Closing Date: 15 March 2021
ROLE of THYROID HORMONE in MOUSE INTESTINAL DEVELOPMENT and REGENERATION.
Thyroid hormone (T3) is known to be critical for postembryonic development in mammals (around birth). This laboratory has been taking a multi-faceted approach to investigate the function of T3 and T3 receptors (TRs) in vivo by using Xenopus and mouse as models. A major recent focus is on how T3 regulates adult stem cell function during mouse postembryonic intestinal maturation and regeneration. We have shown earlier that System L amino acid transporter can influence gene regulation by TR through cellular uptake of T3 in a cell line and frog occytes. In addition, the TR coactivator PRMT1 is upregulated during mouse intestinal maturation. Yun-Bo Shi is recruiting two postdoctoral fellows to use knockout mice to study whether they play a role in the function of T3 in the intestinal maturation and regeneration.
- Ritchie, J.W.A., Shi, Y.-B. , Hayashi, Y., Baird, F.E., Muchekehu, R.W., Christie, G.R., and Taylor, P.M. (2003). A role for thyroid hormone transporters in transcriptional regulation by thyroid hormone receptors. Mol. Endocrinol. 17, 653-661.
- Matsuda, H., Paul, B. D., Choi, C. Y., Hasebe, T., and Shi, Y.-B. (2009) Novel functions of protein arginine methyltransferase 1 in thyroid hormone receptor-mediated transcription and in the regulation of metamorphic rate in Xenopus laevis. Mol. Cell. Biol. 29, 745–757.
- Sato, Y., Heimeier, R.A., Li, C., Deng, C., and Shi, Y.-B. (2011) Extracellular domain of CD98hc is required for early murine development. Cell & Bioscience 1:7, 1-12.
- Sinclair, L. V., Rolf, J., Emslie, E., Shi, Y.-B., Taylor, P. M., and Cantrell, D. A. (2013) Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nature Immunology 14, 500-8.
- Poncet, N., Mitchell, F.E., Ibrahim, A.F.M., McGuire, V.A., English, G., Arthur, S.C., and Shi, Y.-B*., and Taylor, P.M*. (2014) The catalytic subunit of the System L1 amino acid transporter (Slc7a5) facilitates nutrient signaling in mouse skeletal muscle. PLoS One 9(2): e89547,1-14.
The positions are open to all candidates within 4 years of MD/PhD degree and with
experience in mouse research. Please contact: YUN-BO SHI at firstname.lastname@example.org,
NICHD/NIH, Bethesda, MD 20892, USA. (http://smm.nichd.nih.gov/)