Today’s recommended paper is:
NuRD Suppresses Pluripotency Gene Expression to Promote Transcriptional Heterogeneity and Lineage Commitment
Nicola Reynolds et al. (2012)
Cell Stem Cell 10 (5), 583-594
Submitted by Mary Todd Bergman:
“Paul Bertone’s lab at EMBL-EBI discovered a key component of the ‘go’ signal that tells stem cells to commit already and become one type of cell or another. In collaboration with Brian Hendrich at the University of Cambridge, Paul’s group studied differences in gene expression patterns between self-renewing and differentiating stem cells, specifically focusing on the Nucleosome Remodelling and Deacetylation (NuRD) corepressor complex. They found that NuRD directly regulates how pluripotency genes are expressed in stem cells, and that NuRD is required for their exit from pluripotency. They also investigated the binding patterns of the NuRD complex to understand how it regulates its target genes. Combined with transcriptional profiling, a picture emerged of NuRD as a gatekeeper of cell differentiation.”
From December 1 to 24 we are featuring Node readers’ favourite papers of the past year. Click the calendar in the side bar each day to see a new paper. To see all papers submitted so far, see the calendar archive.