotent Stem Cell-derived Human Liver Bud Organoids

Norikazu Saiki, Yasunori Nio, Yosuke Yoneyama, Shuntaro Kawamura, Kentaro Iwasawa, Eri Kawakami, Kohei Araki, Junko Fukumura, Tsuyoshi Sakairi, Tamaki Kono, Rio Ohmura, Masaru Koido, Masaaki Funata, Wendy L. Thompson, Pamela Cruz-Encarnacion, Ya-Wen Chen, Takanori Takebe

Regeneration recapitulates many embryonic processes, including reuse of developmental regulatory regions

Kaitlyn Loubet-Senear, Mansi Srivastava

YAP1 Contributes to The Development of Contractile Force and Sarcomere Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes

Vladimir Vinarsky, Stefania Pagliari, Fabiana Martino, Cristina Mazzotti, Katerina Jirakova, Zuzana Garlikova, Enrico Di Iuri, Daniel Kytyr, Patrizia Benzoni, Martina Arici, Alessia Metallo, Kira Zeevaert, Andrea Barbuti, Wolfgang Wagner, Marcella Rocchetti, Giancarlo Forte

Molecular profile, source and lineage restriction of stem cells in an annelid regeneration model

Alexander W. Stockinger, Leonie Adelmann, Martin Fahrenberger, Christine Ruta, B. Duygu Özpolat, Guillaume Balavoine, Florian Raible

Hemogenic endothelium of the vitelline and umbilical arteries is the major contributor to mouse fetal lympho-myelopoiesis

Cristiana Barone, Giulia Quattrini, Roberto Orsenigo, Filipa Timóteo-Ferreira, Alessandro Muratore, Anna Cazzola, Arianna Patelli, Francisca Soares-da-Silva, Matthew Nicholls, Mario Mauri, Silvia Bombelli, Sofia De Marco, Deborah D’Aliberti, Silvia Spinelli, Veronica Bonalume, Alison Domingues, Gianluca Sala, Arianna Colonna, Elisabetta D’Errico, Cristina D’Orlando, Cristina Bianchi, Roberto A. Perego, Raffaella Meneveri, Marella F.T.R. De Bruijn, Ana Cumano, Alessandro Fantin, Silvia Brunelli, Rocco Piazza, Emanuele Azzoni

Characterization of Multicellular Niches Supporting Hematopoietic Stem Cells Within Distinct Zones

Ruochen Dong, Hua Li, Xi C He, Chen Wang, Anoja Perera, Seth Malloy, Jonathon Russell, Wenting Li, Kaitlyn Petentler, Xinjian Mao, Zhe Yang, Michael Epp, Kate Hall, Allison Scott, Mary C McKinney, Shengping Huang, Sarah Smith, Mark Hembree, Yongfu Wang, Zulin Yu, Jeffery Haug, Jay Unruh, Brian Slaughter, Xunlei Kang, Linheng Li

HIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos

Estefania Sanchez-Vasquez, Marianne E. Bronner, Magdalena Zernicka-Goetz

The role of polycystic kidney disease-like homologs in planarian nervous system regeneration and function

Kelly G. Ross, Sarai Alvarez Zepeda, Mohammad A. Auwal, Audrey K. Garces, Sydney Roman, Ricardo M. Zayas

Modelling genetic risk of β-cell dysfunction in human induced pluripotent stem cells from patients carrying the MTNR1B risk variant

T. Sing, S. Kalamajski, J.P.M.C.M. Cunha, S. Hladkou, F. Roberts, S. Gheibi, A. Soltanian, K. Yektay Farahmand, O. Ekström, A. Mamidi, P.W. Franks, A. Rosengren, H. Semb, H. Mulder, M. Fex

Integrating in silico predictions with an engineered tissue assay identifies Perlecan as an age-perturbed re-quiescence cue for muscle stem cells

Erik Jacques, Pauline Garcia, Orane Mercier, Yechen Hu, Cyril Degletagne, Jade Ravent, Sidy Fall, Maira P. Almeida, Aaron R. Wheeler, Stephane Angers, Penney M. Gilbert, Fabien Le Grand

Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injury

Tony Marchand, Kemi E. Akinnola, Shoichiro Takeishi, Maria Maryanovich, Sandra Pinho, Julien Saint-Vanne, Alexander Birbrair, Thierry Lamy, Karin Tarte, Paul S. Frenette, Kira Gritsman

Generation of High-fidelity Blastocyst-like Structures from Porcine Expanded Pluripotent stem cell via Chemically inducing cell plasticity

Yulei Wei, Zheng Liao, Xin Qi, Shiqiang Zhang, Xuguang Du, Shijie Yuan

Postnatal xanthine metabolism regulates cardiac regeneration in mammals

Yuichi Saito, Yuki Sugiura, Akane Sakaguchi, Tai Sada, Chihiro Nishiyama, Rae Maeda, Mari Kaneko, Hiroshi Kiyonari, Wataru Kimura

Regeneration following tissue necrosis is mediated by non-apoptotic caspase activity

Jacob W. Klemm, Chloe Van Hazel, Robin E. Harris

Modelling genetic risk of β-cell dysfunction in human induced pluripotent stem cells from patients carrying the MTNR1B risk variant

T. Singh, S. Kalamajski, J.P.M.C.M. Cunha, S. Hladkou, F. Roberts, S. Gheibi, A. Soltanian, K. Yektay Farahmand, O. Ekström, A. Mamidi, P.W. Franks, A. Rosengren, H. Semb, H. Mulder, M. Fex

Limitations in mitochondrial programming restrain the differentiation and maturation of human stem cell-derived β cells

Anne C. Lietzke, Elizabeth Bealer, Kelly Crumley, Jessica King, Ava M. Stendahl, Jie Zhu, Gemma L. Pearson, Elena Levi-D’Ancona, Belle Henry-Kanarek, Emma C. Reck, Manikanta Arnipalli, Vaibhav Sidarala, Emily M. Walker, Subramaniam Pennathur, Jesper G.S. Madsen, Lonnie D. Shea, Scott A. Soleimanpour

Axis reset is rate limiting for onset of whole-body regenerative abilities during planarian development

Clare L.T. Booth, Brian C. Stevens, Clover A. Stubbert, Neil T. Kallgren, Erin L. Davies

| Plant development

Temporally resolved growth patterns reveal novel information about the polygenic nature of complex quantitative traits

Dorothy D. Sweet, Sara B. Tirado, Julian Cooper, Nathan M. Springer, Cory D. Hirsch, Candice N. Hirsch

A spatially resolved multiomic single-cell atlas of soybean development

Xuan Zhang, Ziliang Luo, Alexandre P. Marand, Haidong Yan, Hosung Jang, Sohyun Bang, John P. Mendieta, Mark A.A. Minow, Robert J. Schmitz

LEAFY and WAPO1 jointly regulate spikelet number per spike and floret development in wheat

Francine Paraiso, Huiqiong Lin, Chengxia Li, Daniel P. Woods, Tianyu Lan, German F Burguener, Connor Tumelty, Juan M Debernardi, Anna Joe, Jorge Dubcovsky

Autoregulation of cluster root and nodule development by white lupin CCR1 receptor-like kinase

Laurence Marquès, Fanchon Divol, Alexandra Boultif, Fanny Garcia, Alexandre Soriano, Cléa Maurines-Carboneill, Virginia Fernandez, Inge Verstraeten, Hélène Pidon, Esther Izquierdo, Bárbara Hufnagel, Benjamin Péret

Phosphorylation-Dependent Activation of the bHLH Transcription Factor ICE1/SCRM Promotes Polarization of the Arabidopsis Zygote

Houming Chen, Feng Xiong, Torren Bischoff, Kai Wang, Yingjing Miao, Daniel Slane, Rebecca Schwab, Thomas Laux, Martin Bayer

The single-berry metabolomic clock paradigm reveals new stages and metabolic switches during grapevine berry development

Flora Tavernier, Stefania Savoi, Laurent Torregrosa, Philippe Hugueney, Raymonde Baltenweck, Vincent Segura, Charles Romieu

Reproducibly oriented cell divisions pattern the first flat body structures to set up dorsoventrality and de novo meristem formation in Marchantia polymorpha

Eva-Sophie Wallner, Liam Dolan

Strawberry COP9 signalosome FvCSN5 regulates plant development and fruit ripening by facilitating polyamine oxidase FvPAO5 degradation to control polyamine and H2O2 homeostasis

Yun Huang, Jiahui Gao, Qinghua Wang, Guiming Ji, Wenjing Li, Yuanyue Shen, Jiaxuan Guo, Fan Gao

A moderate water deficit induces profound changes in the proteome of developing maize ovaries

Thierry Balliau, Mariamawit Ashenafi, Melisande Blein-Nicolas, Olivier Turc, Michel Zivy, Elodie MARCHADIER

A novel repressor-activator-competitor module comprising C2H2 zinc finger and NAC transcription factors regulates rice grain development

Priya Jaiswal, Richa Priyadarshini, Antima Yadav, Aswathi P V, Arunima Mahto, Iny Mathew, Upasana Das, Falah Qasim, Ankur Vichitra, Akanksha Panwar, Ankit Verma, Akhilesh Kumar Tyagi, Pinky Agarwal

The dynamic and diverse nature of parenchyma cells in the Arabidopsis root during secondary growth

Munan Lyu, Hiroyuki Iida, Thomas Eekhout, Meeri Mäkelä, Sampo Muranen, Lingling Ye, Anne Vatén, Brecht Wybouw, Xin Wang, Bert De Rybel, Ari Pekka Mähönen

MONOPTEROS isoform MP11ir role during somatic embryogenesis in Arabidopsis thaliana

Barbara Wójcikowska, Samia Belaidi, Victoria Mironova, Helene Robert Boisivon

Dynamic regulation of H2A.Zub and H3K27me3 by ambient temperature in plant cell fate determination

Kehui Zhu, Long Zhao, Fangfang Lu, Xuelei Lin, Chongsheng He, Doris Wagner, Jun Xiao

Unraveling the in planta growth of the plant pathogen Ralstonia pseudosolanacearum by mathematical modeling

Caroline Baroukh, Léo Gerlin, Antoine Escourrou, Stéphane Genin

Early morphogenetic patterns of protonemata and gametophores of Physcomitrium patens (Hedw.) Mitt.

Manjarabad V.S. Raju, Neil W Ashton

Rapid evolution of gene expression patterns in flowering plants

Christoph Schuster, Alexander Gabel, Hajk-Georg Drost, Ivo Grosse, Ottoline Leyser, Elliot M. Meyerowitz

A common pathway controls cell size in the sepal and leaf epidermis leading to a non-random pattern of giant cells

Frances K. Clark, Gauthier Weissbart, Xihang Wang, Kate Harline, Chun-Biu Li, Pau Formosa-Jordan, Adrienne H. K. Roeder

Chemical genetics reveals cross-activation of plant developmental signaling by the immune peptide-receptor pathway

Arvid Herrmann, Krishna Mohan Sepuru, Hitoshi Endo, Ayami Nakagawa, Shuhei Kusano, Pengfei Bai, Asraa Ziadi, Hiroe Kato, Ayato Sato, Jun Liu, Libo Shan, Seisuke Kimura, Kenichiro Itami, Naoyuki Uchida, Shinya Hagihara, Keiko U. Torii

Time-resolved tracking of cellulose biosynthesis and microfibril network assembly during cell wall regeneration in live Arabidopsis protoplasts

Hyun Huh, Dharanidaran Jayachandran, Junhong Sun, Mohammad Irfan, Eric Lam, Shishir P. S. Chundawat, Sang-Hyuk Lee

Water availability determines plant regeneration fates

Abdul Kareem, Anna K. van Wüllen, Ai Zhang, Gabriel Walckiers, Ellen Fasth, Charles W. Melnyk

| Evo-devo

The sensory shark: high-quality morphological, genomic and transcriptomic data for the small-spotted catshark Scyliorhinus canicula reveal the molecular bases of sensory organ evolution in jawed vertebrates

H. Mayeur, J. Leyhr, J. Mulley, N. Leurs, L. Michel, K. Sharma, R. Lagadec, J.-M. Aury, O.G. Osborne, P. Mulhair, J. Poulain, S. Mangenot, D. Mead, M. Smith, C. Corton, K. Oliver, J. Skelton, E. Betteridge, J. Dolucan, O. Dudchenko, A.D. Omer, D. Weisz, E.L. Aiden, S. McCarthy, Y. Sims, J. Torrance, A. Tracey, K. Howe, T Baril, A. Hayward, C. Martinand-Mari, S. Sanchez, T. Haitina, K. Martin, S.I. Korsching, S. Mazan, M. Debiais-Thibaud

Bird brains fit the bill: morphological diversification and the evolution of avian brain size

Zitan Song, Szymon M Drobniak, Yang Liu, Carel P van Schaik, Michael Griesser

Dynamics of X chromosome hyper-expression and inactivation in male tissues during stick insect development

Jelisaveta Djordjevic, Patrick Tran Van, William Toubiana, Marjorie Labédan, Zoé Dumas, Jean-Marc Aury, Corinne Cruaud, Benjamin Istace, Karine Labadie, Benjamin Noel, Darren J Parker, Tanja Schwander

Unravelling a diversity of cellular structures and aggregation dynamics during the early development of Myxococcus xanthus

Natsuko Rivera-Yoshida, Alejandro V. Arzola, Mariana Benitez

Induction of ectopic external gills and tetrapodomorph-like skeletal elements through homeotic transformations in the salamander branchial region

Jan Vintr, Vladimír Soukup

The functional roles of zebrafish HoxA- and HoxD-related clusters in the pectoral fin development

Mizuki Ishizaka, Hidemichi Nakazawa, Akiteru Maeno, Haruna Kanno, Renka Fujii, Taisei Tani, Sae Oikawa, Rina Koita, Akionori Kawamura

Characterization of eight new Hydractinia i-cell markers reveals underlying heterogeneity in the adult pluripotent stem cell population

Justin Waletich, Danielle de Jong, Christine E. Schnitzler

A fast and robust gene knockout method for Salpingoeca rosetta clarifies the genetics of choanoflagellate multicellular development

Chantal Combredet, Thibaut Brunet

Elevational constraints on flight efficiency shape global gradients in avian wing morphology

Jingyi Yang, Chenyue Yang, Hung-wei Lin, Alexander C. Lees, Joseph A. Tobias

The rich evolutionary history of the ROS metabolic arsenal shapes its mechanistic plasticity at the onset of metazoan regeneration

Aurore Vullien, Aldine Amiel, Loeiza Baduel, Dilara Diken, Cecile Renaud, Michel Vervoort, Eric Rottinger, Eve Gazave

CO-OPTION OF NECK MUSCLES SUPPORTED THE VERTEBRATE WATER-TO-LAND TRANSITION

Eglantine Heude, Hugo Dutel, Frida Sanchez-Garrido, Karin D. Prummel, Robert Lalonde, France Lam, Christian Mosimann, Anthony Herrel, Shahragim Tajbakhsh

Ridge and crossrib height of butterfly wing scales is a toolbox for structural color diversity

Cédric Finet, Qifeng Ruan, Yi Yang Bei, Vinodkumar Saranathan, Antónia Monteiro

Embryological insights into the evolution of genome regulation using haploid and diploid whiteflies, Bemisia tabaci

Emily A. Shelby, Elizabeth C. McKinney, Alvin M. Simmons, Allen J. Moore, Patricia J. Moore

The evolutionary modifications of a GoLoco motif in the AGS protein facilitate micromere formation in the sea urchin embryo

Natsuko Emura, Florence D.M. Wavreil, Annaliese Fries, Mamiko Yajima

Cell Biology

Muskelin acts as a substrate receptor of the highly regulated Drosophila CTLH E3 ligase during the maternal-to-zygotic transition

Chloe A. Briney, Jesslyn C. Henriksen, Chenwei Lin, Lisa A. Jones, Leif Benner, Addison B. Rains, Roxana Gutierrez, Philip R. Gafken, Olivia S. Rissland

Reorganization of the Flagellum Scaffolding Induces a Sperm Standstill During Fertilization

Martina Jabloñski, Guillermina M. Luque, Matías D. Gómez-Elías, Claudia Sanchez-Cardenas, Xinran Xu, Jose Luis de la Vega-Beltran, Gabriel Corkidi, Alejandro Linares, Victor X. Abonza Amaro, Aquetzalli Arenas-Hernandez, María Del Pilar Ramos-Godinez, Alejandro López-Saavedra, Dario Krapf, Diego Krapf, Alberto Darszon, Adan Guerrero, Mariano G. Buffone

Polyamines regulate cell fate by altering the activity of histone-modifying enzymes

Maya Emmons-Bell, Grace Forsyth, Abby Sundquist, Sylvie Oldeman, Angeliki Gardikioti, Roshni de Souza, Jonathan Coene, Maryam H. Kamel, Shine Ayyapan, Harrison A. Fuchs, Steven Verhelst, Joanna Smeeton, Catherine A. Musselman, Juan-Manuel Schvartzman

Oviductin sets the species-specificity of the mammalian zona pellucida

Daniel de la Fuente, Maria Maroto, Yulia N Cajas, Karina Cañón-Beltrán, Raul Fernandez-Gonzalez, Ana Munoz-Maceda, Juana M Sanchez-Puig, Rafael Blasco, Paula Cots, Manuel Aviles, Dimitrios Rizos, Alfonso Gutiérrez-Adán

The ERK5 MAP kinase regulates annexin complexes and membrane dynamics in embryonic stem cells

Helen A. Brown, Ludivine Guillet, Charles A. C. Williams, Hayley Shaw, Houjiang Zhou, Diana Rios-Szwed, Rosalia Fernandez-Alonso, Liam McMulkin, Marios P. Stavridis, Greg M. Findlay

Placental malaria is associated with a TLR–Endothelin-3–oxidative damage response in human placenta tissues

Samuel Chenge, Melvin Mbalitsi, Harrison Ngure, Moses Obimbo, Mercy Singoei, Mourine Kangogo, Bernard N. Kanoi, Jesse Gitaka, Francis M. Kobia

Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila

Pengzhen Dong, Yue Li, Yuying Wang, Qiang Zhao, Tianfeng Lu, Tianyu Guo, Jun Ma, Bing Yang, Honggang Wu, Hai Huang

The role of ER exit sites in maintaining P-body organization and transmitting ER stress response during Drosophila melanogaster oogenesis

Samantha N. Milano, Livia V. Bayer, Julie J. Ko, Caroline E. Casella, Diana P. Bratu

H3.3 deposition counteracts the replication-dependent enrichment of H3.1 at chromocenters in embryonic stem cells

Stefano Arfe, Tina Karagyozova, Audrey Forest, Hatem Hmidan, Eran Meshorer, Jean-Pierre Quivy, Genevieve Almouzni

KIF2A maintains cytokinesis in mouse embryonic stem cells by stabilising intercellular bridge microtubules

Lieke Stockmann, Hélène Kabbech, Gert-Jan Kremers, Brent van Herk, Bas Dille, Mirjam van den Hout, Wilfred F.J. van IJcken, Dick Dekkers, Jeroen A.A. Demmers, Ihor Smal, Danny Huylebroeck, Sreya Basu, Niels Galjart

Defining a Muscle Stem Cell matrisome signature: from transcriptome data to extracellular matrix niche topology

Emilie Guillon, Bacar Hisoilat, Takako Sasaki, Philippos Mourikis, Florence Ruggiero

The initiation and early development of apical-basal polarity in Toxoplasma gondii

Luisa F. Arias Padilla, Jonathan Munera Lopez, Aika Shibata, John M. Murray, Ke Hu

Local nuclear to cytoplasmic ratio regulates chaperone-dependent H3 variant incorporation during zygotic genome activation

Anusha D Bhatt, Madeleine G Brown, Aurora B Wackford, Yuki Shindo, Amanda A Amodeo

Control of lumen geometry and topology by the interplay between pressure and cell proliferation rate in pancreatic organoids

Byung Ho Lee, Kana Fuji, Heike Petzold, Phil Seymour, Siham Yennek, Coline Schewin, Allison Lewis, Daniel Riveline, Tetsuya Hiraiwa, Masaki Sano, Anne Grapin-Botton

Claudin-11 regulates immunological barrier formation and spermatogonial proliferation through stem cell factor

Taichi Sugawara, Kayoko Sonoda, Nattapran Chompusri, Kazuhiro Noguchi, Seiji Okada, Mikio Furuse, Tomohiko Wakayama

Sub-chronic elevation in ambient temperature drives alterations to the sperm epigenome and accelerates early embryonic development in mice

Natalie A. Trigg, John E. Schjenken, Jacinta H. Martin, David A. Skerrett-Byrne, Shannon P. Smyth, Ilana R. Bernstein, Amanda L. Anderson, Simone J. Stanger, Ewan N.A. Simpson, Archana Tomar, Raffaele Teperino, Colin C. Conine, Geoffry N. De Iuliis, Shaun D. Roman, Elizabeth G. Bromfield, Matthew D. Dun, Andrew L. Eamens, Brett Nixon

Inseparable/IER3IP1 are essential for cytokinesis in Drosophila neuroblast and human cells

Aishwarya Kakade, Sachin Gupta, Reshmi Verghese, Harikrishna Adicherla, Sonal Nagarkar-Jaiswal

Localization of Drosophila formin, Cappuccino, influences posterior oocyte organization

Hannah M. Bailey, Peter B. M. Cullimore, Liam A. Bailey, Margot E. Quinlan

PLK-1 regulates MEX-1 polarization in the C. elegans zygote

Amelia J. Kim, Stephanie I. Miller, Elora C. Greiner, Arminja N. Kettenbach, Erik E. Griffin

MitoNEET reduces the mitochondrial oxidative phosphorylation during epithelial-mesenchymal transition

Haruka Handa, Yasuhito Onodera, Tsukasa Oikawa, Shingo Takada, Koji Ueda, Daiki Setoyama, Takashi Yokota, Miwako Yamasaki, Masahiko Watanabe, Yoshizuki Fumoto, Ari Hashimoto, Soichiro Hata, Masaaki Murakami, Hisataka Sabe

Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification

Adiyant Lamba, Meng Zhu, Maciej Meglicki, Sylwia Czukiewska, Lakshmi Balasubramaniam, Ron Hadas, Nina Weishaupt, Ekta M. Patel, Yu Hua Kavanagh, Ran Wang, Naihe Jing, Magdalena Zernicka-Goetz

Nuclear Argonaute protein NRDE-3 switches small RNA binding partners during embryogenesis coincident with the formation of SIMR granules

Shihui Chen, Carolyn M. Phillips

Modelling

Dynamics of positional information in the vertebrate neural tube

Anđela Marković, James Briscoe, Karen M Page

Control of Modular Tissue Flows Shaping the Embryo in Avian Gastrulation

Guillermo Serrano Nájera, Alex M Plum, Benjamin Steventon, Cornelis J Weijer, Mattia Serra

Physical modeling of embryonic transcriptomes identifies collective modes of gene expression

Dominic J. Skinner, Patrick Lemaire, Madhav Mani

Emergence of cellular nematic order is a conserved feature of gastrulation in animal embryos

Xin Li, Robert J. Huebner, Margot L.K. Williams, Jessica Sawyer, Mark Peifer, John B. Wallingford, D. Thirumalai

Comparing AI versus Optimization Workflows for Simulation-Based Inference of Spatial-Stochastic Systems

Michael A. Ramirez-Sierra, Thomas R. Sokolowski

Engineering morphogenesis of cell clusters with differentiable programming

Ramya Deshpande, Francesco Mottes, Ariana-Dalia Vlad, Michael P. Brenner, Alma dal Co

Neurodevelopmental disorders modeling using isogeometric analysis, dynamic domain expansion and local refinement

Kuanren Qian, Genesis Omana Suarez, Toshihiko Nambara, Takahisa Kanekiyo, Ashlee S. Liao, Victoria A. Webster-Wood, Yongjie Jessica Zhang

Data-driven quasiconformal morphodynamic flows

Salem Mosleh, Gary P. T. Choi, L. Mahadevan

A general mathematical framework for understanding the behavior of heterogeneous stem cell regeneration

Jinzhi Lei

Tools & Resources

Scalable Hypothalamic Arcuate Neuron Differentiation from Human Pluripotent Stem Cells Suitable for Modeling Metabolic and Reproductive Disorders

Vukasin M. Jovanovic, Narisu Narisu, Lori L. Bonnycastle, Ravi Tharakan, Kendall T. Mesch, Hannah J. Glover, Tingfen Yan, Neelam Sinha, Chaitali Sen, David Castellano, Shu Yang, Dvir Blivis, Seungmi Ryu, Daniel F. Bennett, Giovanni Rosales-Soto, Jason Inman, Pinar Ormanoglu, Christopher A. LeClair, Menghang Xia, Martin Schneider, Erick O. Hernandez-Ochoa, Michael R. Erdos, Anton Simeonov, Shuibing Chen, Ilyas Singeç, Francis S. Collins, Claudia A. Doege, Carlos A. Tristan

Design, infectability, and transcriptomic analysis of transregionally differentiated and scalable lung organoids derived from adult bronchial cells

Alicia Reyes Valenzuela, Mark Turner, Nathan Markarian, Christophe Lachance-Brais, John Hanrahan, Hojatollah Vali, Silvia Vidal, Luc Mongeau

Comparative analysis of the syncytiotrophoblast in placenta tissue and trophoblast organoids using snRNA sequencing

Madeline M Keenen, Liheng Yang, Huan Liang, Veronica J Farmer, Rohit Singh, Amy S Gladfelter, Carolyn B Coyne

Mapping the human hematopoietic stem and progenitor cell hierarchy through integrated single-cell proteomics and transcriptomics

Benjamin Furtwängler, Nil Üresin, Sabrina Richter, Mikkel Bruhn Schuster, Despoina Barmpouri, Henrietta Holze, Anne Wenzel, Kirsten Grønbæk, Kim Theilgaard-Mönch, Fabian J. Theis, Erwin M. Schoof, Bo T Porse

A multiomic atlas of human early skeletal development

Ken To, Lijiang Fei, Jan Patrick Pett, Kenny Roberts, Krzysztof Polański, Tong Li, Nadav Yayon, Peng He, Chuan Xu, James Cranley, Ruoyan Li, Kazumasa Kanemaru, Ni Huang, Stathis Megas, Laura Richardson, Rakesh Kapuge, Shani Perera, Elizabeth Tuck, Anna Wilbrey-Clark, Ilaria Mulas, Fani Memi, Batuhan Cakir, Alexander V. Predeus, David Horsfall, Simon Murray, Martin Prete, Pavel Mazin, Xiaoling He, Kerstin B. Meyer, Muzlifah Haniffa, Roger A. Barker, Omer Bayraktar, Christopher D. Buckley, Sarah A. Teichmann

Temporally resolved single cell transcriptomics in a human model of amniogenesis

Nikola Sekulovski, Amber E. Carleton, Anusha A. Rengarajan, Chien-Wei Lin, Lauren N. Juga, Allison E. Whorton, Jenna K. Schmidt, Thaddeus G. Golos, Kenichiro Taniguchi

Inclusive, Exclusive and Hierarchical Atlas of NFATc1+/PDGFR-α+ Cells in Dental and Periodontal Mesenchyme

Xue Yang, Chuyi Han, Changhao Yu, Bin Zhou, Ling Ye, Feifei Li, Fanyuan Yu

Three-dimensional culture in a bioengineered matrix and somatic cell complementation to improve growth and survival of bovine preantral follicles

Juliana I. Candelaria, Ramon C. Botigelli, Carly Guiltinan, Ariella Shikanov, Anna C. Denicol

Single-cell transcriptomic profiling of the whole colony of Botrylloides diegensis: Insights into tissue specialization and blastogenesis

Berivan Temiz, Michael Meier, Megan J Wilson

Characterisation of human hair follicle development

Zoe R. Sudderick, James D. Glover, Cameron Batho-Samblas, Barbara Bo-Ju Shih, Denis J. Headon

Creation of a novel zebrafish model with low DHA status to study the role of maternal nutrition during neurodevelopment

Katherine M. Ranard, Bruce Appel

Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

Leonid Peshkin, Enrico Maria Daldello, Elizabeth S Van Itallie, Matthew Sonnett, Johannes Kreuzer, Wilhelm Haas, Marc W Kirschner, Catherine Jessus

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