Post-doc in Paris: Studying Stem Cell Genome Stability using Drosophila Intestinal Stem Cells (Biologists or Bioinformaticians)
Posted by Allison Bardin, on 10 June 2016
Closing Date: 15 March 2021
Maintaining genome integrity of adult stem cells is important to prevent cancer initiation and stem cell functional decline during aging. Our recent work (Siudeja, Cell Stem Cell, 2015) has demonstrated that a surprising level of genome instability arises during aging in adult intestinal stem cells of Drosophila. Mechanistically, this is caused by frequent loss of heterozygosity due to mitotic recombination as well as gene inactivation through deletion and complex chromosome rearrangements leading to tumor suppressor inactivation. This model provides an excellent system in which to address important fundamental questions of how stem cell genomes are maintained. The postdoctoral project will further investigate the causes and consequences of stem cell genome instability using Drosophila genetics and whole-genome sequencing approaches.
We are seeking enthusiastic, collaborative, and highly motivated post-doctoral candidates with good Ph.D. track records. Both biologists and bioinformaticians are welcome to apply. Experience in genetics and/or whole-genome NGS sequencing analysis would be appreciated.
Our team is situated within a new, dynamic, international department with state-of-the-art imaging, sequencing, and proteomics facilities at the Institut Curie in the heart of downtown Paris. To apply, please send your CV, cover letter, and names of two references to allison.bardin@curie.fr.
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