A postdoctoral position is immediately available for highly motivated recent PhD or MD/PhD graduates in the Singh Lab (https://medicine.vumc.org/person/bhuminder-singh-phd) at the Division of Gastroenterology, Hepatology, and Nutrition at Vanderbilt University Medical Center to participate in basic studies controlling epithelial polarity as well as more translational efforts to develop innovative therapeutic approaches for colorectal cancer (CRC).
Available projects include:
• Regulation of EGFR signaling by polarized trafficking of its ligand epiregulin (EREG) and mechanisms underlying transformation upon apical mistrafficking of EREG;
• Role of receptor tyrosine kinases MET and RON in resistance to EGFR-targeted therapeutics in CRC.
The projects will involve 3D cultures of genetically or pharmacologically manipulated cell lines and CRC organoids and in vivo cancer xenografts. The effects of specific stimuli and contribution of individual molecules will be monitored by live or fixed (confocal) microscopy, cellular signaling, phenotypic assays, multiplex fluorescence imaging, and comparative RNA-seq (single-cell or bulk) or proteomic analysis. Please see recent publications at: https://scholar.google.com/citations?user=Z9Wjl6AAAAAJ&hl=en
Candidates are sought with experience in signal transduction, biochemistry, cell biology, or cancer biology. Individuals are expected to have excellent oral and written communication skills, as well as a track record of productivity.
Please send a CV, a cover letter, and names of three references to Dr. Bhuminder Singh: email@example.com. The position is available immediately.