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Monotreme ears and the evolution of mammal jaws

Posted by on August 5th, 2020

Jaw joints, in most vertebrate animals that have them, form between a bone in the head called the quadrate and one in the mandible called the articular. The mandibles (lower jaw bone) of most vertebrates is compound, made up of fused bones, but we mammals are different.  We have lots of different types of teeth[…]

Catch Me if You Can: An elusive underpinning for Arx(GCG)10+7-mediated apoptosis in X-linked infantile spasms syndrome

Posted by on June 3rd, 2020

This post highlights the approach and finding of a new research article published by Disease Models and Mechanisms (DMM). This feature is written by Olivia Howell as apart of a seminar at The University of Alabama (taught by DMM Editorial Board member, Prof. Guy Caldwell) on current topics related to use of animal and cellular[…]

The people behind the papers – Charles Sheehan, John McMahon and Debby Silver

Posted by on May 27th, 2020

This interview, the 76th in our series, was published in Development earlier this year.  Interneurons are crucial to cortical function and their dysregulation has been implicated in various neurological pathologies, yet how they are generated during development is still poorly understood. A new paper in Development investigates interneuron neurogenesis in the mouse embryo and its[…]

Zipping up the neural tube

Posted by on April 21st, 2020

Matteo A. Molè & Andrew J. Copp Molè et al., Integrin-Mediated Focal Anchorage Drives Epithelial Zippering during Mouse Neural Tube Closure. Dev. Cell. 52, 321-334.e6 (2020). Zippering is a striking phenomenon whereby two opposing epithelial tissues become progressively united in one direction over a period of time. Similar, to the travel of a zip fastener,[…]

POSTDOCTORAL RESEARCHER

Posted by on February 27th, 2020

Kuure lab, affiliated with STEMM research program at Research Programs Unit of the Faculty of Medicine and Helsinki Institute of Life Science (HiLIFE), University of Helsinki, invites applications for a position of POSTDOCTORAL RESEARCHER IN FinnDisMice PROJECT for a two-year fixed term position (possibility for extension) starting as soon as possible. Trial period of six[…]

The people behind the papers – Roman Szabo and Thomas Bugge

Posted by on January 29th, 2020

This interview, the 74th in our series, was recently published in Development.  Dysregulated activity of cell surface proteolytic enzymes has a wide range of developmental and pathological consequences, but the underlying mechanisms are often poorly understood. A new Development paper uses mice to model a severe inherited form of enteropathy and the role of the serine protease matriptase[…]

BSDB Gurdon/The Company of Biologists 2019 Summer Studentship Report – Nivetha Manobharath

Posted by on January 20th, 2020

Established by the British Society for Developmental Biology in 2014, The Gurdon/The Company of Biologists Summer Studentship scheme provides financial support to allow highly motivated undergraduate students an opportunity to engage in practical research during their summer vacation. Each year, ten successful applicants spend eight weeks in the research laboratories of their choices, and the feedback[…]

The people behind the papers – Ding Li and Jianbo Wang

Posted by on November 29th, 2019

This interview, the 72nd in our series, was recently published in Development.  Heart development in mammals is a beautifully complex process. Patterning, proliferation and differentiation are all coordinated with cell movements and tissue morphogenesis (for instance elongation, fusion, folding, looping). However, our knowledge of the molecular regulators of heart development currently outstrips what we know about the[…]

Secret talk between epithelium and endothelium determines hair follicle stem cell fate

Posted by on November 6th, 2019

By Kefei Nina Li and Prachi Jain   Stem cells are typically defined by their ability to self-renew and differentiate. These activities are tightly controlled by both intrinsic cues and extrinsic cues from the microenvironment, known as the SC niche. This niche consists of multiple components, among which blood vessels (BVs) are critical as they[…]

Postdoctoral position in Quantitative Live Imaging of Cell Fate Choice and Organization

Posted by on October 16th, 2019

The Posfai Lab at Princeton University (www.Posfailab.org) is looking to recruit a highly motivated postdoctoral fellow to study the molecular and cellular mechanisms of cell fate choice and emergent organization during early embryonic development, using the preimplantation mouse embryo as a model system. The project will combine genetic engineering and quantitative, high-resolution live imaging using[…]