PhD position available – Investigating modulators of disease progression in GATA2 deficiency

A fully funded 4-year PhD position has become available in the Monteiro Lab (https://passinhas.wixsite.com/monteiro-lab) to investigate novel modulators of blood stem cell fitness that halt or reverse bone marrow failure in in vitro and in an in vivo zebrafish model of GATA2 deficiency.

GATA2 deficiency is a rare leukaemia predisposition syndrome that leads to bone marrow failure and progression to acute myeloid leukaemia in patients at a median age of 20. This project is a collaboration between the Monteiro and Higgs Lab at the Department of Cancer and Genomic Sciences, University of Birmingham, UK, with funding from the LifeArc Centre for Acceleration of Rare Disease Trials (ARDT).

Deadline: 6^th April 2025

Eligibility

Candidates are expected to hold (or be about to obtain) a minimum upper second-class honours degree (or equivalent) in biology, biochemistry or in a related area/subject. Candidates with an interest in blood stem cell biology and experience in in vitro cell models, in vivo zebrafish models of disease or compound screening are encouraged to apply.

Applications are invited from UK Home students only (British citizens, Irish citizen, or candidates with settled status in the UK).

Fees and funding

Support is for 4 years including a stipend, home rate tuition fees, research expenses and support for training and career development.

How to apply

Interested candidates should apply directly to the supervisor by email, providing the following:

1. Detailed CV, including your nationality and country of birth;
2. Covering letter highlighting your research experience/capabilities and why you wish to undertake a PhD in the ADRT;
3. Names and addresses of two referees;
4. Copies of degree certificates with transcripts written in English;

Email: r.monteiro@bham.ac.uk

FindAPhD advert: https://www.findaphd.com/phds/project/investigating-modulators-of-disease-progression-in-gata2-deficiency/?p183316