Happy New Year! Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints.

The preprints this month are hosted on bioRxiv – use these links below to get to the section you want:

Developmental biology

• Patterning & signalling
• Morphogenesis & mechanics
• Genes & genomes
• Stem cells, regeneration & disease modelling
• Plant development
• Evo-devo

Cell Biology

Modelling

Tools & Resources

Research practice and education

Developmental biology

| Patterning & signalling

Fibroblast Growth Factor-induced lens fiber cell elongation is driven by the stepwise activity of Rho and Rac

Yuki Sugiyama, Daniel A. Reed, David Herrmann, Frank J. Lovicu, Michael L. Robinson, Paul Timpson, Ichiro Masai

The CD36 scavenger receptor Bez regulates lipid redistribution from fat body to oocytes in Drosophila

Pilar Carrera, Johanna Odenthal, Katharina S. Risse, Yerin Jung, Lars Kuerschner, Margret H. Bülow

Postnatal FGF-signalling establishes gradients of cell-identities along the proximal-distal axis of the lung airways

Alexandros Sountoulidis, Alexandra Firsova, Andreas Liontos, Jonas Theelke, Janine Koepke, Pamela Millar-Büchner, Louise Mannerås-Holm, Åsa Björklund, Athanasios Fysikopoulos, Konstantin Gaengel, Fredrik Bäckhed, Christer Betsholtz, Werner Seeger, Saverio Bellusci, Christos Samakovlis

Natural reversal of cavefish heart asymmetry is controlled by Sonic Hedgehog effects on the left-right organizer

Mandy Ng, Li Ma, Janet Shi, William R. Jeffery

Sensory progenitors influence patterning of the mammalian auditory sensory epithelium.

Caryl Ann Young, Emily Burt, Vidhya Munnamalai

Live-imaging reveals Coordinated Cell Migration and Cardiac Fate Determination during Mammalian Gastrulation.

Shayma Abukar, Peter Embacher, Alessandro Cicarrelli, Sunita Varsani-Brown, Jamie A Dean, James Briscoe, kenzo Ivanovitch

Gap junction mediated bioelectric coordination is required for slow muscle development, organization, and function

RM Lukowicz-Bedford, JS Eisen, AC Miller

Metabolic control of germ layer proportions through regulation of Nodal and Wnt signalling

Kristina S. Stapornwongkul, Elisa Hahn, Laura Salamo Palau, Krisztina Arato, Nicola Gritti, Kerim Anlas, Patryk Poliński, Mireia Osuna Lopez, Miki Eibisuya, Vikas Trivedi

EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues

D. Nathaniel Clarke, Adam C. Martin

Single-cell transcriptomic profiling of the neonatal oviduct and uterus reveals new insights into upper Müllerian duct regionalization

Shuai Jia, Fei Zhao

Steroid signaling controls sex-specific development in an invertebrate

Lydia Grmai, Erin Jimenez, Ellen Baxter, Mark Van Doren

C. elegans Hedgehog-related proteins are tissue- and substructure-specific components of the cuticle and pre-cuticle

Nicholas D. Serra, Chelsea B. Darwin, Meera V. Sundaram

p75NTR neurotrophin receptor function is redundant for development, growth and fertility in the rat

Stephen Meek, Karamjit Singh-Dolt, Linda Sutherland, Matthew G.F. Sharp, Jorge Del-Pozo, David Walker, Tom Burdon

Identification of a myofibroblast differentiation program during neonatal lung development

Yongjun Yin, Jeffrey R. Koenitzer, Debabrata Patra, Sabine Dietmann, Peter Bayguinov, Andrew S. Hagan, David M. Ornitz

First cleavage is a manifestation of the geometry of the unfertilized oocyte: implications for monozygotic twinning in mice.

Thomas Nolte, Reza Halabian, Steffen Israel, Yutaka Suzuki, Georg Fuellen, Wojtek Makalowski, Michele Boiani

| Morphogenesis & mechanics

Lens Placode Modulates Extracellular Matrix Formation During Early Eye Development

Cecília G. De Magalhães, Ales Cvekl, Ruy G. Jaeger, C. Y. Irene Yan

Fetal lung vascular development is disrupted by mechanical compression and rescued by administration of amniotic fluid stem cell extracellular vesicles via regulation of the Hippo signaling pathway

Rebeca L. Figueira, Kasra Khalaj, Lina Antounians, Fabian Doktor, Maria Sole Gaffi, Mikal Obed, Sree Gandhi, Augusto Zani

Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis

Siyuan Cheng, Ivan Fan Xia, Renate Wanner, Javier Abello, Amber N. Stratman, Stefania Nicoli

Getting there in one piece: The Rac pathway prevents cell fragmentation in a nonprotrusively migrating leader cell during organogenesis

Noor Singh, Karen Jian Li, Kacy Lynn Gordon

Reduced fetal cerebral blood flow following prenatal drug exposure predicts perinatal mortality

Siara Kate Rouzer, Anirudh Sreeram, Rajesh Miranda

The molecular and cellular anatomy of a fetal programming defect – the impact of low protein diet on the developing kidney

Kieran M. Short, Giovane G. Tortelote, Lynelle K. Jones, Fabiola Diniz, Francesca Edgington-Giordano, Luise A. Cullen-McEwen, Jan Schröder, Ashley Spencer, Andrew Keniry, Jose M. Polo, John F. Bertram, Marnie E. Blewitt, Ian M. Smyth, Samir S. El-Dahr

β-H-Spectrin is a key component of an apical-medial hub of proteins during cell wedging in tube morphogenesis

Ghislain Gillard, Katja Röper

Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion

Nikaya Polsani, Theodora Yung, Evan Thomas, Melissa Phung-Rojas, Isha Gupta, Julie Denker, Xiaotian Feng, Beatriz Ibarra, Sevan Hopyan, Radhika P. Atit

Development of Pial Collaterals by Extension of Pre-existing Artery Tips

Suraj Kumar, Niloufer Shanavas, Swarnadip Ghosh, Vinayak Sivaramakrishnan, Manish Dwari, Soumyashree Das

Mechanical strengthening of cell-cell adhesion during mouse embryo compaction

Ludmilla de Plater, Julie Firmin, Jean-Léon Maître

“Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation”

Pedro Vallecillo-García, Mira Nicola Kühnlein, Mickael Orgeur, Nils Rouven Hansmeier, Georgios Kotsaris, Bernd Timmermann, Claudia Giesecke-Thiel, René Hägerling, Sigmar Stricker

Neuroepithelial depletion schedules cessation of neurogenesis in the Drosophila optic lobes

Phuong-Khanh Nguyen, Louise Y Cheng

Persistence of the primary somatosensory system in zebrafish

Joaquin Navajas Acedo

Lumen pressure modulation in chicken embryos

Susannah B.P. McLaren, Fengzhu Xiong

| Genes & genomes

CTCF-mediated 3D chromatin predetermines the gene expression program in the male germline

Yuka Kitamura, Kazuki Takahashi, So Maezawa, Yasuhisa Munakata, Akihiko Sakashita, Noam Kaplan, Satoshi H. Namekawa

Msx genes delineate a novel molecular map of the developing cerebellar neuroepithelium

Ishita Gupta, Joanna Yeung, Maryam Rahimi-Balaei, Sih-Rong Wu, Daniel Goldowitz

Paternally-induced environmental programming of placenta development, offspring birth weight and health phenotypes in a mouse model

Elaine Chen, Raquel Santana da Cruz, Aallya Nascimento, Meghali Joshi, Duane Gischewski Pereira, Odalys Dominguez, Gabriela Fernandes, Megan Smith, Sara P.C. Paiva, Sonia de Assis

Revisiting bicoid function: complete inactivation reveals an additional fundamental role in Drosophila egg geometry specification

Stefan Baumgartner

OVO Positively Regulates Essential Maternal Pathways by Binding Near the Transcriptional Start Sites in the Drosophila Female Germline

Leif Benner, Savannah Muron, Jillian G. Gomez, Brian Oliver

Early Embryonic Establishment of Constitutive Heterochromatin Involves H3K14ac-mediated Recruitment of Eggless/SetDB1

Ruijun Tang, Mengqi Zhou, Yuwei Chen, Zhenghui Jiang, Xunan Fan, Jingheng Zhang, Aiping Dong, Lu Lv, Song Mao, Fang Chen, Jinrong Min, Ke Liu, Kai Yuan

Differential gene expression underpinning production of distinct sperm morphs in the wax moth Galleria mellonella

Emma Moth, Fiona Messer, Saurabh Chaudhary, Helen White-Cooper

SRRM2 splicing factor modulates cell fate in early development

Silvia Carvalho, Luna Zea-Redondo, Tsz Ching Chloe Tang, Philipp Stachel-Braum, Duncan Miller, Paulo Caldas, Alexander Kukalev, Sebastian Diecke, Stefanie Grosswendt, Ana Rita Grosso, Ana Pombo

SMPD4 mediated sphingolipid metabolism regulates brain and primary cilia development

Katherine A. Inskeep, Bryan Crase, Rolf W. Stottmann

Stage-specific expression patterns and co-targeting relationships among miRNAs in the developing mouse cerebral cortex

Hristo Todorov, Stephan Weißbach, Laura Schlichtholz, Hanna Mueller, Dewi Hartwich, Susanne Gerber, Jennifer Winter

Anp32e protects against accumulation of H2A.Z at Sox motif containing promoters during zebrafish gastrulation

Fabian H Halblander, Fanju W Meng, Patrick J Murphy

Early transcriptional similarities between two distinct neural lineages during ascidian embryogenesis

Richard R Copley, Julia Buttin, Marie-Jeanne Arguel, Geraldine Williaume, Kevin Lebrigand, Pascal Barbry, Clare Hudson, Hitoyoshi Yasuo

Temporal transcriptomic dynamics in developing macaque neocortex

Longjiang Xu, Zan Yuan, Jiafeng Zhou, Yuan Zhao, Wei Liu, Shuaiyao Lu, Zhanlong He, Boqin Qiang, Pengcheng Shu, Yang Chen, Xiaozhong Peng

Comparative Hox genes expression within the dimorphic annelid Streblospio benedicti reveals patterning variation during development

Jose Maria Aguilar-Camacho, Nathan D. Harry, Christina Zakas

FGF8-mediated gene regulation affects regional identity in human cerebral organoids

Michele Bertacchi, Gwendoline Maharaux, Agnès Loubat, Mathieu Jung, Michèle Studer

RNA-sequencing reveals strong predominance of THRA splicing isoform 2 in the developing and adult human brain

Eugenio Graceffo, Robert Opitz, Matthias Megges, Heiko Krude, Markus Schuelke

DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility

Shuangyi Xu, Ning Wang, Michael V. Zuccaro, Jeannine Gerhardt, Timour Baslan, Amnon Koren, Dieter Egli

Expression of the transcription factor Isl1 in dopaminergic neurons of the mouse forebrain

Adriana C. Camarano, Marcelo Rubinstein, Flavio S. J. de Souza

Direct Male Development in Chromosomally ZZ Zebrafish

Catherine A. Wilson, Peter Batzel, John H. Postlethwait

Sex chromosome dominance in a UV sexual system

Jeromine Vigneau, Claudia Martinho, Olivier Godfroy, Min Zheng, Fabian B. Haas, Michael Borg, Susana M. Coelho

| Stem cells, regeneration & disease modelling

Leptomeningeal Neural Organoid (LMNO) Fusions as Models to Study Meninges-Brain Signaling

Hannah E Jones, Gabriella L Robertson, Alejandra Romero-Morales, Rebecca O’Rourke, Julie A Siegenthaler, Vivian Gama

Human naïve stem cell models reveal the role of FGF in hypoblast specification in the human embryo

Anish Dattani, Elena Corujo-Simon, Arthur Radley, Tiam Heydari, Yasaman Taheriabkenar, Francesca Carlisle, Simeng Lin, Jonathan Mill, Peter Zandstra, Jennifer Nichols, Ge Guo

The Use of a SOX10 Reporter Towards Ameliorating Oligodendrocyte Lineage Differentiation from Human Induced Pluripotent Stem Cells

Valerio E.C. Piscopo, Alexandra Chapleau, Gabriela J. Blaszczyk, Julien Sirois, Zhipeng You, Vincent Soubannier, Geneviève Bernard, Jack P. Antel, Thomas M. Durcan

Integrated Molecular-Phenotypic Profiling Reveals Metabolic Control of Morphological Variation in Stembryos

Alba Villaronga Luque, Ryan Savill, Natalia López-Anguita, Adriano Bolondi, Sumit Garai, Seher Ipek Gassaloglu, Aayush Poddar, Aydan Bulut-Karslioglu, Jesse V Veenvliet

N-Glycans on the extracellular domain of the Notch1 receptor control Jagged-1 induced Notch signalling and myogenic differentiation of S100β resident vascular stem cells

Eoin Corcoran, Abidemi Olayinka, Mariana di Luca, Yusof Gusti, Roya Hakimjavadi, Brendan O’Connor, Eileen M. Redmond, Paul A. Cahill

Niche homeostasis in multi-lineage stem cell populations is maintained through intercellular redox gradients

Olivia Majhi, Aishwarya Chhatre, Tanvi Chaudhary, Devanjan Sinha

TGF-beta dynamically controls epithelial identity in a 3D model of human epiblast

Irene Zorzan, Elena Carbognin, Andrea Lauria, Valentina Proserpio, Davide Benegnù, Caterina Dalrio, Mattia Arboit, Irene Paolucci, Andrea Drusin, Monika Sledziowska, Gianluca Amadei, Salvatore Oliviero, Graziano Martello

Self-renewing Sox9+ osteochondral stem cells in the postnatal skeleton

Stephanie Farhat, Bahaeddine Tilouche, Spencer Short, Medjie Piron, T. Mark Campbell, Alex Fernandes, Mariya Somyk, Hina Bandukwala, Eric Arezza, Quentin Sastourne-Arrey, Katherine Reilly, Maria Abou Chakra, Gary Bader, Leo Kunz, Timm Schroeder, Sasha Carsen, Pierre Mattar, Jeffrey Dilworth, Daniel L. Coutu

Two transcriptional cascades orchestrate cockroach leg regeneration

Chonghua Ren, Yejie Wen, Shaojuan Zheng, Zheng Zhao, Ethan Yihao Li, Chenjing Zhao, Mingtao Liao, Liang Li, Xiaoshuai Zhang, Suning Liu, Dongwei Yuan, Wei Wang, Jifeng Fei, Sheng Li

Skeletal Muscle Satellite Cells Co-Opt the Tenogenic Gene Scleraxis to Instruct Regeneration

Yun Bai, Tyler Harvey, Minjie Hu, Colin Bilyou, Chen-Ming Fan

Gain of chromosome region 1q31.3 in human iPSCs confers growth advantage and alters contraction in derivative cardiomyocytes

Karina O. Brandão, Viviana Meraviglia, Daniela Salvatori, Xu Cao, Luca Sala, Loukia Yiangou, Mervyn P.H. Mol, Milena Bellin, Christine L. Mummery, Richard P. Davis

Basement membrane extract potentiates the endochondral ossification phenotype of bone marrow-derived mesenchymal stem cell-based cartilage organoids

Hinako Notoh, Satoshi Yamasaki, Nobuaki Suzuki, Atsuo Suzuki, Shuichi Okamoto, Takeshi Kanematsu, Naruko Suzuki, Akira Katsumi, Tetsuhito Kojima, Tadashi Matsushita, Shogo Tamura

Single-cell RNAseq reveals the pro-regenerative role of senescent FAPs in muscle regeneration

Cheng Chen, Marielle Saclier, Jérémy Chantrel, Sébastian Mella, Aurélie Chiche, Han Li

Aberrant Wnt activation in recurrent genetically variant human pluripotent stem cells impairs cardiomyocyte differentiation and phenotype

Theodore Wing, Christopher J. Price, Dylan Stavish, Owen Laing, Jack J. Riley, Alan Lam, Steve Oh, Yaser Atlasi, Ivana Barbaric

Ex vivo Expansion Potential of Murine Hematopoietic Stem Cells: A Rare Property Only Partially Predicted by Phenotype

Qinyu Zhang, Rasmus Olofzon, Anna Konturek-Ciesla, Ouyang Yuan, David Bryder

Pigmentation level of human iPSC-derived retinal pigment epithelium cell does not indicate a specific gene expression profile

Yoko Nakai-Futatsugi, Jianshi Jin, Taisaku Ogawa, Noriko Sakai, Akiko Maeda, Ken-ichi Hironaka, Masakazu Fukuda, Hiroki Danno, Yuji Tanaka, Seiji Hori, Katsuyuki Shiroguchi, Masayo Takahashi

Sequential genetic and epigenetic alterations in human pluripotent stem cells for recurrent abnormality

Yun-Jeong Kim, Byunghee Kang, Solbi Kweon, Sejin Oh, Dayeon Kim, Dayeon Gil, Hyeonji Lee, Jung-Hyun Kim, Ji Hyeon Ju, Tae-Young Roh, Chang Pyo Hong, Hyuk-Jin Cha

Quantifying stem cell derived islet graft volume and composition with [18F]F-DBCO-exendin and [18F]FDOPA positron emission tomography

Väinö Lithovius, Salla Lahdenpohja, Hazem Ibrahim, Jonna Saarimäki-Vire, Lotta Uusitalo, Hossam Montaser, Kirsi Mikkola, Cheng-Bin Yim, Thomas Keller, Johan Rajander, Diego Balboa, Tom Barsby, Olof Solin, Pirjo Nuutila, Tove J Grönroos, Timo Otonkoski

Stage-sensitive potential of isolated rabbit ICM to differentiate into extraembryonic lineages

Katarzyna Filimonow, Anna Choloniewska, Jan Choloniewski, Zofia E. Madeja, Katarzyna Barlowska, Joanna Grabarek, Berenika Plusa, Anna Piliszek

The transient formation of collaterals contributes to the restoration of the arterial tree during cardiac regeneration in neonatal mice

Lucile Miquerol, Rachel Sturny, Lucie Boulgakoff, Robert G Kelly

The role of satellite cell-derived TRIM28 in mechanical load- and injury-induced myogenesis

Kuan-Hung Lin, Jamie E Hibbert, Jake L Lemens, Melissa M. Torbey, Nathaniel D. Steinert, Philip M. Flejsierowicz, Kiley M. Melka, Marcos Lares, Vijayasaradhi Setaluri, Troy A. Hornberger

Shared features of blastula and neural crest stem cells evolved at the base of vertebrates

Joshua R. York, Anjali Rao, Paul B. Huber, Elizabeth N. Schock, Andrew Montequin, Sara Rigney, Carole LaBonne

Pharmacologically inducing regenerative cardiac cells by small molecule drugs

Wei Zhou, Kezhang He, Chiyin Wang, Pengqi Wang, Dan Wang, Bowen Wang, Han Geng, Hong Lian, Tianhua Ma, Yu Nie, Sheng Ding

In vitro differentiation of mouse pluripotent stem cells into glucocorticoid-producing adrenocortical cells

Ioannis Oikonomakos, Melina Tedesco, Fariba Jian Motamedi, Mirko Peitzsch, Serge Nef, Stefan Bornstein, Andreas Schedl, Charlotte Steenblock, Yasmine Neirijnck

Computational identification of key transcription factors for embryonic and postnatal Sox2+ dental epithelial stem cell

Fan Shao, Eric Van Otterloo, Huojun Cao

All three MutL complexes are required for repeat expansion in a human stem cell model of CAG-repeat expansion mediated glutaminase deficiency

Bruce Hayward, Daman Kumari, André B.P. van Kuilenburg, Karen Usdin

In vivo PSC differentiation as a platform to identify factors for improving the engraftability of cultured muscle stem cells

Ning Xie, Kathryn Robinson, Timothy Sundquist, Sunny S. K. Chan

| Plant development

Glutaredoxin regulation of primary root growth is associated with early drought stress tolerance in pearl millet

Carla de la Fuente, Alexandre Grondin, Bassirou Sine, Marilyne Debieu, Christophe Belin, Amir Hajjarpoor, Jonathan A. Atkinson, Sixtine Passot, Marine Salson, Julie Orjuela, Christine Tranchant-Dubreuil, Jean-Rémy Brossier, Maxime Steffen, Charlotte Morgado, Hang Ngan Dinh, Bipin K. Pandey, Julie Darmau, Antony Champion, Anne-Sophie Petitot, Celia Barrachina, Marine Pratlong, Thibault Mounier, Princia Nakombo-Gbassault, Pascal Gantet, Prakash Gangashetty, Yann Guédon, Vincent Vadez, Jean-Philippe Reichheld, Malcolm J. Bennett, Ndjido Kane, Soazig Guyomarc’h, Darren M. Wells, Yves Vigouroux, Laurent Laplaze

Warm temperature and mild water stress cooperatively promote root elongation

Scott Hayes, Cheuk Ka Leong, Wenyan Zhang, Marthe Lamain, Jasper Lamers, Thijs de Zeeuw, Francel Verstappen, Andreas Hiltbrunner, Christa Testerink

Strawberry phenotypic plasticity in flowering time is driven by interaction between genetic loci and temperature

Alexandre Prohaska, Aurélie Petit, Silke Lesemann, Pol Rey-Serra, Luca Mazzoni, Agnieszka Masny, José F. Sánchez-Sevilla, Aline Potier, Amèlia Gaston, Krzysztof Klamkowski, Christophe Rothan, Bruno Mezzetti, Iraida Amaya, Klaus Olbricht, Béatrice Denoyes

HD-Zip II transcription factors control distal stem cell fate in Arabidopsis roots by linking auxin signaling to the FEZ/SOMBRERO pathway

Marco Possenti, Giovanna Sessa, Altea Alfè, Luana Turchi, Valentino Ruzza, Massimiliano Sassi, Giorgio Morelli, Ida Ruberti

Quantitative Modeling of the Short-Term Response to Nitrogen Availability that Coordinates Early Events in Lateral Root Initiation

Allison Gaudinier, Lisa Van den Broeck, Miguel Moreno-Risueño, Joel Rodriguez-Medina, Rosangela Sozzani, Siobhan M. Brady

Leaf- and diverged shoot meristem programs shape the stem in rice

Katsutoshi Tsuda, Akiteru Maeno, Ayako Otake, Kae Kato, Wakana Tanaka, Ken-Ichiro Hibara, Ken-Ichi Nonomura

Diverse 3D cellular patterns underlie the development of Cardamine hirsuta and Arabidopsis thaliana ovules

Tejasvinee Atul Mody, Alexander Rolle, Nico Stucki, Fabian Roll, Ulrich Bauer, Kay Schneitz

Nodule organogenesis in Medicago truncatula requires local stage-specific auxin biosynthesis and transport

TT Xiao, D Shen, S Müller, J Liu, A van Seters, H Franssen, T Bisseling, O Kulikova, W Kohlen

Restriction of intercellular communication is required for organ regeneration

Itay Cohen, Hagit Hak, Jessica Perez-Sancho, Ziv Spiegelman, Idan Efroni

Nuclear GSH import precedes coordinated cell cycle changes during regeneration

Laura R Lee, Bruno Guillotin, Chanel Hutchison, Bénédicte Desvoyes, Crisanto Gutierrez, Kenneth David Birnbaum

Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing.

Joseph W Palmer, Nilesh Kumar, Luye An, Andrew C. White, M Shahid Mukhtar, Melissa L Harris

Overexpression of tomato SlBBX16 and SlBBX17 impacts fruit development and gibberellin metabolism

Valentina Dusi, Federica Pennisi, Daniela Fortini, Alejandro Atarés, Stephan Wenkel, Barbara Molesini, Tiziana Pandolfini

Flavonols improve thermotolerance in tomato pollen during germination and tube elongation by maintaining ROS homeostasis

Anthony E. Postiglione, Allison M. Delange, Mohammad Foteh Ali, Maarten Houben, Eric Y. Wang, Stacy L. Hahn, Colleen M. Roark, Molly Davis, Robert W. Reid, James B. Pease, Ann E. Loraine, Gloria K. Muday

Streamlined regulation of chloroplast development in the liverwort Marchantia polymorpha

Nataliya E. Yelina, Eftychios Frangedakis, Zhemin Wang, Tina B. Schreier, Jenna Rever, Marta Tomaselli, Edith Forestier, Kumari Billakurthi, Sibo Ren, Yahui Bai, Julia Stewart-Wood, Jim Haseloff, Silin Zhong, Julian M. Hibberd

A putative rhamnogalacturonan-II CMP-β-Kdo transferase identified using CRISPR/Cas9 gene edited callus to circumvent embryo lethality.

Yuan Zhang, Deepak Sharma, Yan Liang, Nick Downs, Fleur Dolman, Kristen Thorne, Ian Black, Jose Henrique Pereira, Paul D. Adams, Henrik Scheller, Malcolm O’Neill, Breeannna R Urbanowicz, Jenny C Mortimer

| Evo-devo

The functional evolution of collembolan Ubx on the regulation of abdominal appendage formation

Yan Liang, Yun-Xia Luan

Coevolution of longevity and female care of male gametes

Julian Baur, Mareike Koppik, Uroš Savković, Mirko Đorđević, Biljana Stojković, David Berger

Spontaneous Intersibling Polymorphism in the Development of Dopaminergic Neuroendocrine Cells in Sea Urchin Larvae: Impacts on the Expansion of Marine Benthic Species

Alexandra L. Obukhova, Marina Yu. Khabarova, Marina N. Semenova, Viktor V. Starunov, Elena E. Voronezhskaya, Evgeny G. Ivashkin

Extracellular symbiont colonizes insect during embryo development

Miguel Ángel González Porras, Inès Pons, Marleny García-Lozano, Shounak Jagdale, Christiane Emmerich, Benjamin Weiss, Hassan Salem

Expanded Expression of Pro-Neurogenic Factor SoxB1 during Larval Development of Gastropod Lymnaea stagnalis Suggests Preadaptation to Prolonged Neurogenesis in Mollusca

Anastasia I. Kurtova, Alexander D. Finoshin, Margarita S. Aparina, Guzel R. Gazizova, Olga S. Kozlova, Svetlana N. Voronova, Elena I. Shagimardanova, Evgeny G. Ivashkin, Elena E. Voronezhskaya

Reproductive life history may modulate selection on the germline mutation rate

Luke Zhu, Annabel Beichman, Kelley Harris

Conserved and novel enhancers regulate embryonic ventral midline gene expression in the Aedes aegypti single-minded locus

Isabella Schember, William Reid, Marc S. Halfon

Larval growth rate affects wing shape more than eyespot size in the seasonally polyphenic butterfly Melanitis leda

Freerk Molleman, Elizabeth M. Moore, Sridhar Halali, Ullasa Kodandaramaiah, Dheeraj Halali, Erik van Bergen, Paul M. Brakefield, Vicencio Oostra

A novel sperm-derived seminal fluid protein in Caenorhabditis nematodes

Katja R. Kasimatis, Christine Rehaluk, Locke Rowe, Asher D. Cutter

Sperm competition favours intermediate sperm size in a hermaphrodite

Santhosh Santhosh, Dieter Ebert, Tim Janicke

Uncovering the mosaic evolution of the carnivoran skeletal system

Chris J Law, Leslea J Hlusko, Jack Tseng

Development and patterning of a highly versatile visual system in spiders

Luis Baudouin Gonzalez, Anna Schönauer, Amber Harper, Saad Arif, Daniel J. Leite, Philip O. M. Steinhoff, Matthias Pechmann, Valeriia Telizhenko, Atal Pande, Carolin Kosiol, Alistair P. McGregor, Lauren Sumner-Rooney

Maternal investment evolves with larger body size and higher diversification rate in sharks and rays

Christopher G Mull, Matthew W Pennell, Kara E Yopak, Nicholas K Dulvy

Complex allometric relationships and ecological factors shape the development and evolution of eye size in the modular visual system of spiders

Kaylin Chong, Angelique Grahn, Craig D. Perl, Lauren Sumner-Rooney

Pronounced early differentiation underlies zebra finch gonadal germ cell development.

Matthew T Biegler, Kirubel Belay, Wei Wang, Christina Szi, Paul G Collier, Ji-Dung Luo, Bettina Haase, Gregory L. Gedman, Asha V. Sidhu, Elijah Harter, Carlos Rivera-Lopez, Kwame Amoako-Boadu, Olivier Fedrigo, Hagen U. Tilgner, Thomas T Carroll, Erich D. Jarvis, Anna L. Keyte

Cell Biology

IL-1β disrupts blood-brain barrier development by inhibiting endothelial Wnt/β-catenin signaling

Audrey R. Fetsko, Dylan J. Sebo, Lilyana B. Budzynski, Alli Scharbarth, Michael R. Taylor

Germ granule compartments coordinate specialized small RNA production

Xiangyang Chen, Ke Wang, Xuezhu Feng, Farees ud din Mufti, Demin Xu, Chengming Zhu, Xinya Huang, Chenming Zeng, Qile Jin, Xiaona Huang, Yong-hong Yan, Meng-qiu Dong, Yunyu Shi, Scott Kennedy, Shouhong Guang

A niche-derived non-ribosomal peptide triggers planarian sexual development

Melanie Issigonis, Katherine L. Browder, Rui Chen, James J. Collins, Phillip A. Newmark

The initiation and early development of the tubulin-containing cytoskeleton in the human parasite Toxoplasma gondii

Luisa F. Arias Padilla, John M. Murray, Ke Hu

Cortical F-actin filament organization corrals E-cadherin/HMR-1 during cytokinetic furrow ingression in C. elegans embryos

Debodyuti Mondal, Megha Rai, Anup Padmanabhan

Nuclear cytoophidia assembly represses transcriptional activity to control skeletal development and homeostasis

Cheng Xu, Zhixin Wei, Longfei Lv, Xiaoyu Dong, Wenwen Xia, Junqiao Xing, Hongni Liu, Xue Zhao, Yuan Liu, Weihua Wang, Haochen Jiang, Yeli Gong, Cong Liu, Kai Xu, Siyuan Wang, Yoshie Akimoto, Zhangfeng Hu

Mechanical transapical coupling of endometrial epithelial cells during implantation

Jun Sakurai, Noriyuki Kinoshita, Tetsuhisa Otani, Hiroshi Koyama, Mikio Furuse, Toshihiko Fujimori

Dynamic protein assembly and architecture of the large solitary membraneless organelle during germline development in the wasp Nasonia vitripennis

Kabita Kharel, Samuel J. Tindell, Allie Kemph, Ryan Schmidtke, Emma Alexander, Jeremy A. Lynch, Alexey L. Arkov

Cell shape anisotropy enhances cytoplasm viscoelastic resistance to stabilize mitotic spindle position during early embryo development

Jing Xie, Javad Najafi, Luc Lederer, Aude Nommick, Jeremy Salle, Serge Dmitrieff, Nicolas Minc

An RNAi screen to identify proteins required for cohesion rejuvenation during meiotic prophase in Drosophila oocytes

Muhammad A. Haseeb, Alana C. Bernys, Erin E. Dickert, Sharon E. Bickel

Amalgam plays a dual role in controlling the number of leg muscle progenitors and regulating their interactions with developing tendon

Blandine Moucaud, Elodie Prince, Elia Ragot, Yoan Renaud, Krzysztof Jagla, Cédric Soler

Primary cilia in osteoblasts and osteocytes are required for skeletal development and mechanotransduction

Mariana Moraes de Lima Perini, Julie N Pugh, Elizabeth M Scott, Karan Bhula, Austin Chirgwin, Olivia N Reul, Nicolas F Berbari, Jiliang Li

An important role for triglyceride in regulating spermatogenesis

Charlotte F. Chao, Yanina-Yasmin Pesch, Huaxu Yu, Chenjingyi Wang, Maria J. Aristizabal, Tao Huan, Guy Tanentzapf, Elizabeth J. Rideout

DHCR24-mediated sterol homeostasis during spermatogenesis is required for sperm mitochondrial sheath formation and impacts male fertility over time

Sona Relovska, Huafeng Wang, Xinbo Zhang, Pablo Fernández-Tussy, Kyung Jo Jeong, Jungmin Choi, Yajaira Suárez, Jeffrey G. McDonald, Carlos Fernández-Hernando, Jean-Ju Chung

Endosomal-lysosomal organellar assembly (ELYSA) structures coordinate lysosomal degradation systems through mammalian oocyte-to-embryo transition

Yuhkoh Satouh, Takaki Tatebe, Isei Tanida, Junji Yamaguchi, Yasuo Uchiyama, Ken Sato

Modelling

A model for maxilloturbinate morphogenesis in seals

Jonathan E. Kings, Lars P. Folkow, Øyvind Hammer, Signe Kjelstrup, Matthew J. Mason, Fengzhu Xiong, Eirik G. Flekkøy

Learning a conserved mechanism for early neuroectoderm morphogenesis

Matthew Lefebvre, Jonathan Colen, Nikolas Claussen, Fridtjof Brauns, Marion Raich, Noah Mitchell, Michel Fruchart, Vincenzo Vitelli, Sebastian J Streichan

Spectral decomposition unlocks ascidian morphogenesis

Joel Dokmegang, Emmanuel Faure, Patrick Lemaire, Ed Munro, Madhav Mani

Tools & Resources

An integrated transcriptomic cell atlas of human endoderm-derived organoids

Quan Xu, Lennard Halle, Soroor Hediyeh-zadeh, Merel Kuijs, Umut Kilik, Qianhui Yu, Tristan Frum, Lukas Adam, Shrey Parikh, Manuel Gander, Raphael Kfuri-Rubens, Dominik Klein, Zhisong He, Jonas Simon Fleck, Koen Oost, Maurice Kahnwald, Silvia Barbiero, Olga Mitrofanova, Grzegorz Maciag, Kim B. Jensen, Matthias Lutolf, Prisca Liberali, Joep Beumer, Jason R. Spence, Barbara Treutlein, Fabian J. Theis, J. Gray Camp

Development of a human heart-on-a-chip model using induced pluripotent stem cells, fibroblasts and endothelial cells

Yun Liu, Rumaisa Kamran, Xiaoxia Han, Mengxue Wang, Qiang Li, Daoyue Lai, Keiji Naruse, Ken Takahashi

Three-dimensional reconstruction of fetal rhesus macaque kidneys at single-cell resolution reveals complex inter-relation of structures

Lucie Dequiedt, André Forjaz, Jamie O. Lo, Owen McCarty, Pei-Hsun. Wu, Avi Rosenberg, Denis Wirtz, Ashley Kiemen

Imaging the dynamics of uterine contractions in early pregnancy

Madeline Dawson, Diana Flores, Lisa Zou, Shivani Anandasenthil, Rohit Mahesh, Olmo Zavala, Ripla Arora

Development of an mRNA electroporation method in immature mouse oocytes to visualize protein dynamics during early development

Yuhkoh Satouh, Emiko Suzuki, Keisuke Sasaki, Ken Sato

A rapid method for generating transplantable and biologically responsive colonic tissue from human induced pluripotent stem cells

William Dalleywater, Alexander V. Predeus, Batuhan Cakir, Pavel Mazin, Jayakumar Vadakekolathu, Sergio Rutella, Marian L. Meakin, Alison A. Ritchie, Shamir Montazid, Sara Cuevas Ocaña, Nadine Holmes, Victoria Wright, Fei Sang, Adam Bills, Declan Sculthorpe, Rasa Elmentaite, Sarah A. Teichmann, Shazia Irshad, Ian Tomlinson, Andrew Silver, Ricky D. Wildman, Nicholas R.F Hannan, Felicity R.A.J. Rose, Mohammad Ilyas

Benefits of timed mating over blind mating of mice to get timed embryos

M. Imran, M. Mohsin, M. Anwar, M. Khurshid

Temporal recording of mammalian development and precancer

Mirazul Islam, Yilin Yang, Alan J. Simmons, Vishal M. Shah, Musale Krushna Pavan, Yanwen Xu, Naila Tasneem, Zhengyi Chen, Linh T. Trinh, Paola Molina, Marisol A. Ramirez-Solano, Iannish Sadien, Jinzhuang Dou, Ken Chen, Mark A Magnuson, Jeffrey Rathmell, Ian G Macara, Douglas J Winton, Qi Liu, Hamim Zafar, Reza Kalhor, George M. Church, Martha J. Shrubsole, Robert J. Coffey Jr., Ken Lau

Characterization and hierarchy of the spermatogonial stem cell compartment in human spermatogenesis by spectral cytometry using a 16-colors panel

C. Lapoujade, M. Blanco, M. Givelet, A.S Gille, I. Allemand, L. Lenez, N. Thiounn, S. Roux, J.P. Wolf, C. Patrat, L. Riou, V. Barraud-Lange, P. Fouchet

Temporal Transcriptome Analysis Uncovers Regulatory Modules Programming Embryo Development from Embryonic Morphogenesis to Post-Germination

Yen-Ching Wang, Wei-Hsun Hsieh, Chu-Jun Huang, Ya-Ting Jhan, Junpeng Zhan, Ching-Chun Chang, Tzung-Fu Hsieh, Jer-Young Lin

Research practice & education

Analysis of NIH K99/R00 Awards and the Career Progression of Awardees

Nicole C Woitowich, Sarah R Hengel, Christopher Solis, Tauras P Vilgalys, Joel Babdor, Daniel J Tyrrell

Setting a trajectory for CO2 emission reduction in academic research: a case study of a French biophysics laboratory

Caroline Giuglaris, Jean de Seze

Best Paper awards lack transparency, inclusivity, and support for Open Science

Malgorzata Lagisz, Joanna Rutkowska, Upama Aich, Robert M. Ross, Manuela S. Santana, Joshua Wang, Nina Trubanová, Matthew J. Page, Andrew Adrian Yu Pua, Yefeng Yang, Bawan Amin, April Robin Martinig, Adrian Barnett, Aswathi Surendran, Ju Zhang, David N. Borg, Jafsia Elisee, James G. Wrightson, Shinichi Nakagawa

Beyond Active Learning: Using 3-Dimensional Learning to Create Scientifically Authentic, Student-Centered Classrooms

Melanie M Cooper, Marcos D. Caballero, Justin H. Carmel, Erin M. Duffy, Diane Ebert-May, Cori L. Fata-Hartley, Deborah G. Herrington, James T. Laverty, Paul C. Nelson, Lynmarie A. Posey, Jon R. Stoltzfus, Ryan L. Stowe, Ryan D. Sweeder, Stuart Tessmer, Sonia M. Underwood

Rendering protein structures inside cells at the atomic level with Unreal Engine

Muyuan Chen

Studentsourcing – aggregating and re-using data from a practical cell biology course

Joachim Goedhart

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