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Post-doctoral position available: Neural crest development in Xenopus

Posted by , on 20 November 2012

Closing Date: 15 March 2021

SCHOOL OF BIOLOGICAL SCIENCES, UNIVERSITY OF EAST ANGLIA

 

POST DOCTORAL RESEARCH ASSOCIATE POSITION AVAILABLE

 

Neural Crest Development in Xenopus

 

£30,122 to £35,938 per annum

 

A Post Doctoral Research Associate position to investigate the Regulation of Neural Crest development by transcriptional pausing is available in the lab of Dr. Grant Wheeler, School of Biological Sciences, University of East Anglia.

 

The neural crest (NC) is a multipotent stem cell-like population that migrates and differentiates into many cell types within the developing embryo. The drug Leflunomide has been identified by ourselves in collaboration with others, as inhibiting neural crest development in Xenopus embryos as well as inhibiting melanoma growth in mouse xenograft assays (White et al. 2011). Leflunomide is proposed to act by blocking elongation during RNA polymerase II mediated transcription. Transcriptional pausing and elongation have recently been implicated in regulating stem cell differentiation and have been shown to be dependent upon chromatin modification. This project will expand upon these results to further understand the role of transcriptional pausing and elongation in regulating Neural Crest development. The work will be carried out in the lab of Dr. Grant Wheeler (grant.wheeler@uea.ac.uk).

 

White RM, Cech J, Ratanasirintrawoot S, Lin CY, Rahl PB, Burke CJ, Langdon E, Tomlinson ML, Mosher J, Kaufman C, Chen F, Long HK, Kramer M, Datta S, Neuberg D, Granter S, Young RA, Morrison S, Wheeler GN, Zon LI. (2011) DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature. 471:518-22

 

You must have a PhD or equivalent qualification in molecular developmental biology and fulfil elements of the person specification. This full time post is available from 1 February 2013 and is available for at least 21 months.

 

Closing date: 12 noon on 18 December 2012.

 

Further particulars and an application form are available on our website: www.uea.ac.uk/hr/jobs/ or Tel. 01603 593493 (Ref: RA900)




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