the community site for and by developmental biologists
the community site for and by developmental biologists
Posted by the Node Interviews on August 13th, 2019
This interview, the 67th in our series, was recently published in Development Most bones in the vertebrate skeleton are made in the same way – endochondrial ossification – yet they display a variety of shapes and sizes. The question of how these unique bone morphologies, including the superstructures that protrude from their surfaces, arise during development is[…]
Posted by the Node Interviews on July 9th, 2019
This interview, the 66th in our series, was recently published in Development Transcriptional autoregulation occurs when transcription factors bind their own cis-regulatory sequences, ensuring their own continuous expression along with expression of other targets. During development, continued expression of identity-specifying transcription factors can be achieved by autoregulation, but until now formal evidence for a developmental requirement of autoregulation[…]
Posted by the Node Interviews on June 24th, 2019
This interview, the 65th in our series, was recently published in Development During development, mechanical forces sculpt tissues into myriad forms. Actomyosin contractility generated within the cell has an increasingly appreciated role in this process, but how tissue forces relate to the physical properties of the extracellular matrix is still poorly understood, particularly at longer time scales[…]
Posted by the Node Interviews on June 19th, 2019
This interview, the 64th in our series, was recently published in Development One of the most obvious examples of left-right asymmetry in animal bodies comes from snails: in most species or strains, the shells coil dextrally, but some coil sinistrally. The control of coiling is genetic and begins in the early embryo. Previous work has implicated the[…]
Posted by the Node Interviews on May 28th, 2019
This interview, the 63rd in our series, was recently published in Development Butterfly eyespots are striking examples of animal patterning, but their developmental origins are still relatively poorly understood. A new paper in Development– the result of a collaboration between two Singapore-based labs – now combines CRISPR-Cas9 gene targeting with theoretical modelling to address the role of the[…]
Posted by the Node Interviews on May 23rd, 2019
This interview, the 62nd in our series, was recently published in Development Vascular development critically involves pruning, which helps to remodel an immature network containing excess microvessels into a mature and functioning one. The mechanisms of vascular remodelling and the relationship between the endothelial cells and the other cell types with which they are closely associated are,[…]
Posted by the Node Interviews on May 9th, 2019
This interview, the 61st in our series, was recently published in Development A fundamental aim in developmental biology is to understand how the various cell types of the body are specified by differential gene regulation. Caenorhabditiselegans nervous system development provides a powerful system for studying this, as exemplified by a new Development paper reporting on how the BAG neurons that help[…]
Posted by the Node Interviews on April 18th, 2019
This interview, the 60th in our series, was recently published in Development In development and during regeneration in adults, muscle fibres develop from muscle progenitor cells, and the proliferation, differentiation and fusion of these progenitors needs to be tightly controlled and co-ordinated. A new paper in Development studies the role of the mTOR protein in this process using genetic[…]
Posted by katarney on March 20th, 2019
In this episode of Genetics Unzipped we have a very special interview with leading geneticist Mary-Claire King.
Posted by the Node Interviews on March 13th, 2019
This interview, the 59th in our series, was recently published in Development The control of timing in development is crucial, both within and between tissues. Heterochrony involves shifts in the rate of development of some tissues relative to others, and although the first heterochronic genes were identified in Caenorhabditis elegans in the early 1980s, their role in inter-tissue developmental[…]
