PhD candidates in quantitative developmental biology at Leiden University
Posted by rmerks, on 8 January 2020
Closing Date: 15 March 2021
PhD candidates on Quantitative Developmental Biology and Mathematical Modeling of Blood Vessel Growth near Tumors at Leiden University, The Netherlands
Key responsibilities
The PhD projects will be part of an interdisciplinary project that will unravel how modifications of the extracellular matrix, as they can occur for example near tumors, can modify the structure of new blood vessel networks.
In this highly interdisciplinary project experimental biologists will work closely together with mathematical modelers on a daily basis. This approach enables the incremental development and testing of theories of single-cell behavior and collective cell behavior during tumor angiogenesis.
Based on cycles of iterative refinement of the mathematical model, followed by experimental validation, you will unravel aspects of blood vessel growth, and prepare your insights for publication in the biological, biophysical, and/or biomathematical literature.
One mathematical modeling project will focus primarily on the cellular scale and on the molecular mechanisms of mechanical cell-cell interactions. The second mathematical modeling project will focus on collective cell behavior, initially simplifying the underlying molecular details. The experimental project will focus on imaging single cell behavior and collective cell behavior during angiogenesis.
Our interdisciplinary team carries out mathematical biology research in close interaction with our recently established experimental lab. More information about the group can be found here. This interdisciplinary group is embedded at the Mathematical Institute and the Institute of Biology Leiden, both at the Faculty of Science at Leiden University, and is physically based at, and embedded within the Cell Observatory of the Faculty of Science.
For more details about the positions and application procedure, see:
For the mathematical modeling positions: https://www.universiteitleiden.nl/vacatures/2019/q4/19-594-phd-candidates-on-the-mathematical-modeling-of-blood-vessel-growth-near-tumors
For the experimental position: https://www.universiteitleiden.nl/vacatures/2020/q1/20-018-phd-in-quantitative-cell-and-developmental-biology
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