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Postdoctoral position to study cardiovascular development

Posted by , on 31 October 2017

Closing Date: 15 March 2021

A postdoctoral position is available in the laboratory of Dr. Sophie Astrof at Thomas Jefferson University to study roles of cell-extracellular matrix (ECM) interactions in cardiovascular development and congenital heart disease. We have recently discovered that progenitors within the second heart field (SHF) give rise to endothelial cells composing pharyngeal arch arteries. Projects in the lab focus on the role of ECM in regulating cell fate and migration of SHF-derived cells, and in the regulation of signaling between endoderm-, mesoderm-, and ectoderm-derived tissues during the morphogenesis of the pharyngeal vasculature. The project will combine genetic manipulation, embryology, cell biology, and confocal imaging. My laboratory is a part of a modern and well-equipped Center for Translational Medicine at Jefferson Medical College (http://www.jefferson.edu/university/research/researcher/researcher-faculty/astrof-laboratory.html) located in the heart of Philadelphia. For further information on our work, please see the following publications: Wang et al., Development, 143:88-100, 2016 and Wang et al, Developmental Biology 421:108-217, 2017. To apply, please send a letter of interest detailing your expertise, CV and names and contact information of three references to sophie.astrof@gmail.com




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