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Course announcement: Gene Regulatory Networks for Development

Posted by , on 6 July 2023

After a pandemic related hiatus the MBL Gene regulatory networks (GRNs) course at Woods Hole is back. It’s been refreshed with new course directors and faculty and is better than ever. It covers experimental and computational methods used to study GRNs, through highly interactive lectures, discussions, group projects, and practical tutorials.

Course date:
Oct 08, 2023 – Oct 20, 2023

Application deadline:
July 21, 2023

To apply:

Gene regulatory networks (GRNs) are key to the genomic control of development in animals and plants. To study GRNs requires insights from various research fields, including systems biology, developmental and evolutionary biology, as well as functional genomics, and provides an integrative approach to fundamental research questions in biology. This course introduces the concepts of GRNs, and teaches experimental and computational methods used to study them, through highly interactive lectures, discussions, group projects, and practical tutorials. We will cover a broad range of topics, including transcriptional control systems, the structural organization of hierarchical networks, developmental functions of GRN circuit modules, GRN evolution, and computational modelling using BioTapestry as well as Boolean and quantitative mathematical approaches. Students will learn how to generate GRN models based on data extracted from the literature, and will generate computational models to analyze dynamic circuit behavior. We will present and discuss a broad range of experimental approaches and how they are effectively used for studying gene regulation and developmental GRNs. Examples of experimentally solved developmental GRNs from a variety of organisms, such as flies, sea urchins, frogs, chicken, and mice, will be explored. Students are encouraged to share their research projects in a poster session, and to discuss with course faculty how to apply the approaches taught in the course to their own research questions. The course is intended for advanced graduate students, postdoctoral scholars, and faculty.

Course Faculty and Lecturers
Leslie Babonis, Cornell
Sarah Tulin, Canisius College
Crystal Rogers, UC Davis
Scott Barolo, University of Muchigan
Doug Erwin, Smithsonian
Mark Rebeiz, University of Pittsburgh
William Longabaugh, Institute for Systems Biology
Paola Oliveri, University College London
Roberto Feuda, University of Leicester
Nipam Patel, Marine Biological Laboratory
Zeba Wunderlich, Boston University
Hui-Chun Lu (grace), University College London
James Briscoe, Crick Institute
Andrea Streit, King’s College London
Megan Martik, UC Berkeley

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