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PhD position: Chromosome Dynamics During Spermatogenesis in Drosophila, University of Zurich, Switzerland

Posted by , on 19 April 2018

Closing Date: 15 March 2021

We seek candidates interested in completing a PhD thesis within the framework of a research project (46 months) funded by the Swiss National Science Foundation (SNF).

Chromosome reorganization during spermatogenesis is dramatic. Beyond meiosis, it includes chromosome compaction into an elongated sperm nucleus which is accompanied by an almost complete exchange of histones with sperm nuclear basic proteins (SNBPs). Exploiting advantages of the model organism Drosophila melanogaster, our project addresses: (1.) Homolog pairing and chromosome territory formation in spermatocytes and its molecular basis. (2.) Molecular mechanisms maintaining homolog conjunction until metaphase I, as well as Separase-dependent resolution of this conjunction just before anaphase I. (3.) Transformation of the spherical postmeiotic spermatid nucleus into the compact needle shape present in mature sperm. A wide range of methods will be applied (genetics: classic, RNAi, CRISPR/cas, proteomics, time lapse imaging, FISH, immunofluorescence).

Prerequisite for the PhD position is a MSc degree (or equivalent) in biology, biochemistry or related fields. We are looking for a highly motivated individual with a strong background in cell biology, developmental biology, molecular biology, genetics, biochemistry. Experience with Drosophila is beneficial. Successful candidates will join the PhD program in Molecular Life Sciences (MLS) of the Life Science Zurich Graduate School (LSZGS) jointly organized by ETH and University of Zurich (UZH). UZH is an equal opportunity employer.

Application deadline is 31 May 2018. Application documents should include a motivation letter, curriculum vitae and a grade transcript. Applications should be sent electronically as one single file in PDF format to the address below. Additionally, candidates should organize that two to three letters of recommendation are sent to the same address.

Prof. Dr. Christian Lehner, Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. christian.lehner[at]imls.uzh.ch

Additional information: www.imls.uzh.ch/en/research/Lehner.html

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