Today’s recommended paper is:
A system of repressor gradients spatially organizes the boundaries of Bicoid-dependent target genes.
Hongtao Chen, Zhe Xu, Constance Mei, Danyang Yu and Stephen Small (2012)
Cell 149 (3), 618-629
Submitted twice – by Andrew Renault and by Seema Grewal.
Andrew: “How morphogens create robust and discrete responses has been a long standing question. This paper nicely shows that the correct order of Bicoid target gene boundaries depends on a system of transcriptional repressors, reinforcing the notion that antagonistic mechanisms are critical for morphogen function”
Seema: “This paper challenges the idea that Bicoid acts as a simple morphogen.”
From December 1 to 24 we are featuring Node readers’ favourite papers of the past year. Click the calendar in the side bar each day to see a new paper. To see all papers submitted so far, see the calendar archive.