the community site for and by developmental biologists

July in Preprints

Posted by , on 6 August 2021

Welcome to our gallop through the preprints in developmental biology (and related subjects) published in July.

The preprints this month are hosted on bioRxiv, arXiv and preprints.org – use the links below to get to the section you want. Stand-out section for this month may be the Tools & Resources with some exciting new tools and methodologies.

Developmental biology

Cell Biology

Modelling

Reviews

Tools & Resources

Research practice & education

Developmental biology

| Patterning & signalling

Identification and characterization of hPSC-derived FOXA2+ progenitor cells with ventricular cardiac differentiation potential
Damelys Calderon, Nadeera Wickramasinghe, Leili Sarrafha, Christoph Schaniel, Shuibing Chen, Mark Tomishima, Nicole C. Dubois

Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner
Sun-Hee Hwang, Bandarigoda N. Somatilaka, Kevin White, Saikat Mukhopadhyay

TGF-β modulates cell fate in human ES cell-derived foregut endoderm by inhibiting multiple endogenous signaling pathways
Nina Sofi Funa, Kristian Honnens de Lichtenberg, Maria Skjøtt Hansen, Jonas van Cuyl Kuylenstierna, Kim Bak Jensen, Yi Miao, K. Christopher Garcia, Palle Serup

Understanding Mechanisms of Chamber-Specific Differentiation Through Combination of Lineage Tracing and Single Cell Transcriptomics
David M. Gonzalez, Nadine Schrode, Tasneem Ebrahim, Kristin G. Beaumont, Robert Sebra, Nicole C. Dubois

Reciprocal regulation of Shh trafficking and H2O2 levels via a noncanonical BOC-Rac1 pathway
Marion Thauvin, Irène Amblard, Christine Rampon, Aurélien Mourton, Isabelle Queguiner, Chenge Li, Arnaud Gautier, Alain Joliot, Michel Volovitch, Sophie Vriz

Calcium signaling mediates mechanotransduction at the multicellular stage of Dictyostelium discoideum
Hidenori Hashimura, Yusuke V. Morimoto, Yusei Hirayama, Masahiro Ueda

Timelapse imaging of living eye discs from Gallagher, et al.

Emergence of a geometric pattern of cell fates from tissue-scale mechanics in the Drosophila eye
Kevin D. Gallagher, Madhav Mani, Richard W. Carthew

IL7Rα is required for hematopoietic stem cell reconstitution of tissue-resident lymphoid cells
Atesh K. Worthington, Taylor S. Cool, Donna M. Poscablo, Adeel Hussaini, Anna E. Beaudin, E. Camilla Forsberg

PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes
Nadeera M. Wickramasinghe, David Sachs, Bhavana Shewale, David M. Gonzalez, Priyanka Dhanan-Krishnan, Denis Torre, Elizabeth LaMarca, Serena Raimo, Rafael Dariolli, Madhavika N. Serasinghe, Joshua Mayourian, Robert Sebra, Kristin Beaumont, Ravi Iyengar, Deborah L. French, Arne Hansen, Thomas Eschenhagen, Jerry E. Chipuk, Eric A. Sobie, Adam Jacobs, Schahram Akbarian, Harry Ischiropoulos, Avi Ma’ayan, Sander M. Houten, Kevin Costa, Nicole C. Dubois

TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells
Anna Osnato, Stephanie Brown, Christel Krueger, Simon Andrews, Amanda J. Collier, Shota Nakanoh, Mariana Quiroga Londoño, Brandon T. Wesley, Daniele Muraro, Sophie Brumm, Kathy Niakan, Ludovic Vallier, Daniel Ortmann, Peter J. Rugg-Gunn

Myeloid-to-mesenchymal NGF-p75 signaling coordinates skeletal cell migration during repair
Jiajia Xu, Zhao Li, Robert J. Tower, Stefano Negri, Yiyun Wang, Carolyn A. Meyers, Takashi Sono, Qizhi Qin, Amy Lu, Edward F. McCarthy, Thomas L. Clemens, Aaron W. James

A local insulin reservoir ensures developmental progression in condition of nutrient shortage in Drosophila
Suhrid Ghosh, Weihua Leng, Michaela Wilsch-Bräuninger, Pierre Léopold, Suzanne Eaton

CatSper mediates the chemotactic behavior and motility of the ascidian sperm
Taiga Kijima, Daisuke Kurokawa, Yasunori Sasakura, Michio Ogasawara, Satoe Aratake, Kaoru Yoshida, Manabu Yoshida

C2CD6 is required for assembly of the CatSper calcium channel complex and fertilization
Fang Yang, Maria Gracia Gervasi, N. Adrian Leu, Darya A. Tourzani, Gordon Ruthel, Pablo E. Visconti, P. Jeremy Wang

Saraswathy, et al. Mindbomb1 regulates convergent extension in zebrafish

The E3 Ubiquitin Ligase Mindbomb1 controls zebrafish Planar Cell Polarity
Vishnu Muraleedharan Saraswathy, Priyanka Sharma, Akshai Janardhana Kurup, Sophie Polès, Morgane Poulain, Maximilian Fürthauer

ECM-integrin signalling instructs cellular position-sensing to pattern the early mouse embryo
Esther Jeong Yoon Kim, Lydia Sorokin, Takashi Hiiragi

ERp44 is Required for Endocardial Cushion Development by Regulating VEGFA Secretion in Myocardium
Youkun Bi, Zhiguang Yang, Meng Jin, Kui Zhai, Jun Wang, Yang Mao, Yang Liu, Mingqin Ding, Huiwen Wang, Fengchao Wang, Guangju Ji

The blood vasculature instructs lymphatics patterning in a SOX7 dependent manner
Ivy Kim-Ni Chiang, Winnie Luu, Key Jiang, Nils Kirschnick, Mehdi Moustaqil, Tara Davidson, Emmanuelle Lesieur, Renae Skoczylas, Valerie Kouskoff, Jan Kazenwadel, Luis Arriola-Martinez, Emma Sierecki, Yann Gambin, Kari Alitalo, Friedmann Kiefer, Natasha L. Harvey, Mathias Francois

Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells
Di Peng, Koji Ando, Marleen Gloger, Renae Skoczylas, Naoki Mochizuki, Christer Betsholtz, Shigetomo Fukuhara, Katarzyna Koltowska

Acquisition of alveolar fate and differentiation competence by human fetal lung epithelial progenitor cells
Kyungtae Lim, Walfred Tang, Dawei Sun, Peng He, Sarah A. Teichmann, John C. Marioni, Kerstin B. Meyer, Emma L. Rawlins

The mutual repression between Pax2 and Snail factors regulates the epithelial/mesenchymal state during intermediate mesoderm differentiation
Juan M. Fons, Oscar H. Ocaña, M. Angela Nieto

Retinoic acid fluctuation activates an uneven, direction-dependent network-wide robustness response in early embryogenesis
Madhur Parihar, Liat Bendelac-Kapon, Michal Gur, Tali Abbou, Abha Belorkar, Sirisha Achanta, Keren Kinberg, Rajanikanth Vadigepalli, Abraham Fainsod

Embryogenesis in Mneiopsis leidyi from Presnell and Browne

Krüppel-like factor gene function in the ctenophore Mnemiopsis leidyi assessed by CRISPR/Cas9-mediated genome editing
Jason S Presnell, William E Browne

The extracellular matrix gene, Svep1, orchestrates airway patterning and the transition from lung branching morphogenesis to alveolar maturation in the mouse
N Foxworth, J Wells, S Ocaña-Lopez, S Muller, J Denegre, K Palmer, T McGee, W Memishian, SA Murray, PK Donahoe, CJ Bult, M Loscertales

Characterisation of the role and regulation of Ultrabithorax in sculpting fine-scale leg morphology
Alexandra D. Buffry, Sebastian Kittelmann, Alistair P. McGregor

Fast transcriptional activation of developmental signalling pathways during wound healing of the calcareous sponge Sycon ciliatum
Cüneyt Caglar, Alexander Ereskovsky, Mary Laplante, Daria Tokina, Sven Leininger, Ilya Borisenko, Genevieve Aisbett, Di Pan, Marcin Adamski, Maja Adamska

The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo
John Isaac Murray, Elicia Preston, Jeremy P. Crawford, Jonathan D. Rumley, Prativa Amom, Breana D. Anderson, Priya Sivaramakrishnan, Shaili D. Patel, Barrington Alexander Bennett, Teddy D. Lavon, Felicia Peng, Amanda L. Zacharias

Hypoxia induces a transcriptional early primitive streak signature in pluripotent cells enhancing spontaneous elongation and lineage representation in gastruloids
Natalia López-Anguita, Seher Ipek Gassaloglu, Maximilian Stötzel, Marina Typou, Iiris Virta, Sara Hetzel, René Buschow, Burak Koksal, Derya Atilla, Ronald Maitschke-Rajasekharan, Rui Chen, Alexandra L. Mattei, Ivan Bedzhov, David Meierhofer, Alexander Meissner, Jesse V. Veenvliet, Aydan Bulut-Karslioglu

Direct programming of human mammary self-organised organoids by miR-106a-3p
F. Delom, M. Puceat, D. Fessart

MyD88-dependent TLR signaling oppositely regulates hematopoietic progenitor and stem cell formation in the embryo
Laura F. Bennett, Melanie D. Mumau, Yan Li, Nancy A. Speck

Imaging blood flow in zebrafish embryos in Greysson-Wong, et al.

Venous activation of MEK/ERK drives development of arteriovenous malformation and blood flow anomalies with loss of Rasa1
Jasper Greysson-Wong, Rachael Rode, Jae-Ryeon Ryu, Kristina D. Rinker, Sarah J. Childs

The Imprinted Igf2-Igf2r Axis is Critical for Matching Placental Microvasculature Expansion to Fetal Growth
Ionel Sandovici, Aikaterini Georgopoulou, Vicente Pérez-García, Antonia Hufnagel, Jorge López-Tello, Brian Y.H. Lam, Samira N. Schiefer, Chelsea Gaudreau, Fátima Santos, Katharina Hoelle, Giles S.H. Yeo, Keith Burling, Moritz Reiterer, Abigail L. Fowden, Graham J. Burton, Cristina M. Branco, Amanda N. Sferruzzi-Perri, Miguel Constância

A Non-Canonical Raf Function Is Required for Dorsal-Ventral Patterning During Drosophila Embryogenesis
Jay B. Lusk, Ellora Hui Zhen Chua, Prameet Kaur, Isabelle Chiao Han Sung, Wen Kin Lim, Vanessa Yuk Man Lam, Nathan Harmston, Nicholas S. Tolwinski

Nociceptor subtypes are born continuously over DRG development peaking at E10.5—E11.5
Mark A. Landy, Megan Goyal, Helen C. Lai

Bmmp influences wing shape by regulating anterior-posterior and proximal-distal axis development
Yunlong Zou, Xin Ding, Li Zhang, Lifeng Xu, Shubo Liang, Hai Hu, Fangyin Dai, Xiaoling Tong

Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids
Yasuhiro Umemura, Nobuya Koike, Yoshiki Tsuchiya, Hitomi Watanabe, Gen Kondoh, Ryoichiro Kageyama, Kazuhiro Yagita

Ecdysone coordinates plastic growth with robust pattern in the developing wing
André Nogueira Alves, Marisa Mateus Oliveira, Takashi Koyama, Alexander Shingleton, Christen Mirth

| Morphogenesis & mechanics

Ankyrin2 in the fly brain from Schwartz, et al.

Ankyrin2 is required for neuronal morphogenesis and long-term memory and interacts genetically with HDAC4
Silvia Schwartz, Sarah J Wilson, Tracy K Hale, Helen L Fitzsimons

Primary cilia drive postnatal tidemark patterning in articular cartilage by coordinating responses to Indian Hedgehog and mechanical load
Danielle Rux, Kimberly Helbig, Biao Han, Courtney Cortese, Eiki Koyama, Lin Han, Maurizio Pacifici

The myotendinous junction marker collagen XXII enables zebrafish postural control learning and optimal swimming performance through its force transmission activity
Marilyne Malbouyres, Alexandre Guiraud, Christel Lefrançois, Mélanie Salamito, Pauline Nauroy, Laure Bernard, Frédéric Sohm, Bruno Allard, Florence Ruggiero

Zic1 advances epaxial myotome morphogenesis to cover the neural tube via Wnt11r
Ann Kathrin Heilig, Ryohei Nakamura, Atsuko Shimada, Yuka Hashimoto, Yuta Nakamura, Joachim Wittbrodt, Hiroyuki Takeda, Toru Kawanishi

ERK-mediated Curvature Feedback Regulates Branching Morphogenesis in Lung Epithelial Tissue
Tsuyoshi Hirashima, Michiyuki Matsuda

Özgüç, et al. measure contractility in the mouse embryo

Zygotic contractility awakening during mouse preimplantation development
Özge Özgüç, Ludmilla de Plater, Varun Kapoor, Anna Francesca Tortorelli, Jean-Léon Maître

3D viscoelastic drag forces contribute to cell shape changes during organogenesis in the zebrafish embryo
Paula C. Sanematsu, Gonca Erdemci-Tandogan, Himani Patel, Emma M. Retzlaff, Jeffrey D. Amack, M. Lisa Manning

Cyp26b1 restrains murine heart valve growth during development
Neha Ahuja, Max S. Hiltabidle, Hariprem Rajasekhar, Haley R. Barlow, Edward Daniel, Sophie Voss, Ondine Cleaver, Caitlin Maynard

Periosteum-derived podoplanin-expressing stromal cells regulate nascent vascularization during epiphyseal marrow development
Shogo Tamura, Masato Mukaide, Yumi Katsuragi, Wataru Fujii, Koya Odaira, Nobuaki Suzuki, Shuichi Okamoto, Atsuo Suzuki, Takeshi Kanematsu, Akira Katsumi, Akira Takagi, Katsue Suzuki-Inoue, Tadashi Matsushita, Tetsuhito Kojima, Fumihiko Hayakawa

Mechanics defines the spatial pattern of compensatory proliferation
Takumi Kawaue, Ivan Yow, Anh Phuong Le, Yuting Lou, Mavis Loberas, Murat Shagirov, Jacques Prost, Tetsuya Hiraiwa, Benoit Ladoux, Yusuke Toyama

Characterisation of the transcriptional dynamics underpinning the function, fate, and migration of the mouse Anterior Visceral Endoderm
Shifaan Thowfeequ, Jonathan Fiorentino, Di Hu, Maria Solovey, Sharon Ruane, Maria Whitehead, Bart Vanhaesebroeck, Antonio Scialdone, Shankar Srinivas

Co-option of local and systemic immune responses by the hormonal signalling system triggering metamorphosis in Drosophila melanogaster
Catarina Nunes, Takashi Koyama, Élio Sucena

Evolution of a confluent gut epithelium under cyclic stretching
Lauriane Gérémie, Efe Ilker, Moencopi Bernheim-Dennery, Charles Cavaniol, Jean-Louis Viovy, Danijela Matic Vignjevic, Jean-François Joanny, Stéphanie Descroix

Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics
Kai Weißenbruch, Justin Grewe, Marc Hippler, Magdalena Fladung, Moritz Tremmel, Kathrin Stricker, Ulrich S. Schwarz, Martin Bastmeyer

Modeling lung cell development using human pluripotent stem cells
Shuk Yee Ngan, Henry Quach, Joshua Dierolf, Onofrio Laselva, Jin-A Lee, Elena Huang, Maria Mangos, Sunny Xia, Amy P. Wong

Pax6 loss alters the morphological and electrophysiological development of mouse prethalamic neurons
Tian Tian, Idoia Quintana-Urzainqui, Zrinko Kozić, Thomas Pratt, David J. Price

Self-organized morphogenesis of a human neural tube in vitro by geometric constraints
Eyal Karzbrun, Aimal H. Khankhel, Heitor C. Megale, Stella M. K. Glasauer, Yofiel Wyle, George Britton, Aryeh Warmflash, Kenneth S. Kosik, Eric D. Siggia, Boris I. Shraiman, Sebastian J. Streichan

Imaging the vasculature in zebrafish from Chen, et al.

Blood flow coordinates collective endothelial cell migration during vascular plexus formation and promotes angiogenic sprout regression via vegfr3/flt4
Yan Chen, Zhen Jiang, Katherine H. Fisher, Hyejeong R. Kim, Paul C. Evans, Robert N. Wilkinson

DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells
Jason K. H. Lai, Pearlyn J. Y. Toh, Hamizah A. Cognart, Geetika Chouhan, Timothy E. Saunders

Annexin A1 is a polarity cue that directs planar mitotic spindle orientation during mammalian epithelial morphogenesis
Maria Fankhaenel, Farahnaz Sadat Golestan Hashemi, Manal Mosa Hosawi, Larissa Mourao, Paul Skipp, Xavier Morin, Colinda L.G.J. Scheele, Salah Elias

Active Cell Divisions Generate Exotic Fourfold Orientationally Ordered Phase in Living Tissue
Dillon Cislo, Haodong Qin, Fengshuo Yang, Mark J. Bowick, Sebastian J. Streichan

Extracellular mechanical forces drive endocardial cell volume decrease during cardiac valve morphogenesis
Hélène Vignes, Christina Vagena-Pantoula, Mangal Prakash, Caren Norden, Florian Jug, Julien Vermot

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development
Timothy J Mead, Daniel R Martin, Lauren W Wang, Stuart A Cain, Cagri Gulec, Elisabeth Cahill, Joseph Mauch, Dieter P Reinhardt, Cecilia W Lo, Clair Baldock, Suneel APTE

| Genes & genomes

TAF4b transcription networks regulating early oocyte differentiation
Megan A. Gura, Sona Relovska, Kimberly M. Abt, Kimberly A. Seymour, Tong Wu, Haskan Kaya, James M. A. Turner, Thomas G. Fazzio, Richard N. Freiman

Oct1 recruits the histone lysine demethylase Utx to canalize lineage specification
Jelena Perovanovic, Yifan Wu, Zuolian Shen, Erik Hughes, Mahesh B. Chandrasekharan, Dean Tantin

Retinal ganglion cell-specific genetic regulation in primary open angle glaucoma
Maciej S. Daniszewski, Anne Senabouth, Helena H. Liang, Xikun Han, Grace E. Lidgerwood, Damián Hernández, Priyadharshini Sivakumaran, Jordan E. Clarke, Shiang Y. Lim, Jarmon G. Lees, Louise Rooney, Lerna Gulluyan, Emmanuelle Souzeau, Stuart L. Graham, Chia-Ling Chan, Uyen Nguyen, Nona Farbehi, Vikkitharan Gnanasambandapillai, Rachael A. McCloy, Linda Clarke, Lisa Kearns, David A Mackey, Jamie E. Craig, Stuart MacGregor, Joseph E. Powell, Alice Pébay, Alex W. Hewitt

Liang, et al. use scRNAseq to identify the major cell types in the mouse liver

Temporal Analyses of Postnatal Liver Development and Maturation by Single Cell Transcriptomics
Yan Liang, Kota Kaneko, Bing Xin, Jin Lee, Xin Sun, Kun Zhang, Gen-Sheng Feng

WDR82-binding long non-coding RNA lncEry controls mouse erythroid differentiation and maturation
Shangda Yang, Guohuan Sun, Peng Wu, Cong Chen, Yijin Kuang, Zhaofeng Zheng, Yicheng He, Quan Gu, Ting Lu, Caiying Zhu, Fengjiao Wang, Fanglin Gou, Zining Yang, Xiangnan Zhao, Shiru Yuan, Liu Yang, Shihong Lu, Yapu Li, Xue Lv, Fang Dong, Yanni Ma, Jia Yu, Lai Guan Ng, Lihong Shi, Jing Liu, Hui Cheng, Tao Cheng

Multivariate genome-wide association study on tissue-sensitive diffusion metrics identifies key molecular pathways for axonal growth, synaptogenesis, and astrocyte-mediated neuroinflammation
Chun Chieh Fan, Robert Loughnan, Carolina Makowski, Diliana Pecheva, Chi-Hua Chen, Donald Hagler, Wesley K. Thompson, Nadine Parker, Dennis van der Meer, Oleksandr Frei, Ole A. Andreassen, Anders M. Dale

miR-9a regulates levels of both rhomboid mRNA and protein in the early Drosophila melanogaster embryo
Lorenzo Gallicchio, Sam Griffiths-Jones, Matthew Ronshaugen

Minimal synthetic enhancers reveal control of the probability of transcriptional engagement and its timing by a morphogen gradient
Armando Reimer, Simon Alamos, Clay Westrum, Meghan A. Turner, Paul Talledo, Jiaxi Zhao, Hernan G Garcia

Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF
Maria Jose Andreu, Alba Alvarez-Franco, Marta Portela, Daniel Gimenez-Llorente, Ana Cuadrado, Claudio Badia-Careaga, Maria Tiana, Ana Losada, Miguel Manzanares

Characterization of the Drosophila adult hematopoietic system reveals a rare cell population with differentiation and proliferation potential
Manon Boulet, Yoan Renaud, François Lapraz, Billel Benmimoun, Laurence Vandel, Lucas Waltzer

Downregulation of WT1 transcription factor gene expression is required to promote myocardial fate
Ines J. Marques, Alexander Ernst, Prateek Arora, Andrej Vianin, Tanja Hetke, Andrés Sanz-Morejón, Uta Naumann, Adolfo Odriozola, Xavier Langa, Laura Andrés-Delgado, David Haberthür, Benoît Zuber, Carlos Torroja, Ruslan Hlushchuk, Marco Osterwalder, Filipa Simões, Christoph Englert, Nadia Mercader

Unraveling three-dimensional chromatin structural dynamics during spermatogonial differentiation
Yi Zheng, Lingkai Zhang, Long Jin, Pengfei Zhang, Fuyuan Li, Ming Guo, Qiang Gao, Yao Zeng, Mingzhou Li, Wenxian Zeng

Interactome of Ago1 and Ago2 from Müller, et al.

AGO1 regulates major satellite transcripts and H3K9me3 distribution at pericentromeric regions in mESCs
Madlen Müller, Tara Fäh, Moritz Schäfer, Janina Luitz, Patrick Stalder, Rajika Arora, Richard Patryk Ngondo, Constance Ciaudo

Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline
Jacqueline V. Graniel, Kamlesh Bisht, Ann Friedman, James White, Eric Perkey, Ashley Vanderbeck, Alina Moroz, Léolène J. Carrington, Joshua D. Brandstadter, Frederick Allen, Adrienne Niederriter Shami, Peedikayil Thomas, Aniela Crayton, Mariel Manzor, Anna Mychalowych, Jennifer Chase, Saher S. Hammoud, Catherine E. Keegan, Ivan Maillard, Jayakrishnan Nandakumar

Inferring kinetic parameters of oscillatory gene regulation from single cell time series data
Joshua Burton, Cerys S. Manning, Magnus Rattray, Nancy Papalopulu, Jochen Kursawe

The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in C. elegans
Josh Saul, Takashi Hirose, H. Robert Horvitz

| Stem cells, regeneration & disease modelling

Small-molecule cocktails induce the differentiation of human adipose-derived mesenchymal stem cells into hepatocyte-like cells
Kan Yin, Yang Xu, Di Wu, Weiyan Yang, Naijun Dong, Ning Li, Robert Chunhua Zhao

The age and mouse sperm quality – a flow cytometry investigation
Federica Zacchini, Michal Bochenek, Simona Bisogno, Alan Chan, Grazyna Ewa Ptak

A rapid F0 CRISPR screen in zebrafish to identify regulators of neuronal development in the enteric nervous system
Ann E Davidson, Nora RW Straquadine, Sara A Cook, Christina G Liu, Julia Ganz

Knockout of E-cadherin in adult mouse epithelium results in emphysema and airway disease
Baishakhi Ghosh, Jeffrey Loube, Shreeti Thapa, Erin Capodanno, Saborny Mahmud, Mirit Girgis, Si Chen, Kristine Nishida, Linyan Ying, Carter Swaby, Ara Wally, Debarshi Bhowmik, Michael Zaykaner, Wayne Mitzner, Venkataramana K. Sidhaye

Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction
Hsuan Peng, Kazuhiro Shindo, Renée R. Donahue, Erhe Gao, Brooke M. Ahern, Bryana M. Levitan, Himi Tripathi, David Powell, Ahmed Noor, Jonathan Satin, Ashley W. Seifert, Ahmed Abdel-Latif

High-resolution single cell transcriptome analysis of zebrafish sensory hair cell regeneration
Sungmin Baek, Nhung T. T. Tran, Daniel C. Diaz, Ya-Yin Tsai, Joaquin Navajas Acedo, Mark E. Lush, Tatjana Piotrowski

Transcriptomic analysis of mdx mouse muscles reveals a signature of early human Duchenne muscular dystrophy
Evelyn Ralston, Gustavo Gutierrez-Cruz, Aster Kenea, Stephen R. Brooks

Femurs of mice analysed by micro computed tomography by Khedgikar, et al

LGR6 is necessary for attaining peak bone mass and regulates osteogenesis through differential ligand use
Vikram Khedgikar, Julia F. Charles, Jessica A. Lehoczky

Ing4-deficiency enhances HSC quiescence and confers resistance to inflammatory stress
Zanshé Thompson, Georgina A. Anderson, Melanie Rodriguez, Seth Gabriel, Vera Binder, Alison M. Taylor, Katie L. Kathrein

The roles of NADPH oxidases during adult zebrafish fin regeneration
Kunal Chopra, Milda Folkmanaitė, Liam Stockdale, Vishali Shathish, Shoko Ishibashi, Rachel Bergin, Jorge Amich, Enrique Amaya

Human engineered skeletal muscle of hypaxial origin from pluripotent stem cells with advanced function and regenerative capacity
Mina Shahriyari, Md Rezaul Islam, M. Sadman Sakib, Anastasia Rika, Dennis Krüger, Lalit Kaurani, Harithaa Anandakumar, Orr Shomroni, Matthias Schmidt, Gabriela Salinas, Andreas Unger, Wolfgang A. Linke, Jana Zschüntzsch, Jens Schmidt, André Fischer, Wolfram-Hubertus Zimmermann, Malte Tiburcy

Newly Emergent Apelin Expressing Endothelial Stem-like Cells Orchestrate Lung Microvascular Repair
Rafael Soares Godoy, David P Cook, Nicholas D Cober, Yupu Deng, Liyuan Wang, Ananya Chakravarti, Katelynn Rowe, Duncan J Stewart

Temporal regulation of Pten is essential for retina regeneration in zebrafish
Shivangi Gupta, Poonam Sharma, Mansi Chaudhary, Sharanya Premraj, Simran Kaur, V Vijithkumar, Rajesh Ramachandran

Critical genetic program for Drosophila imaginal disc regeneration revealed by single-cell analysis
Melanie I. Worley, Nicholas J. Everetts, Riku Yasutomi, Nir Yosef, Iswar K. Hariharan

Traip Mitotic Function Controls Brain Size
Ryan S. O’Neill, Nasser M. Rusan

Zeb2 DNA-binding sites in ES cell derived neuroprogenitor cells reveal autoregulation and align with neurodevelopmental knockout mouse and disease phenotypes
Judith C. Birkhoff, Anne L. Korporaal, Rutger W.W. Brouwer, Claudia Milazzo, Lidia Mouratidou, Mirjam C.G.N. van den Hout, Wilfred F.J. van IJcken, Danny Huylebroeck, Andrea Conidi

Embigin deficiency leads to delayed embryonic lung development and high neonatal mortality
Salli Talvi, Johanna Jokinen, Kalle Sipilä, Pekka Rappu, Fu-Ping Zhang, Matti Poutanen, Pia Rantakari, Jyrki Heino

Severe neural tube defects due to failure of closure initiation can arise without abnormality of neuroepithelial convergent extension
Oleksandr Nychyk, Gabriel L. Galea, Matteo Molè, Dawn Savery, Nicholas D.E. Greene, Philip Stanier, Andrew J. Copp

Tfap2b specifies an embryonic melanocyte stem cell that retains adult multi-fate potential
Alessandro Brombin, Daniel J. Simpson, Jana Travnickova, Hannah R. Brunsdon, Zhiqiang Zeng, Yuting Lu, Tamir Chandra, E. Elizabeth Patton

Neutrophil and natural killer cell imbalances prevent muscle stem cell mediated regeneration following murine volumetric muscle loss
Jacqueline A. Larouche, Sarah J. Kurpiers, Benjamin A. Yang, Carol Davis, Paula M. Fraczek, Matthew Hall, Susan V. Brooks, Lonnie D. Shea, Carlos A. Aguilar

Regeneration in the sea anemone Nematostella vectensis from Johnston, et al.

Whole body regeneration deploys a rewired embryonic gene regulatory network logic
Hereroa Johnston, Jacob F. Warner, Aldine R. Amiel, K Nedoncelle, João E Carvalho, Eric Röttinger

Tumour Suppressor Parafibromin/Hyrax Governs Cell Polarity and Centrosome Assembly in Neural Stem Cells
Qiannan Deng, Cheng Wang, Chwee Tat Koe, Jan Peter Heinen, Ye Sing Tan, Song Li, Cayetano Gonzalez, Wing-Kin Sung, Hongyan Wang

An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro/adipogenic progenitors in fibrodysplasia ossificans progressiva mice
John B. Lees-Shepard, Sean J. Stoessel, Julian Chandler, Keith Bouchard, Patricia Bento, Lorraine N. Apuzzo, Parvathi M. Devarakonda, Jeffrey W. Hunter, David J. Goldhamer

E-cadherin regulates the stability and transcriptional activity of β-catenin in embryonic stem cells
Sinjini Bhattacharyya, Ridim D. Mote, Jacob W. Freimer, Surya Bansi Singh, Sandhya Arumugam, Yadavalli V. Narayana, Raghav Rajan, Deepa Subramanyam

TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
Sushama Sivakumar, Shutao Qi, Ningyan Cheng, Adwait A. Sathe, Mohammed Kanchwala, Ashwani Kumar, Bret M. Evers, Chao Xing, Hongtao Yu

CFTR modulator response measurements in subjects with cystic fibrosis using 2D differentiated nasal epithelia converted into spheroids
Gimano D. Amatngalim, Lisa W. Rodenburg, Bente L. Aalbers, Henriette H. M. Raeven, Ellen M. Aarts, Iris A.L. Silva, Wilco Nijenhuis, Sacha Vrendenbarg, Evelien Kruisselbrink, Jesse E. Brunsveld, Cornelis M. van Drunen, Sabine Michel, Karin M. de Winter-de Groot, Harry G. Heijerman, Lukas C. Kapitein, Magarida D. Amaral, Cornelis K. van der Ent, Jeffrey M. Beekman

Mutations in coral soma and sperm imply lifelong stem cell differentiation
Elora H. López-Nandam, Rebecca Albright, Erik A. Hanson, Elizabeth A. Sheets, Stephen R. Palumbi

Regulation of stem cell identity by miR-200a during spinal cord regeneration
Sarah E. Walker, Keith Z. Sabin, Micah D. Gearhart, Kenta Yamamoto, Karen Echeverri

Major cell types in flat worms from Dagan, et al.

m6A is required for resolving progenitor identity during planarian stem cell differentiation
Yael Dagan, Yarden Yesharim, Ashley R. Bonneau, Schraga Schwartz, Peter W. Reddien, Omri Wurtzel

Parental origin of Gsα inactivation differentially affects bone remodeling in a mouse model of Albright hereditary osteodystrophy
Patrick McMullan, Peter Maye, Qingfen Yang, David W. Rowe, Emily L. Germain-Lee

The role of muscle stem cells and fibro-adipogenic progenitors in female pelvic floor muscle regeneration following birth injury
Francesca Boscolo Sesillo, Varsha Rajesh, Michelle Wong, Pamela Duran, Brittni Baynes, Louise C. Laurent, Karen L. Christman, Alessandra Sacco, Marianna Alperin

Generation of a new six1-null line in Xenopus tropicalis for study of development and congenital disease
Kelsey Coppenrath, Andre L.P. Tavares, Nikko-Ideen Shaidani, Marcin Wlizla, Sally A. Moody, Marko Horb

| Plant development

Auxin and pectin remodeling interplay during rootlet emergence in white lupin
François Jobert, Alexandre Soriano, Laurent Brottier, Célia Casset, Fanchon Divol, Josip Safran, Valérie Lefebvre, Jérôme Pelloux, Stéphanie Robert, Benjamin Péret

Abortion occurs during double fertilisation and ovule development in Paeonia ludlowii
Ting-qiao Chen, Meng-yu Xie, Yu-meng Jiang, Tao Yuan

Supra-physiological levels of Gibberellins/DELLAs alter the patterning, morphology and abundance of root hairs in root tips of A. thaliana seedlings
Iva McCarthy-Suárez

Supra-physiological levels of gibberellins/DELLAs modify the root cell size/number and the root architecture in root tips of A. thaliana seedlings. Connections to the root hair patterning and abundance
Iva McCarthy-Suárez

Importance of cell division angle, position of cell proliferative area, and localization of AN3 in lateral organ morphology
Ayaka Kinoshita, Makiko Naito, Hirokazu Tsukaya

Dynamic Apical-Basal Enrichment of the F-Actin during Cytokinesis in Arabidopsis Cells Embedded in their Tissues
Alexis Lebecq, Aurélie Fangain, Alice Boussaroque, Marie-Cécile Caillaud

TOR kinase controls shoot development by translational regulation of cytokinin catabolic enzymes
Denis Janocha, Anne Pfeiffer, Yihan Dong, Ondřej Novák, Miroslav Strnad, Lyuba A Ryabova, Jan U. Lohmann

DNA METHYLTRANSFERASE 3 (MET3) is regulated by Polycomb Group complex during Arabidopsis endosperm development
Louis Tirot, Pauline E. Jullien

Arabidopsis development from Bresson, et al.

The genetic interaction of REVOLUTA and WRKY53 links plant development, senescence, and immune responses
Justine Bresson, Jasmin Doll, François Vasseur, Mark Stahl, Edda von Roepenack-Lahaye, Joachim Kilian, Bettina Stadelhofer, James M. Kremer, Dagmar Kolb, Stephan Wenkel, Ulrike Zentgraf

| Evo-devo

Mosaic cis-regulatory evolution drives transcriptional partitioning of HERVH endogenous retrovirus in the human embryo
Thomas A. Carter, Manvendra Singh, Gabrijela Dumbović, Jason D. Chobirko, John L. Rinn, Cédric Feschotte

Trans-generational effect of protein restricted diet on adult body and wing size of Drosophila melanogaster
Sudhakar Krittika, Pankaj Yadav

The influence of adaptation to life at high-altitude on condition dependent sexual shape and size dimorphism in Drosophila melanogaster
Maria Pesevski, Ian Dworkin

Evolution of a chordate-specific mechanism for myoblast fusion
Haifeng Zhang, Renjie Shang, Kwantae Kim, Wei Zheng, Christopher J. Johnson, Lei Sun, Xiang Niu, Liang Liu, Theodore A. Uyeno, Jingqi Zhou, Lingshu Liu, Jimin Pei, Skye D. Fissette, Stephen A. Green, Sukhada P. Samudra, Junfei Wen, Jianli Zhang, Jonathan Eggenschwiler, Doug Menke, Marianne E. Bronner, Nick V. Grishin, Weiming Li, Kaixiong Ye, Yang Zhang, Alberto Stolfi, Pengpeng Bi

Comparing mice and zebrafish tissues from Matsubara, et al.

Comparative analysis of transcriptomic profiles among ascidians, zebrafish, and mice: insights from tissue-specific gene expression
Shin Matsubara, Tomohiro Osugi, Akira Shiraishi, Azumi Wada, Honoo Satake

Symmetry and simplicity spontaneously emerge from the algorithmic nature of evolution
Iain G Johnston, Kamaludin Dingle, Sam F. Greenbury, Chico Q. Camargo, Jonathan P. K. Doye, Sebastian E. Ahnert, Ard A. Louis

Cell Biology

Morphology of brown alga from Charrier, et al.

Growth and immunolocalisation of the brown alga Ectocarpus in a microfluidic environment
Bénédicte Charrier, Samuel Boscq, Bradley J. Nelson, Nino F. Läubli

Distinct mitochondrial remodeling during early cardiomyocyte development in a human-based stem cell model
Sepideh Mostafavi, Novin Balafkan, Ina Katrine Nitschke Pettersen, Gonzalo S. Nido, Richard Siller, Charalampos Tzoulis, Gareth Sullivan, Laurence A. Bindoff

SPE-51, a sperm secreted protein with an Immunoglobulin-like domain, is required for sperm-egg fusion in C. elegans
Xue Mei, Marina Druzhinina, Sunny Dharia, Amber R. Krauchunas, Julie Ni, Gunasekaran Singaravelu, Sam Guoping Gu, Diane C. Shakes, Barth D. Grant, Andrew W. Singson

Female meiosis II and pronuclear fusion require Bicaudal-D
Paula Vazquez-Pianzola, Dirk Beuchle, Gabriella Saro, Greco Hernández, Giovanna Maldonado, Dominique Brunßen, Peter Meister, Beat Suter

Impact of cilia-related genes on mitochondrial dynamics during Drosophila spermatogenesis
Elisabeth Bauerly, Takuya Akiyama, Kexi Yi, Matthew C. Gibson

Clonal dynamics of normal hepatocyte expansions in homeostatic human livers and their association with the biliary epithelium
AM Passman, MJ Haughey, E Carlotti, MJ Williams, B Cereser, ML Lin, S Devkumar, JP Gabrield, FP Russo, M Hoare, J Chin-Aleong, M Jansen, NA Wright, HM Kocher, W Huang, MR Alison, SAC McDonald

Placental mitochondrial function, nutrient transporters, metabolic signalling and steroid metabolism relate to fetal size and sex in mice
Esteban Salazar-Petres, Daniela Pereira Carvalho, Jorge Lopez-Tello, Amanda Nancy Sferruzzi-Perri

Tensin3 interaction with talin drives formation of fibronectin-associated fibrillar adhesions
Paul Atherton, Rafaella Konstantinou, Suat Peng Neo, Emily Wang, Eleonora Balloi, Marina Ptushkina, Hayley Bennett, Kath Clark, Jayantha Gunaratne, David Critchley, Igor Barsukov, Edward Manser, Christoph Ballestrem

Mouse colon sections from Grey, et al.

The epithelial-specific ER stress sensor IRE1β enables host-microbiota crosstalk to affect colon goblet cell development
Michael J. Grey, Heidi De Luca, Doyle V. Ward, Irini A. M. Kreulen, Sage E. Foley, Jay R. Thiagarajah, Beth A. McCormick, Jerrold R. Turner, Wayne I. Lencer

Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans
Ian F. Price, Hannah L. Hertz, Benjamin Pastore, Jillian Wagner, Wen Tang

Tissue-specific heteroplasmy dynamics is accompanied by a sharp drop in mtDNA copy number during development
Nikita Tsyba, Maulik R Patel

Modelling

A coupled mechano-biochemical framework for root meristem morphogenesis
Marco Marconi, Marçal Gallemi, Eva Benková, Krzysztof Wabnik

Viscoelastic Parameterization of Human Skin Cells to Characterize Material Behavior at Multiple Timescales
Cameron H. Parvini, Alexander X. Cartagena-Rivera, Santiago D. Solares

Biological action at a distance: Correlated pattern formation in adjacent tessellation domains without communication
John M. Brooke, Sebastian S. James, Alejandro Jimenez-Rodriguez, Stuart P. Wilson

Modeling the mechanics of growing epithelia with a bilayer plate theory
Joseph Ackermann, Paul-Qiuyang Qu, Loïc LeGoff, Martine Ben Amar

Modelling with Snowflake yeast and Volvocine algae from Day, et al.

Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law
Thomas C. Day, Stephanie S. Höhn, Seyed A. Zamani-Dahaj, David Yanni, Anthony Burnetti, Jennifer Pentz, Aurelia R. Honerkamp-Smith, Hugo Wioland, Hannah R. Sleath, William C. Ratcliff, Raymond E. Goldstein, Peter J. Yunker

Collective Mechanical Responses of Cadherin-Based Adhesive Junctions as Predicted by Simulations
Brandon L. Neel, Collin R. Nisler, Sanket Walujkar, Raul Araya-Secchi, Marcos Sotomayor

Elastic versus Brittle Mechanical Responses Predicted for Dimeric Cadherin Complexes
Brandon L. Neel, Collin R. Nisler, Sanket Walujkar, Raul Araya-Secchi, Marcos Sotomayor

Short-term stimulation of collective cell migration in tissues reprograms long-term supracellular dynamics
Abraham E. Wolf, Matthew A. Heinrich, Isaac B. Breinyn, Tom J. Zajdel, Daniel J. Cohen

Close to optimal cell sensing ensures the robustness of tissue differentiation process: the avian photoreceptor mosaic case
Arnab Barua, Alireza Beygi, Haralampos Hatzikirou

Novel Generic Models for Differentiating Stem Cells Reveal Oscillatory Mechanisms
Saeed Farjami, Karen Camargo Sosa, Jonathan H.P. Dawes, Robert N. Kelsh, Andrea Rocco

A topological look into the evolution of developmental programs
Somya Mani, Tsvi Tlusty

Longitudinal Correlation Analysis for Decoding Multi-Modal Brain Development
Qingyu Zhao, Ehsan Adeli, Kilian M. Pohl

NANOG/GATA6 Interactions Revisited: A Statistical Mechanics Approach towards Cell Fate Decisions
Simon Schardt, Sabine C. Fischer

Pattern Detection on Glioblastoma’s Waddington landscape via Generative Adversarial Networks
Abicumaran Uthamacumaran

Tissue can generate propagating long-range forces on weakly adhesive substrate
Yuting Lou, Takumi Kawaue, Ivan Yow, Yusuke Toyama, Jacques Prost, Tetsuya Hiraiwa

Modelling lumen formation from Torres-Sánchez, et al.

Tissue hydraulics: physics of lumen formation and interaction
Alejandro Torres-Sánchez, Max Kerr Winter, Guillaume Salbreux

Reviews

Physiological, Epigenetic, and Genetic Regulation of Vegetative Phase Change and Rejuvenation in Plants
Tajbir Raihan , Robert L. Geneve , Sharyn E. Perry , Carlos M. Rodriguez Lopez *

Tools & Resources

Engineering functional human gastrointestinal organoid tissues using the three primary germ layers separately derived from pluripotent stem cells
Alexandra K. Eicher, Daniel O. Kechele, Nambirajan Sundaram, H. Matthew Berns, Holly M. Poling, Lauren E. Haines, J. Guillermo Sanchez, Keishi Kishimoto, Mansa Krishnamurthy, Lu Han, Aaron M. Zorn, Michael A. Helmrath, James M. Wells

The Tabula Sapiens: a single cell transcriptomic atlas of multiple organs from individual human donors
The Tabula Sapiens Consortium, Stephen R Quake

C. elegans intestinal brush border from Bidaud-Meynard, et al.

High resolution dynamic mapping of the C. elegans intestinal brush border
Aurélien Bidaud-Meynard, Flora Demouchy, Ophélie Nicolle, Anne Pacquelet, Shashi Kumar Suman, Camille Plancke, François Robin, Grégoire Michaux

CLARA: A web portal for interactive exploration of the cardiovascular cellular landscape in health and disease
Malathi S.I. Dona, Ian Hsu, Thushara S. Rathnayake, Gabriella E. Farrugia, Taylah L. Gaynor, Malvika Kharbanda, Daniel A. Skelly, Alexander R. Pinto

ACORBA: Automated workflow to measure Arabidopsis thaliana root tip angle dynamic
Nelson BC Serre, Matyas Fendrych

Induction of human trophoblast stem-like cells from primed pluripotent stem cells
Yu Jin Jang, Mijeong Kim, Bum-Kyu Lee, Jonghwan Kim

CellProfiler 4: Improvements in Speed, Utility and Usability
David R. Stirling, Madison J. Swain-Bowden, Alice M. Lucas, Anne E. Carpenter, Beth A. Cimini, Allen Goodman

De novo spatiotemporal modelling of cell-type signatures identifies novel cell populations in the developmental human heart
Sergio Marco Salas, Xiao Yuan, Christer Sylven, Mats Nilsson, Carolina Wählby, Gabriele Partel

Hnf1b-CreER causes efficient recombination of a Rosa26-RFP reporter in duct and islet δ cells
Meritxell Rovira, Miguel Angel Maestro, Vanessa Grau, Jorge Ferrer

Knock-in tagging in zebrafish facilitated by insertion into non-coding regions
Daniel S. Levic, Naoya Yamaguchi, Siyao Wang, Holger Knaut, Michel Bagnat

Highly efficient synthetic CRISPR RNA/Cas9-based mutagenesis for cardiovascular phenotypic screening in F0 zebrafish
Rachael E. Quick, Sweta Parab, Zane R. Tolbert, Ryota L. Matsuoka

From heterogenous morphogenetic fields to homogeneous regions as a step towards understanding complex tissue dynamics
Satoshi Yamashita, Boris Guirao, François Graner

Segmenting a diverse collection of cells and tissues from Baumgartner, et al.

PECAn, a pipeline for image processing and statistical analysis of complex mosaic 3D tissues
Michael E. Baumgartner, Paul F. Langton, Alex Mastrogiannopoulos, Remi Logeay, Eugenia Piddini

Rapid generation of homozygous fluorescent knock-in human cells using CRISPR/Cas9 genome editing and validation by automated imaging and digital PCR screening
Moritz Kueblbeck, Andrea Callegari, Beatriz Serrano-Solano, Jan Ellenberg

A genetic toolkit for studying transposon control in the Drosophila melanogaster ovary
Mostafa F. ElMaghraby, Laszlo Tirian, Kirsten-André Senti, Katharina Meixner, Julius Brennecke

An open-access volume electron microscopy atlas of whole cells and tissues
C. Shan Xu, Song Pang, Gleb Shtengel, Andreas Müller, Alex T. Ritter, Huxley K. Hoffman, Shin-ya Takemura, Zhiyuan Lu, H. Amalia Pasolli, Nirmala Iyer, Jeeyun Chung, Davis Bennett, Aubrey V. Weigel, Melanie Freeman, Schuyler B. van Engelenburg, Tobias C. Walther, Robert V. Farese Jr., Jennifer Lippincott-Schwartz, Ira Mellman, Michele Solimena, Harald F. Hess

A Comprehensive Overview of the Physical Health of the Adolescent Brain Cognitive Development Study (ABCD) Cohort at Baseline
Clare E. Palmer, Chandni Sheth, Andrew T. Marshall, Shana Adise, Fiona C. Baker, Linda Chang, Duncan B. Clark, Rada K. Dagher, Gayathri J. Dowling, Marybel R. Gonzalez, Frank Haist, Megan M. Herting, Rebekah S. Huber, Terry L. Jernigan, Kimberly LeBlanc, Karen Lee, Krista M. Lisdahl, Gretchen Neigh, Megan W. Patterson, Perry Renshaw, Kyung E. Rhee, Susan Tapert, Wesley K. Thompson, Kristina Uban, Elizabeth R. Sowell, Deborah Yurgelun-Todd

Collateral damage: Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme
Morag A. Lewis, Neil J. Ingham, Jing Chen, Selina Pearson, Francesca Di Domenico, Sohinder Rekhi, Rochelle Allen, Matthew Drake, Annelore Willaert, Victoria Rook, Johanna Pass, Thomas Keane, David Adams, Abigail S. Tucker, Jacqueline K. White, Karen P. Steel

The generation of a Bcl11a lineage tracing mouse model
Sara Pensa, Pentao Liu, Walid T. Khaled

Assessing donor-to-donor variability in human intestinal organoid cultures
Sina Mohammadi, Carolina Morell-Perez, Charles W. Wright, Thomas P. Wyche, Cory H. White, Theodore R. Sana, Linda A. Lieberman

Imaging duckweed growth from Cox Jr., et al.

Automated imaging of duckweed growth and development
Kevin L. Cox Jr., Jordan Manchego, Blake C. Meyers, Kirk J. Czymmek, Alex Harkess

Placental gene expression-based cell type deconvolution: Cell proportions drive preeclampsia gene expression differences
Kyle A Campbell, Justin A Colacino, Muraly Puttabyatappa, John F Dou, Elana R Elkin, Saher S Hammoud, Steven E Domino, Dana C Dolinoy, Jaclyn M Goodrich, Rita Loch-Caruso, Vasantha Padmanabhan V, Kelly M Bakulski

Endogenous protein tagging in medaka using a simplified CRISPR/Cas9 knock-in approach
Ali Seleit, Alexander Aulehla, Alexandre Paix

IBEX: An open and extensible method for high content multiplex imaging of diverse tissues
Andrea J. Radtke, Colin J. Chu, Ziv Yaniv, Li Yao, James Marr, Rebecca T. Beuschel, Hiroshi Ichise, Anita Gola, Juraj Kabat, Bradley Lowekamp, Emily Speranza, Joshua Croteau, Nishant Thakur, Danny Jonigk, Jeremy Davis, Jonathan M. Hernandez, Ronald N. Germain

Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging
John W. Hickey, Elizabeth K. Neumann, Andrea J. Radtke, Jeannie M. Camarillo, Rebecca T. Beuschel, Alexandre Albanese, Elizabeth McDonough, Julia Hatler, Anne E. Wiblin, Jeremy Fisher, Josh Croteau, Eliza C. Small, Anup Sood, Richard M. Caprioli, R. Michael Angelo, Garry P. Nolan, Kwanghun Chung, Stephen M. Hewitt, Ronald N. Germain, Jeffrey M. Spraggins, Emma Lundberg, Michael P. Snyder, Neil L. Kelleher, Sinem K. Saka

Research practice & education

Virtual meetings promise to eliminate the geographical and administrative barriers and increase accessibility, diversity, and inclusivity
Juncheng Wu, Anushka Rajesh, Yu-Ning Huang, Karishma Chhugani, Rajesh Acharya, Kerui Peng, Ruth D. Johnson, Andrada Fiscutean, Carla Daniela Robles-Espinoza, Francisco M. De La Vega, Riyue Bao, Serghei Mangul

Transparency in peer review: Exploring the content and tone of reviewers’ confidential comments to editors
Bridget C. O’Brien, Anthony R. Artino Jr., Joseph A. Costello, Erik Driessen, Lauren A. Maggio




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