ROLE of THYROID HORMONE in MOUSE INTESTINAL DEVELOPMENT and REGENERATION.
Thyroid hormone (T3) is known to be critical for postembryonic development in mammals (around birth). This laboratory has been taking a multi-faceted approach to investigate the function of T3 and T3 receptors (TRs) in vivo by using Xenopus and mouse as models. A major recent focus is on how T3 regulates adult stem cell function during mouse postembryonic intestinal maturation and regeneration. We have shown earlier that System L amino acid transporter can influence gene regulation by TR through cellular uptake of T3 in a cell line and frog occytes. In addition, the TR coactivator PRMT1 is upregulated during mouse intestinal maturation. Yun-Bo Shi is recruiting two postdoctoral fellows to use knockout mice to study whether they play a role in the function of T3 in the intestinal maturation and regeneration.
- Ritchie, J.W.A., Shi, Y.-B. , Hayashi, Y., Baird, F.E., Muchekehu, R.W., Christie, G.R., and Taylor, P.M. (2003). A role for thyroid hormone transporters in transcriptional regulation by thyroid hormone receptors. Mol. Endocrinol. 17, 653-661.
- Matsuda, H., Paul, B. D., Choi, C. Y., Hasebe, T., and Shi, Y.-B. (2009) Novel functions of protein arginine methyltransferase 1 in thyroid hormone receptor-mediated transcription and in the regulation of metamorphic rate in Xenopus laevis. Mol. Cell. Biol. 29, 745–757.
- Sato, Y., Heimeier, R.A., Li, C., Deng, C., and Shi, Y.-B. (2011) Extracellular domain of CD98hc is required for early murine development. Cell & Bioscience 1:7, 1-12.
- Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y.-B., Taylor, P. M., and Cantrell, D. A. (2013) Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nature Immunology 14, 500-8.
- Poncet, N., Mitchell, F.E., Ibrahim, A.F.M., McGuire, V.A., English, G., Arthur, S.C., and Shi, Y.-B*., and Taylor, P.M*. (2014) The catalytic subunit of the System L1 amino acid transporter (Slc7a5) facilitates nutrient signaling in mouse skeletal muscle. PLoS One 9(2): e89547,1-14.
The positions are open to all candidates within 4 years of MD/PhD degree and with
experience in mouse research. Please contact: YUN-BO SHI at shi@helix.nih.gov,
NICHD/NIH, Bethesda, MD 20892, USA. (http://smm.nichd.nih.gov/)
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