Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints.

The preprints this month are hosted on bioRxiv – use these links below to get to the section you want:

Developmental biology

• Patterning & signalling
• Morphogenesis & mechanics
• Genes & genomes
• Stem cells, regeneration & disease modelling
• Plant development
• Environment, evolution and development

Cell Biology

Modelling

Tools & Resources

Research practice and education

Developmental biology

| Patterning & signalling

Tissue-wide, synchronous Erk oscillations time the segmentation of the zebrafish notochord

Priyom Adhyapok, James Norman, Michel Bagnat, Stefano Di Talia

Cellular NAD+ availability and redox state constrain developmental speed in the Drosophila eye

Nisha Veits, Yuting Guo, Jingjing He, Khalil Mazouni, Ivan Nemazanyy, Martin Bres, Cara Picciotto, Claire Mestdagh, Yan Yan, Francois Schweisguth

Cytoneme feedback ensures signaling specificity when multiple ligands converge on a common receptor

Akshay Patel, Molly Maranto, Hind Hitti, Sougata Roy

EBF1 regulates sensory establishment in the cochlea by positioning the medial boundary of the prosensory domain and restricting proliferation of the sensory progenitor population

Kathryn G. Powers, Joshua Hahn, Juliette Wohlschlegel, Olivia Bermingham-McDonogh

Morphogen-guided neocortical organoids recapitulate regional areal identity and model neurodevelopmental disorder pathology

Yuan-Chen Tsai, Hajime Ozaki, Xinyi Wang, Axel A. Almet, Isabel Fleming, Kaori Shiraiwa, Matthew Jung Min Noh, Caihao Nie, Sunnyana Trejo, Bret Kiyoshi Sugita, Jiya Dalal, Ruben Alberto Gonzalez, Briana De Jesus, Gregory Li-Min Chen, Michael J Gandal, Qing Nie, Momoko Watanabe

Rewired gene interactions during development of serially homologous appendages in male and female Drosophila

Amber M. Ridgway, Javier Figueras Jimenez, Beñat Yáñez Iturbe-Ormaeche, Maria D. S. Nunes, Alistair P. McGregor

Ectomesenchymal identity emerges via relief of Twist1 transcript destabilization

Lara C. Busby, Jessica R. Patrick, Luke W. Lyons, Megan L. Martik

Spatiotemporal proteomics reveals dynamic antagonistic gradients shaping signalling waves

Wilke H. M. Meijer, Virginia Andrade, Suzan Stelloo, Wouter M. Thomas, Marek J. van Oostrom, Eveline F. Ilcken, Kim T. J. Peters, Michiel Vermeulen, Katharina F. Sonnen

Bruce suppresses autophagy-regulated caspase activity and wing tissue growth in Drosophila

Natsuki Shinoda, Yutaro Hama, Nozomi Hanawa, Masayuki Miura

Vnd and En are expressed in orthogonal stripes and act in a brief competence window to combinatorially specify NB7-1 and its early lineage

Nathan Anderson, Sen-Lin Lai, Chris Q. Doe

Bendless-mediated K63 ubiquitination modulates cellular signalling to regulate Drosophila hematopoiesis

Asfa Kamal, Yash Sheregare, Chaitanya Patkar, Mrunmayi Markam, Rujul Deolikar, Nawaneetan Sriraman, Aditya Seth, Manish Jaiswal, Rohan Jayant Khadilkar

Notch coordinates self-organization of germ layers and axial polarity in cnidarian gastruloids

Sanjay Narayanaswamy, Franziska Haas, Emmanuel Haillot, Elly Tanaka, Ulrich Technau

The protein-tyrosine phosphatase Shp2 is essential for lymphatic endothelial cell differentiation in zebrafish

Daniëlle T.J. Woutersen, Andreas van Impel, Stefan Schulte-Merker, Jeroen den Hertog

A hormonally regulated gating mechanism controls EMT timing to ensure progenitor cell specification occurs prior to epithelial breakdown

Andrew T Plygawko, Jamie Adams, Zack Richards, Kyra Campbell

Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg-mediated lipid metabolism

Giacomo Furlan, S. Bryn Martin, Brandon Cho, Sarah A. McClymont, Elizabeth J. Robertson, Evelyne Collignon, Miguel Ramalho-Santos

Spatio-temporal control of myoblast identity drives muscle diversity in the Drosophila leg

Camille Guillermin, Violaine Tribollet, Mathilde Bouchet, Anne Laurencon, Dan Zhou, Sergio Sarnataro, Laurent Gilquin, Isabelle Stevant, Guillaume Marcy, Emeric Texeraud, Yad Ghavi-Helm, Benjamin Gillet, Sandrine Hughes, Samantha Vonau, Jonathan Enriquez

Rac1 inhibition slows down the segmentation clock and increases the somite size

Maria Pappa, Charisios D. Tsiairis

A systemic role of macrophage-derived BMP2/4 homolog Dpp in regulating sterol hormone synthesis under dietary stress

Sergio Juarez-Carreño, Marco Milán

Gene network switching provides a mechanistic basis for time-to-space translation in insect embryonic patterning

Mahla Ahmadi, Heike Rudolf, Christine Mau, Jimena Garcia-Guillen, Ezzat El-Sherif

Endothelial Slit2 guides the Robo1-positive sympathetic innervation during heart development

Juanjuan Zhao, Susann Bruche, Konstantinos Lekkos, Carolyn Carr, Joaquim M. Vieira, John G. Parnavelas, William D. Andrews, Mathilda T.M. Mommersteeg

Uncoupling Neocortical Neuron Fate and Migration via a Let-7–RBX2 Axis

Steven Decker, Keiko Hino, Anna La Torre, Sergi Simó

Canonical WNT signalling governs Echinococcus metacestode development

Ruth Herrmann, Luisa Schiegl, Michaela Herz, Kilian Rudolf, Akito Koike, Markus Spiliotis, Monika Bergmann, Nancy Holroyd, Uriel Koziol, Matt Berriman, Klaus Brehm

Vascular Patterning affects Intramembranous Ossification through HIF1α-Vegf Signaling

Soma Dash, Jonathan R. Rettig, Madelaine Gogol, Paul A. Trainor

Morphogen and juxtacrine signalling dynamically integrate to specify cell fates with single-cell resolution

Alicia Donoghue, Lewis S Mosby, Inês Lago Baldaia, Tamara Hodgetts, Evelina Ursu, Zeynep Erten, Zena Hadjivasiliou, Vilaiwan M Fernandes

Gli3R-mediated inhibition of hedgehog signaling alters the embryonic transcriptome in zebrafish

Anna J. Moyer, Summer B. Thyme

Integrated ERK, PKA, YAP/TAZ, and SHH Signaling Drives Cortical Lineage Diversification and Evolutionary Expansion

Zhuangzhi Zhang, Zhejun Xu, Tongye Fu,Jialin Li, Feihong Yang, Chuannan Yang, Wenhui Zheng, Zizhuo Sha, Yanjing Gao, Mengge Sun, Zhenmeiyu Li, Jing Ding, Xiaosu Li, Zhengang Yang

The Wnt co-receptor Arrow-LRP5/6 is required for Planar Cell Polarity establishment in Drosophila

Ursula Weber, Reza Farhadifar, Marek Mlodzik

Cardiomyocyte-expressed TGFβ signals to fibroblasts to program early heart maturation and adult myocyte identity

Rachel A. Minerath, Rajesh K. Kasam, Casey O. Swoboda, Vikram Prasad, Kelly M. Grimes, N. Scott Blair, Hadi Khalil, Christina M Alfieri, Logan Eads, Anthony J. Saviola, Mohamad Azhar, Lianjie Miao, Mingfu Wu, Michelle Tallquist, Kirk C. Hansen, Matthew T Weirauch, Katherine E. Yutzey, Douglas P. Millay, Jeffery D. Molkentin

Chaperone AIP Couples mTORC1 Activation and Catabolic Metabolism During Neonatal Development

Márta Korbonits, Xian Wang, Sayka Barry, Chung Thong Lim, Oniz Suleyman, Stefano De Tito, Nazia Uddin, Maria Lillina Vignola, Charlotte Hall, Laura Perna, J. Paul Chapple, Gabor Czibik, Sian M Henson, Valle Morales, Katiuscia Bianchi, Viðar Örn Eðvarðsson, Kristján Ari Ragnarsson, Viktoría Eir Kristinsdóttir, Anne Debeer, Yoeri Sleyp, Rena Zinchenko, Glenn Anderson, Michael Duchen, Kritarth Singh, Chih Yao Chung, Yu Yuan, Sandip Patel, Artem O. Borovikov, Hans Tómas Björnsson, Hilde Van Esch, Sharon Tooze, Ezra Aksoy, Caroline Brennan, Oliver Haworth

Arabidopsis epigenetic factor AS2 attenuates nucleolar stress by camptothecin and establishes leaf polarity by repressing a CDK inhibitor

Ayami Nakagawa, Hidekazu Iwakawa, Hiro Takahashi, Simon Vial-Pradel, Mari Takahashi, Kazuomi Ohga, Takuma Ito, Motoki Tamai, Eri Takada, Sumie Keta, Nanako Ishibashi, Sayuri Ando, Iwai Ohbayashi, Masaki Ito, Mami Yamazaki, Byung-Yoon Cha, Je-Tae Woo, Michiko Sasabe, Munetaka Sugiyama, Shoko Kojima, Yasunori Machida, Chiyoko Machida

Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning

Zukai Liu, Chengxiang Qiu, Connor A. Kubo, Stella Xu, Riza M. Daza, Eva Nichols, Wei Yang, Anh Vo, Mary B. O’Neill, Choli Lee, Jay Shendure, Nobuhiko Hamazaki

Regulation of mouse blastocyst primitive endoderm differentiation by p38-mitogen-activated-kinases (p38-MAPKs) is inner-cell-mass (ICM) autonomous and unrelated to cavity expansion defects in ICM specification

Martina Bohuslavová (née Stiborová), Andrea Hauserová, Rebecca Collier, Joaquin Lilao-Garzón, Silvia Muñoz-Descalo, Alexander W. Bruce

Cell autonomous polarization by the planar cell polarity signaling pathway

Alexis T Weiner, Silas Boye Nissen, Kaye Suyama, Bomsoo Cho, Gandhy Pierre-Louis, Jeffrey D Axelrod

E(spl)m4 Directly Antagonizes Traf4 to Inhibit JNK Signaling in Drosophila  Katrin Strobel, Jennifer Falconi, Cédric Leyrat, Rémi Logeay, Sarah J. Bray, Alexandre Djiane

| Morphogenesis & mechanics

Lineage domains and cytoskeletal cables organize a cellular square grid in a crustacean

Beatrice L. Steinert, Leo Blondel, Chandrashekar Kuyyamudi, Evangelia Stamataki, Anastasios Pavlopoulos, Cassandra G. Extavour

Self-organized fingering instabilities drive the emergence of tissue morphogenesis in digit organoids

Rio Tsutsumi, Antoine N. Diez, Steffen Plunder, Ryuichi Kimura, Shinya Oki, Kaori Takizawa, Haruhiko Akiyama, Yusuke Mii, Ritsuko Takada, Shinji Takada, Mototsugu Eiraku

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus

Biophysical mechanisms of morphogenesis in lizard lungs

Kaleb Hill, Aaron H. Griffing, Michael A. Palmer, Bezia Lemma, Aria Lupo, Tony Gamble, Natalia A. Shylo, Andrej Košmrlj, Paul A. Trainor, Celeste M. Nelson

VANGL2 shapes the mouse heart tube from adjacent epithelia and without planar polarity

Paul Palmquist-Gomes, Gaëlle Letort, Ayushi U. Hegde, José María Pérez-Pomares, Sigolène M. Meilhac

LGL-1 and the RhoGAP protein PAC-1 redundantly control polarization of the C. elegans embryonic epidermal epithelium

Olga D. Jarosińska, Amalia Riga, Hala Zahreddine Fahs, Joren M. Woeltjes, Ruben Schmidt, Fathima S. Refai, Suma Gopinadhan, Kristin C. Gunsalus, Mike Boxem

Tartrate-resistant acid phosphatase (TRAP/ACP5) sex-specifically regulates bone maintenance in old mice, but the anabolic effects of mechanical loading is regulated in a sex-independent way

Bhavik Rathod, Jasmine Samvelyan, Nicole Gustafsson, Aneta Liszka, Narelle McGregor, Jianyao Wu, Claes Ohlsson, Anna Fahlgren, Natalie Sims, Jonas Fuxe, Göran Andersson, Jessica J Alm, Sara H Windahl

Human-mouse cross-species comparison identifies common and unique aspects of intestinal mesenchyme development

Kelli Johnson, Xiangning Dong, Zhiwei Xiao, Hamza Islam, Meghan Anderman, Ian Glass, Jason R. Spence, Katherine D. Walton

Functionally Essential and Structurally Diverse: Insights into the zebrafish Left-Right Organizer’s Cilia via Optogenetic IFT88 Perturbation and Volume Electron Microscopy

Favour Ononiwu, Melissa Mikolaj, Christopher Dell, Abdalla Wael Shamil, Kedar Narayan, Heidi Hehnly

Critical phenomenon underlies de novo luminogenesis during mammalian follicle development

Kim Whye Leong, Yuting Lou, Arikta Biswas, Jue Yu Kelly Tan, Boon Heng Ng, Xixun Lu, Xin Ping Joan Teo, Thong Beng Lu, Carlo Bevilacqua, Isabelle Bonne, Robert Prevedel, Tetsuya Hiraiwa, Chii Jou Chan

Distinct dermal fibroblasts direct mechano-chemical signaling to the epidermis during pregnancy

Yoshihiko Kobayashi, Kazunori Sunadome, Koichiro Maki, Hiroki Fukunaga, Hitomi Matsubara, Sahomi Ohkubo, Ritsuko Maki, Maki Yoshikawa, Aleksandra Tata, Purushothama Rao Tata, Ken-ichi Matsumoto, Taiji Adachi, Mitsuhiro Iwaki, Takuya Yamamoto, Fumiko Toyoshima

Patterned integrin–laminin adhesion coordinates epithelial collective cell migration

Anna Mertens, Nicola Moratscheck, Petra A Klemmt, Chaitanya Dingare, Marion Basoglu, Virginie Lecaudey

Single-cell morphodynamics predict cell fate decisions during mucociliary epithelial differentiation

Mari Tolonen, Ziwei Xu, Ozgur Beker, Varun Kapoor, Bianca Dumitrascu, Jakub Sedzinski

Under Pressure: A unique mechanoresponsive mechanism of body site-specific keratin regulation in palmoplantar epidermis

Sarah N. Steiner, Eric Horst, Mitre Athaiya, Craig N. Johnson, Joseph Y. Shen, Michelle L. Kerns, Geeta Mehta, Ramiro Iglesias-Bartolome, Pierre A. Coulombe

Sequoia affects Drosophila central nervous system development by regulating axonal extension and guidance

Noor Al-Hajri, Mar Alujas, Sofia J. Araújo, Guy Tear 

Sox2 Regulates Lateral Line Morphogenesis via Yap/Taz-Mediated Mechanotransduction

Akshai Janardhana Kurup, Aya Mikdache, Patricia Diabangouaya, Gwendoline Gros, Camila Garcia-Baudino, Cristian A. Undurraga, Andres F. Sarrazin, Pedro P. Hernandez

Cell Proliferation and Morphogenetic Compartmentalization in the Phoronid Phoronopsis harmeri: Conserved and Derived Patterns

Evgeny G. Ivashkin, Olga I. Taimanova, Anton I. Bogomolov, Elena N. Temereva

A structural transition ensures robust formation of skeletal muscle

Mario A. Mendieta-Serrano, Yiqi Hou, Sophie Theis, Thomas E. Hall, Shannon E. Taylor, Berta Verd, Robert G. Parton, Timothy E. Saunders

Dynamic expression and differential requirement of the myocyte fusogen Myomixer during distinct myogenic episodes in the zebrafish

Sunandan Dhar, Serena Thomas, Hui Li Yeo, Timothy E. Saunders, Sudipto Roy

Motile cilia spin the Reissner fiber, a tensioned and anchored extracellular thread essential for body morphogenesis

Elizabeth A. Bearce, Samuel G. Bertrand, Samara Williams, Sophie I. Fisher, Adamend L. Freda, Zoe H. Irons, Calvin Chmelir, Daniel T. Grimes

A self-limiting mechanotransduction feedback loop ensures robust organ formation

Yusuke Mori, Paul Robin, Anne Belle Briggs, Daniel S. Levic, Jiacheng Wang, Kira L. Heikes, Michel Bagnat, Edouard Hannezo, Akankshi Munjal

Dynamics of bicoid mRNA localisation and translation dictate morphogen gradient formation

T. Athilingam, E.L. Wilby, P. Bensidoun, A. Trullo, M. Verbrugghe, X. Shi, M. Lagha, T.E. Saunders, T.T. Weil

Roles of K-channel activity in feather bud morphogenesis

Madison Zitting, Zhou Yu, Ting-Xin Jiang, Ping Wu, Randall Widelitz, Cheng-Ming Chuong, Robert Hsiu-Ping Chow

| Genes & genomes

Aldehyde dehydrogenase protein: a placental glycogen trophoblast marker suitable to monitor placental pathologies in mouse models

Alka Rani, Melissa Arboleda, Heidi Stuhlmann

The Drosophila ovarian terminal filament imports molecules needed for lipid droplets, the fusome, and functional germ cells

Bhawana Maurya, Allan C Spradling

Integrated transcriptomic analysis reveals a metabolically quiescent state and gene expression networks related to intermediate and mature human 8-cell stage embryo resembling cells in vitro

Pauliina Paloviita, Sonja Nykänen, Sanna Vuoristo

Single-cell transcriptomic profiling of C. elegans Q neuroblast lineage during migration and differentiation

Felipe L. Teixeira, Brian Sanderson, Jennifer L. Hackett, Erik A. Lundquist

Active maintenance of meiosis-specific chromosome structures in C. elegans by the deubiquitinase DUO-1

Liesl G. Strand, Charlotte P. Choi, Savannah McCoy, Emmanuel T. Nsamba, Nicola Silva, Anne M. Villeneuve

AMP accumulation during mitochondrial stress induces transcription of cytosolic and mitochondrial protein synthesis components via NHR-180

Avijit Mallick, Theresa Ramalho, Yunguang Du, Rui Li, Levi Ali, Sookyung Kim, Pooja Rai, Andreas Bergmann, Lihua Julie Zhu, Cole M. Haynes

Neural crest induction requires SALL4-mediated BAF recruitment to lineage specific enhancers

Martina Demurtas, Samantha M. Barnada, Emma van Domselaar, Zoe H. Mitchell, Laura Deelen, Marco Trizzino

Editing-independent effects of Adar in Drosophila melanogaster

Khadija Hajji, Damiano Amoruso, Barbora Nováková, Nagraj Sambrani, Deying Yang, Anzer Khan, Vojtech Bystry, Alejandro Medaglia-Mata, Domenico Alessandro Silvestris, Ernesto Picardi, Mary A. O’Connell, Liam P. Keegan

Expression Atlas Of Dmrt Genes Across Sex And Development – Functional Insights From The Mouse Olfactory System

Rafael Casado-Navarro, Ana Bermejo-Santos, Rodrigo Torrillas-de la Cal, María Pilar Madrigal, Virgilia Olivé, Li Ying Chen-Chen, Sonia Amorós-Bru, Sandra Jurado, Esther Serrano-Saiz

Single-cell-scale spatial transcriptome of the developing and adult mouse ovary

Anthony S. Martinez, Tyler J. Gibson, Jennifer McKey

Decoding the Spatial and Epigenetic Logic of Early Skin Development

Nigel L. Hammond, Syed Murtuza Baker, Amanda McGovern, Antony Adamson, Andrew D Sharrocks, Magnus Rattray, Jill Dixon, Michael J. Dixon

Nicotinamide opposes ET-1’s adverse effect on uterine decidualization via EDNRB

Yuye Wang, Qing Ma, Meitong Chen, Yukako Kayashima, Jiayi Zhou, Balaji Rao, Jessica L Bowser, Xianwen Yi, Nobuyo Maeda-Smithies, Feng Li

Foxh1 is a locus-specific PRC2 recruiter governing germ layer silencing

Jin Cho, Clark L. Hendrickson, Nathan Mar, Ira L. Blitz, Margaret Fish, Wenqi Wang, Ken W.Y. Cho

Dissecting Gene Regulatory Networks Governing Human Cortical Cell Fate

Jingwen W. Ding, Chang N. Kim, Megan S. Ostrowski, Yashodara Abeykoon, Bryan J. Pavlovic, Jenelle L. Wallace, Tomasz J. Nowakowski, Alex A. Pollen

eIF4E assembly into C. elegans germ granules is essential for its repressive function

Carmen Herrera Sandoval, Christopher Borchers, Boyoon Yang, Becky Boyd, Heather A. Hundley, Scott T. Aoki

Resf1 is required for proper placental development and configuration of trophoblast cell-specific heterochromatin

Kei Fukuda, Kimiko Inoue, Chikako Shimura, Moe Kitazawa, Michiko Hirose, Shogo Matoba, Atsuo Ogura, Yoichi Shinkai

Ovarian development is driven by early spatiotemporal priming of the coelomic epithelium

Cyril Djari, Chloé Mayère, Maëva Guy, Aitana Perea-Gomez, Paul Barreau, Agathe Rozier, Anthony S. Martinez, Tyler J. Gibson, Cassandre Guérin, Herta Ademi, Dagmar Wilhelm, Jennifer McKey, Marie-Christine Chaboissier, Serge Nef

The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity

Sen-Lin Lai, Chris Q. Doe

Human NKX2.2 influences islet endocrine cell fate choices through regulation of WNT pathway genes

Christopher Schaaf, Fiona M. Docherty, Madison X. Rodriguez, Patrick Sean McGrath, Christopher J. Hill, Kristen L. Wells, Lori Sussel

A novel CHD4-CTCF regulatory axis drives key developmental programs and transitions in male germ cells

Rodrigo O. de Castro, Agustin Carbajal, Katarzyna P. Nowak, Ayelén González Montoro, Monika Kawecka, Luciana Previato, Roberto J. Pezza

SPT5 regulates Pol II pausing and elongation in different ways at early versus late embryonic stages

Alessandro Dulja, Marvin Mayer, Niklas Engel, Arkadiy K. Golov, Mattia Forneris, Yacine Kherdjemil, Songjie Feng, Rebecca R. Viales, Eileen E.M. Furlong

EHMT2 Controls Neural Crest-Derived Craniofacial Development but is Dispensable in Limb Development

Ye Liu, Yaguang Zhao, Minmin Liu, Paul Kim, Ji Liao, Di Lu, Huadie Liu, Piroska E. Szabó, Tao Yang

Transcriptomic and proteomic dynamics of ovarian follicle group culture resemble in vivo folliculogenesis

Andrea S. K. Jones, D. Ford Hannum, Taylor Schissel, Jordan H. Machlin, Vasantha Padmanabhan, Jun Z. Li, Ariella Shikanov

The genetic basis for DNA methylation variation across tissues and development

Jonathan Rosenski, Ofra Sabag, Eitan Marcus, Netanel Loyfer, Yuval Dor, Howard Cedar, Tommy Kaplan

Trimodal Single-Cell Gene Regulatory Networks Reveal Principles of Stemness Loss and Cell Fate Acquisition in Human Hematopoiesis

Carmen G. Palii, Steven Tur, Sirui Yan, William J.R. Longabaugh, Romeo Solano, F. Jeffrey Dilworth, Jeffrey A. Ranish, Marjorie Brand

An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted Perturb-seq

Judhajeet Ray, Evelyn Jagoda, Maya U. Sheth, James Galante, Dulguun Amgalan, Andreas R. Gschwind, Chad J. Munger, Jacob Huang, Glen Munson, Madeleine Murphy, Eugenio Mattei, Timothy Barry, Vasundhara Singh, Aarthee Baskaran, Helen Kang, Eugene Katsevich, Lars M. Steinmetz, Jesse M. Engreitz

Resetting of H3K4me2 during mammalian parental-to-zygote transition

Chong Wang, Yang Li, Yaqian Wang, Yong Shi, Xiangrui Meng, Wenbo Li, Jia Guo, Kaiyue Hu, Hao Chen, Jiawei Xu

Nucleosome stability safeguards cell identity, stress resilience and healthy aging

Hiroshi Tanaka, Brenna S. McCauley, Clara Guida, Xue Lei, Sha Li, Tatiana M. Moreno, K’leigh Guillotte, Zong-Ming Chua, Adrianna Abele, Aashna Lamba, Rouven Arnold, Adarsh Rajesh, Marcos G. Teneche, Laurence Haddadin, Anagha Deshpande, Aniruddha J. Deshpande, Alexandre Colas, Caroline Kumsta, Michael Petrascheck, Rolf Bodmer, Weiwei Dang, Peter D. Adams

Transcriptional Readthrough at Atf4 Locus Suppresses Rps19bp1 and Impairs Heart Development

Zengming Zhang, Tongbin Wu, Zeyu Chen, Danni Chen, Zhengyu Liang, Christopher Adams, Yu Gu, Mao Ye, Fhujjen Barroga, Sylvia Evans, Xiaohai Zhou, Ju Chen

| Stem cells, regeneration & disease modelling

Nonsense, but not frameshift, truncating mutations result in Cyclin D2 stabilisation in an induced pluripotent stem cell model of MPPH

Erica L. Harris, Rowan D. Taylor, Katarzyna Szymanska, Ailsa M.S. Rose, Jacquelyn Bond, Colin A. Johnson, James A. Poulter

Rejuvenation-Responsive and Senolytic-Sensitive Muscle Stem Cells Unveiled by CD200 and CD63 in Geriatric Muscle

Ye Lynne Kim, Young-Woo Jo, Takwon Yoo, Kyusang Yoo, Ji-Hoon Kim, Myungsun Park, In-Wook Song, Hyun Kim, Yea-Eun Kim, Sang-Hyeon Hann, Jong-Eun Park, Daehyun Baek, Young-Yun Kong

Short-term exposure to culture media used in human ART shapes early calcium oscillations in ICSI-fertilized mouse oocytes and impacts adult phenotype

Bernadette Banrezes, Thierry Sainte Beuve, Anne Frambourg, Alice Jouneau

Differentiation stage-specific use of cap-independent and cap-dependent translation initiation in hematopoiesis

Michael C. Mazzola, Ting Zhao, Anna Kiem, Trine A. Kristiansen, Karin Gustafsson, Lai Ping Wong, Emily Scott-Solomon, Marissa D. Fahlberg, Sarah Forward, Emane Rose Assita, Giulia Schiroli, Maris Handley, Youmna Kfoury, Tsuyoshi Fukushima, Samuel Keyes, Azeem Sharda, Jelena Milosevic, Hiroki Kato, Pavel Ivanov, David B. Sykes, Sheldon J. J. Kwok, Ruslan I Sadreyev, Vijay G. Sankaran, Ya-Chieh Hsu, David T. Scadden

Vcam1 in endothelial and stromal cells regulates hematopoietic stem cell contact with the niche

Octavia Santis Larrain, Alice Alhaj Kadour, Sobhika Agarwala, Wantong Li, Bradley W. Blaser, Michael R. Lasarev, Roxana Alexandridis, Anthony Veltri, Khaliun Enkhbayar, Elliott J. Hagedorn, Owen J. Tamplin

A kidney specific mouse model to study the effects of in vivo induction of Yamanaka factors

Katharina Lemberg, Gijs A.C. Franken, Korbinian M. Riedhammer, Selina Hölzel, Kirollos Yousef, Kraisoon Lomjansook, Gina Kalkar, Caroline M. Kolvenbach, Daniel Marchuk, Elena Zion, Ken Saida, Florian Buerger, Friedhelm Hildebrandt

Natural killer cell TGF-β signaling regulates senolytic activity and vascular patterning in the postnatal lung

Declan J. Gainer, Kassandra M. Coyle, Matthew T. Rätsep, Douglas Quilty, Brian Tran, Sofia Skebo, M. Martin VandenBroek, Kimberly L. Laverty, Yupu Deng, Shawyon P. Shirazi, Hugh JM Brady, Jennifer M.S. Sucre, Eric Vivier, Niraj Shrestha, Hing C. Wong, Duncan J Stewart, Nicolle J. Dominik, Mark L. Ormiston

JARID2 Inhibition Reprograms Human Hematopoietic Progenitor Cells To Enhance Bone Marrow Transplantation

Wentao Han, Hassan Bjeije, Hamza Celik, Michael Rettig, Nancy Issa, Andrew L. Young, Yanan Li, Infencia Xavier Raj, Christine R. Zhang, Aishwarya Krishnan, Tyler M. Parsons, Samantha C. Burkart, Jason Arand, Wei Yang, Jeffrey A. Magee, Grant A. Challen

Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties in vitro and in vivo

Michelle Lohbihler, Amos A. Lim, Stéphane Massé, Maggie Kwan, Omar Mourad, Olya Mastikhina, Brandon M. Murareanu, Malak Elbatarny, Renu Sarao, Beiping Qiang, Wahiba Dhahri, Matthew L. Chang, Alice L.Y. Xu, Amine Mazine, Shahryar Khattak, Sara S. Nunes, Kumaraswamy Nanthakumar, Michael A. Laflamme, Stephanie Protze

Glucocorticoid and Mineralocorticoid Receptors Jointly Promote Vascular Development in Kidney Organoids

Cory P. Johnson, Hannah M. Somers, Sophie E. Craig, Heath Fuqua, Lynne Beverly-Staggs, Kailee E. Tanaka, Sydney M. Brown, Charles H. Toulmin, Matthew D. Cox, Joel H. Graber, Melissa S. Maginnis, Hermann Haller

Resolving hematopoietic stem versus progenitor cell potential in the mouse dorsal aorta by differential Runx1 +110 enhancer activity

Giorgio Anselmi, Vincent Frontera, Christina Rode, Andrew Jarratt, Naeema T. Mehmood, Matthew Nicholls, Stella Antoniou, Emanuele Azzoni, John Stamatoyannopoulos, Ditsa Levanon, Yoram Groner, Marella F.T.R. de Bruijn

Hypoxia/HIF Signaling Negatively Regulates Bone Marrow Adiposity after Radiation Exposure

Cheyenne A. Jones, Wendi Guo, Kiana A. Gunn, Cahil Potnis, Amaya Sheffield, Colleen Wu

Exploring mechanisms of scar-free skin wound healing in adult zebrafish in comparison to mouse

İsmail Küçükaylak, Francisco Javier Martínez Morcillo, Kai Halwas, Nils Reiche, Manuel Metzger, Petra Comelli, Jürgen Brinckmann, Sabine Eming, Matthias Hammerschmidt

Hic2 fast-tracks iPS cell generation by suppressing KLF4-dependent epidermal detour

Meryam Beniazza, Masahito Yoshihara, Daniel F Kaemena, James Ashmore, Suling Zhao, Michael O’Dwyer, Emil Andersson, Victor Olariu, Shintaro Katayama, Abdenour Soufi, Kosuke Yusa, Keisuke Kaji

Smed-pou4-2 regulates mechanosensory neuron regeneration and function in planarians

Ryan A. McCubbin, Mohammad A. Auwal, Shengzhou Wang, Sarai Alvarez Zepeda, Roman Sasik, Robert W. Zeller, Kelly G. Ross, Ricardo M. Zayas

Chondrolectin regulates the sublaminar localization and regenerative function of muscle satellite cells in mice

Lijie Gu, Kun Ho Kim, Xiyue Chen, Stephanie N Oprescu, Yufen Li, Junxiao Ren, Shihuan Kuang, Feng Yue

Signals from the head and germinative region differentially regulate regeneration competence of the tapeworm Hymenolepis diminuta

Elise McCollough Nanista, Landon Elizabeth Poythress, Isabell Reese Skipper, Trevor Haskins, Marieher Felix Cora, Tania Rozario

Microbes and diet reshape the intestine via distinct cellular dynamics

Alessandro Bonfini, Nicolas Buchon

Hyper-proliferation of Adipose Progenitors During Developmental Adipogenesis Programs Higher Adipocyte Number and Early-onset Obesity in Offspring Born to Obese Dams

TB Scheidl, JS Yoon, JL Wager, S Yonan, A Lakhdar, S Kailasam, JA Thompson

A double-assurance mechanism restrains generation of high potential transit-amplifying progenitors during neurogenesis

Cyrina M. Ostgaard, Arjun Rajan, Sophia R. Davidson, Cheng-Yu Lee

Tumors mimic the niche to inhibit neighboring stem cell differentiation

Yang Zhang, Yuejia Wang, Jinqiao Song, Lizhong Yan, Ziguang Wang, Dongze Song, Yudi Zhao, Shaowei Zhao

The circadian regulator PER1 inhibits osteoclastogenesis by activating inflammatory genes

Nobuko Katoku-Kikyo, Elizabeth K. Vu, Samuel Mitchell, Ismael Y. Karkache, Elizabeth W. Bradley, Nobuaki Kikyo

Myc and Tor drive growth and cell competition in the regeneration blastema of Drosophila wing imaginal discs

Felicity Ting-Yu Hsu, Rachel Smith-Bolton

Piezo1–Yap1 signalling translates tissue mechanics into regenerative cell states

Fernando Ferreira, Jaime A. Espina, Artemis G. Korovesi, Inês A. Ferreira, Quentin Tirel, Elias H. Barriga

WDR5 and Myc Cooperate to Regulate Formation of Neural Crest Stem Cells

Karlin Compton, Elizabeth Barter, Carole LaBonne

A STAT3-regulated lncRNA integrates microRNA biogenesis and sequestration to safeguard naïve pluripotency

Vincent Giudice, Florence Perold, Yannicke Pijoff, Nathalie Doerflinger, Nicolas Allègre, Claire Chazaud, Irène Aksoy, Pierre Savatier, Pierre-Yves Bourillot

The livebearers platyfish and swordtails partially regenerate their hearts with persistent scarring

Vincent Hisler, Lana Rees, Simon Blanchoud, Heidi E.L. Lischer, Rémy Bruggmann, Anna Jaźwińska

Regional Signaling Controls Stem Cell-Mediated Regeneration in an Invertebrate Chordate

Tal Gordon, Tom Levy, Chester Jiamu Yu, Benyamin Rosental, Lauren Lubeck, Lucia Manni, Irving L. Weissman, Ayelet Voskoboynik

Maternal–fetal inflammation affects Cdh1/E-cadherin epigenetic regulation and craniofacial development

Diogo Nani, Lucas Alvizi, Heloisa Maria de Siqueira Bueno, Ellen Cristina Miranda Lacerda, Maria Rita Passos-Bueno

Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids

Jingliang Simon Zhang, Brian Guy, Clayton P. Santiago, Caterina Tiozzo, Meghana Sreenath, Ya-Wen Chen, Seth Blackshaw, Robert J. Johnston Jr.

Accelerated Tempo of Cortical Neurogenesis in Down Syndrome

Jingwen W Ding, Chang N Kim, Marilyn R Steyert, Andrew T Yuan, David Shin, Dimitar Ivanov, Tomasz J Nowakowski, Alex A Pollen

Reprogramming Factors Activate a Non-Canonical Oxidative Resilience Pathway That Can Rejuvenate RPEs and Restore Vision

Yuancheng Ryan Lu, James C. Cameron, Yan Hu, Han Shen, Shintaro Shirahama, Alexander Tyshkovskiy, Zhaoyi Chen, Jiahe Ai, Daniel Y. Zhu, Margarete M. Karg, Lindsey A. Chew, George W. Bell, Siddhartha G. Jena, Yue He, Philip Seifert, Daisy Y. Shu, Mohamed A. EI-Brolosy, Qiannuo Lou, Bohan Zhang, Anna M. Puszynska, Xiaojie Qiu, Xiao Tian, Meredith Gregory-Ksander, Vadim N. Gladyshev, David A. Sinclair, Magali Saint-Geniez, Jason D. Buenrostro, Catherine Bowes Rickman, Bruce R. Ksander, Jonathan S. Weissman

Germline stem cell isolation, lineage tracing, and aging in a protochordate

Tom Levy, Chiara Anselmi, Katherine J. Ishizuka, Tal Gordon, Yotam Voskoboynik, Erin McGeever, Angela M. Detweiler, Liron Levin, Karla J. Palmeri, Daniel Dan Liu, Rahul Sinha, Benjamin F. Ohene-Gambill, Tal Raveh, Maurizio Morri, Virginia Vanni, Lucia Manni, Debashis Sahoo, Norma F. Neff, Benyamin Rosental, Irving L. Weissman, Ayelet Voskoboynik

RNA helicase Ddx21 safeguards fetal HSPC expansion by recruiting Kdm5a to epigenetically sustain ribosomal and hematopoietic gene transcription

Adrian On-Wah Leung, Chang Li, Xianyin Huang, Zhuming Fan, Yuning Chen, Jiaxing Liu, Hong-Man Lin, Xiaoming Cui, Fujia Zhang, Ruoxi Niu, Kam-Tong Leung, Hoi-Hung Cheung

Inhibition of the neurodevelopmental disorder-associated 16p11.2 gene QPRT leads to altered cell type distribution in human stem cell-derived cerebral organoids

Julia Schwarzpaul, Clara M. Droell, Afsheen Kumar, Harishny Sarma, Madeleine Gruenauer, Selen Z. Ucar, Julio C. Hechavarría, Andreas G. Chiocchetti, Denise Haslinger

Sonoepigenetic Modification Mechanoprimes Early Osteogenic Commitment in Mesenchymal Stem Cells

Lizebona A. Ambattu, Blanca del Rosal, Carmelo Ferrai, Leslie Y. Yeo

Setdb1 safeguards proper differentiation of adult intestinal stem cells by controlling chromatin accessibility and transcriptome variability

Ioanna Peraki, Ioannis K. Deligiannis, Dimitris Botskaris, Marianna Stagaki, Haroula Kontaki, Elena Deligianni, Giannis Giannoulakis, Matthieu D. Lavigne, Celia P. Martinez-Jimenez, Iannis Talianidis

| Plant development

Molecular characterization of capulet2 reveals the importance of ANAPHASE PROMOTING COMPLEX 6 maternal expression in endosperm development

Yuri S. van Ekelenburg, Ida V. Myking, Cathal Meehan, Morten P. Hauger, Shinichiro Komaki, Keiko Sugimoto, José Gutierrez-Marcos, Paul E. Grini

De novo meristem development in Marchantia requires light and an apical auxin minimum

Eva-Sophie Wallner, Natalie Edelbacher, Liam Dolan 

Supergene control of chiral development in mirror-image flowers
Haoran Xue, Marco Saltini, Nicola Illing, Kelly Shepherd, Olivia Page-Macdonald, Oliver Marketos, Caroline Robertson, Anand Shankar, Sarah Süß, Christian Kappel, Saleh Alseekh, Eva E. Deinum, Robert A. Ingle, Michael Lenhard

The role of FRUITFULL controlling cell cycle during early flower development revealed by time series snRNA-seq experiments

Peilin Chen, Xiaocai Xu, Cezary Smaczniak, Bénédicte Desvoyes, Crisanto Gutiérrez, Robert Sablowski, Kerstin Kaufmann, Jose M Muino

Transgenerational polarity axis inheritance during Ceratopteris embryogenesis

Sjoerd Woudenberg, Andrew R.G. Plackett, Zhaodong Hao, Hidemasa Suzuki, Luis Alonso Baez, Cecilia Borassi, Thorsten Hamann, Minako Ueda, Jane A. Langdale, Joris Sprakel, Jasper van der Gucht, Dolf Weijers

COCHLEATA controls spatial regulation of cytokinin and auxin during nodule development

Karen Velandia, Muhammad Nouman Sohail, Tiana Scott, Alejandro Correa-Lozano, Alannah Mannix, Eloise Foo

Transfer RNA modifications during rhizome development in Oryza longistaminata

Wenze Li, Guangzhao Yang, Haoyue Xue, Ruichen Ma, Chaoying Zhang, Ruixuan Yao, Yajun Li, Xukai Li, Fengyi Hu, Peng Chen, Zheng Li

A common pathway controls cell size in the sepal and leaf epidermis leading to a non-random pattern of giant cells

Frances K. Clark, Gauthier Weissbart, Xihang Wang, Kate Harline, Chun-Biu Li, Pau Formosa-Jordan, Adrienne H. K. Roeder

A symbiotic MLO gene regulates root development via RALF34-triggered Ca2+ signalling in Lotus japonicus

Filippo Binci, Giacomo Guarneri, Sofía Cristina Somoza, Filippo Vascon, Arianna Capparotto, Edoardo Di Nuzzo, Giacomo Rago, Laura Cendron, Lorella Navazio, Marco Giovannetti

Progressive oxygenation of developing leaves directs morphogenesis

Gabriele Panicucci, Vinay Shukla, Viktoriia Voloboeva, Leonardo Jo, Kees van Kollenburg, Sara Buti, Laura Dalle Carbonare, Francesco Licausi, Daan A. Weits

Transcriptional cofactor AtSDR4L and its paralog DIG2 repress somatic embryogenesis during post-embryonicdevelopment in Arabidopsis

Dongeun Go, Bailan Lu, Liang Song

A Key Role for S-Nitrosylation in Immune Regulation and Development in the Liverwort Marchantia polymorpha

Nadra Tabassum, Justin Goodrich, Gary J. Loake

| Environment, evolution and development

Expanding the fly eye gene regulatory network: from Drosophila to the hoverfly Episyrphus balteatus

T. Navarro, J. Torres, R. Sáez-Moreno, G. Guerrero, I. Almudí, A. Iannini, J. Figueras, K Wotton, S. Aerts, F. Casares

Oogenesis and germinal bed morphology of the brown anole (A. sagrei)

Bonnie K. Kircher, Antonia Weberling, Erin J. Vance, Natalia A. Shylo, Katherine Starr, Zoe B. Griffin, Hannah Wilson, Melainia McClain, Florian Hollfelder, Suzannah A. Williams, Thomas J. Sanger, Richard R. Behringer, Paul A. Trainor

doi:

Getting a head start: Craniofacial heterochrony in marsupials involves dynamic changes to molecular and cellular mechanisms underlying neural crest development

Axel H Newton, Ella R Farley, Andrew T Major, Jennifer C Hutchison, Ben M Lawrence, Karen E Sears, Marilyn B Renfree, Aiden M C Couzens, Geoff Shaw, Sara Ord, Richard A Schneider, Andrew J Pask

The heterochronic activation of TGF-β signaling drives the diversity of the avian sterna

Seung June Kwon, Zhaonan Zou, Mizuki Honda, Shiro Egawa, Shinya Oki, Yuji Atsuta

WntA expression and wing transcriptomics illuminate the evolution of stripe patterns in skipper butterflies

Jasmine D. Alqassar, Teomie S. Rivera-Miranda, Joseph J. Hanly, Christopher R. Day, Silvia M. Planas Soto-Navarro, Paul B. Frandsen, Riccardo Papa, Arnaud Martin

Integrated Genomic and Methylome Profiling Reveals Promoter Repression and Age-Linked CpGs in the California Mussel

Laurel S. Hiebert, Ava Soesbe, Tzung-Fu Hsieh, Qirui Cui, Soojin V. Yi

The evolution of investment in innate-like and diversified T cell receptors across development

Reese A. Martin, Anna E. Savage, Ann T. Tate

Rewiring of chromatin regulation underlies the evolution of brown algal multicellularity

Jeromine Vigneau, Jaruwatana Sodai Lotharukpong, Pengfei Liu, Remy Luthringer, Bérangère Lombard, Damarys Loew, Fabian B. Haas, Michael Borg, Susana M Coelho

Developmental temperature drives distinct transcriptomic responses to acute temperatures and correlated differences in thermal tolerance

Alison Hall, Manali Rege-Colt, Melissa Pespeni

PIF4-mediated regulation of H2O2 homeostasis controls Arabidopsis seedling thermomorphogenesis

Ritesh Kumar Raipuria, Kumud Saini, Mahesh Kumar Panda, Aditi Dwivedi, Aashish Ranjan

Cell Biology

Separately prestored proteasome components to prevent polyspermy

Liying Wang, Chao Liu, Xing Wang, Yueshuai Guo, Qiuxing Zhou, Yinghong Chen, Huafang Wei, Xiaoming Huang, Shuai Liu, Wei Li, Chun So, Ling Sun, Renjie Jiao, Xuejiang Guo, Qiang Guo, Wei Li

Mitochondrial organization in the developing proximal tubule is controlled by LRRK2

Mohsina Anjum Khan, Kyle Bond, Elyse Grilli, Daniel Cameron, Liyang Zhao, Sunder Sims-Lucas, Andrew P. McMahon, Thomas J. Carroll, Leif Oxburgh

Mitochondrial fission regulates ROS for ventral furrow formation in Drosophila gastrulation

Somya Madan, Sayali Chowdhary, Sakshi Phalke, Harsh Mittal, Manos Mavrakis, Richa Rikhy

DISC1-PML protein interaction for congenital CMV infection-induced cortical neural progenitor deficit: perturbance of host signaling via viral IE1

Atsushi Saito, Stephanie Tankou, Kazuhiro Ishii, Makiko Sakao-Suzuki, Edwin C. Oh, Hannah Murdoch, Ho Namkung, Sunday Adelakun, Keiko Furukori, Masahiro Fujimuro, Paolo Salomoni, Gerd G. Maul, Gary S. Hayward, Qiyi Tang, Robert H. Yolken, Miles D. Houslay, Nicholas Katsanis, Isao Kosugi, Kun Yang, Atsushi Kamiya, Koko Ishizuka, Akira Sawa

Oocyte surface proteins EGG-1 and EGG-2 are required for eggshell integrity in Caenorhabditis elegans

Ji Kent Kwah, Shannon Pfeiffer, Mst Gitika Khanom, Aimee Jaramillo-Lambert

Mitochondria-Lysosome Crosstalk Shapes Metabolic Transition in Neonatal Enterocytes

Gonzalo Herranz, Diego Alonso-Larre, Tamara González, Laura Akintche, Alejandra Ramos-Manzano, Marta Iborra-Pernichi, María Velasco de la Esperanza, Covadonga Díaz-Díaz, Ian G Ganley, Patricia Boya, Sara Cogliati, Nuria Martínez-Martín, Fernando Martín-Belmonte

ANKRD5: a key component of the axoneme required for sperm motility and male fertility

Shuntai Yu, Guoliang Yin, Peng Jin, Weilin Zhang, Yingchao Tian, Xiaotong Xu, Tianyu Shao, Yushan Li, Fei Sun, Yun Zhu, Fengchao Wang

Mouse germline cysts contain a fusome that mediates oocyte development

Madhulika Pathak, Allan C. Spradling

Organ-specific rewiring of mitochondrial integrity through COX7A dictates cellular ploidy control

Archan Chakraborty, Sophia DeLuca, Meera Gangasani, Stephen Rogers, Nenad Bursac, Donald T. Fox

Essential role for Nup43 in Drosophila fertility and spermiogenesis through Mysin VI-dependent actin cone assembly dynamics

Jyotsna Kawadkar, Ashley Suraj Hermon, Rohit Kumar, Ram Kumar Mishra

ROCK2 inhibition has a dual role in reducing ECM remodelling and cell growth, while impairing migration and invasion

Daniel A. Reed, Anna E. Howell, Nadia Kuepper, Alice M. H. Tran, Astrid Magenau, Deborah S. Barkauskas, Max Nobis, Cecilia R. Chambers, Victoria Lee, Lily M. Channon, Jessie Zhu, Shona Ritchie, Janett Stoehr, Kaitlin Wylie, Julia Chen, Denise Attwater, Kate Harvey, Sunny Z. Wu, Kate Saw, Ruth J. Lyons, Anaiis Zaratzian, Michael Tayao, Andrew Da Silva, David Gallego-Ortega, Anthony J. Gill, Thomas R. Cox, Brooke A. Pereira, Kendelle J. Murphy, Jennifer P. Morton, Elgene Lim, Alexander Swarbrick, Sandra O’Toole, Michael S. Samuel, C. Elizabeth Caldon, Alexandra Zanin-Zhorov, Paul Timpson, David Herrmann

Histone methyltransferase DOT1L differentially affects the development of dendritic cell subsets

Rianne G. Bouma, Willem-Jan de Leeuw, Aru Z. Wang, Muddassir Malik, Joeke G.C. Stolwijk, Veronique A.L. Konijn, Anne Mensink, Natalie Proost, Maarten K. Nijen Twilhaar, Tibor van Welsem, Negisa Seyed Toutounchi, Alsya J. Affandi, Jip T. van Dinter, Fred van Leeuwen, Joke M.M. den Haan

Mechanical context defines integrin requirement for maintaining epithelia architecture

Lourdes Rincón-Ortega, Cecilia H. Fernández-Espartero, Isabel M. Palacios, Acaimo González-Reyes, María D. Martín-Bermudo

The I-BAR domain protein baiap2l1a is required for protrusion and lateral elongation of epithelial microridge structures

Yasuko Inaba, Kimika Iwasaki, Aoi Nakamura, Shiro Suetsugu, Yasumasa Bessho

Integrins pattern the Drosophila embryonic neuroepithelium by influencing progenitor morphodynamics, division and position

Lamiya Dohadwala, Anupriya Garg, Maithreyi Narasimha

Role of Klhl14 in senescence and epithelial-to-mesenchymal transition via TGF-β modulation

Rufina Maturi, Abel Soto-Gamez, Anne L Jellema-de Bruin, Matteo Esposito, Schelto Kruijff, Gabriella De Vita, Rob P. Coppes

Uncovering the role of laminin(lama5) in maintenance of epithelial identity and polarity in bilayer zebrafish epidermis during development

Tooba Khan

Gap junction communication regulates luminal-myoepithelial crosstalk and cell differentiation in a bilayered human mammary epithelial cell model

Alec McDermott, Melany Juarez, David Tovar-Parra, Capucine Duval, Shunmoogum (Kessen) Patten, Isabelle Plante

Spatio-temporal control of nuclear mechanotransduction during Epithelial-to-Mesenchymal Transition

Ronan Bouzignac, Amandine Palandri, Amal Zine El Aabidine, Thomas Mangeat, Tatiana Merle, Martine Cazales, Antonio Trullo, Christian Rouviere, Virginia Pimmett, Mounia Lagha, Magali Suzanne

Rotational migration in human pancreatic ductal organoids depends on actin and myosin activity

Gengqiang Xie, Chaity Modak, Olalekan H Usman, Raphael WF Tan, Nicole Coca, Gabriela De Jesus, Yue Julia Wang, D. Thirumalai, Xin Li, Jerome Irianto

A dynamic repertoire of wound closure strategies precedes whole-body regeneration

Allison P. Kann, Mansi Srivastava

Camsap3-Mediated Microtubules Maintain Transzonal Projections Essential for Germline-Soma Communication during Ovarian Follicle Maturation in Mice

Akihiro Aikawa, Junya Ito, Mika Toya, Masamitsu Sato

Modelling

Bayesian phylodynamics for developmental biology: incorporating age-dependence

Nicola Mulberry, Julia Pilarski, Jana Dinger, Tanja Stadler

Epigenetic–metabolic axis in the temporal scaling of mammalian cortical neurogenesis across species

Quan Wu, Charlotte Manser, Taeko Suetsugu, Ryo Yoshida, Hideya Sakaguchi, Yoichi Nabeshima, Hiroshi Kiyonari, Ruben Perez-Carrasco, Fumio Matsuzaki

Simulation-Based Inference of Cell Migration Dynamics in Complex Spatial Environments

Jonas Arruda, Emad Alamoudi, Robert Mueller, Marc Vaisband, Ronja Molkenbur, Jack Merrin, Eva Kiermaier, Jan Hasenauer

Tools & Resources

A Novel 3D Visualization Method in Mice Identifies the Periportal Lamellar Complex (PLC) as a Key Regulator of Hepatic Ductal and Neuronal Branching Morphogenesis

Tongtong Xu, Fujun Cao, Ruihan Zhou, Qin Chen, Jian Zhong, Yulin Wang, Chaoxin Xiao, Banglei Yin, Chong Chen, Chengjian Zhao

FishFeats: streamlined quantification of multimodal labeling at the single-cell level in 3D tissues

Gaëlle Letort, Tanya Foley, Ilona Mignerey, Laure Bally-Cuif, Nicolas Dray

CUT&TIME captures the history of open chromatin in developing neurons

Kiara C. Eldred, Matthew Wooten, Derek H. Janssens, Joshua Hahn, Shane J Neph, Sierra J. Edgerton, Gracious Wyatt-Draher, Stephanie M. Sherman, Jane E. Ranchalis, Andrew B. Stergachis, Thomas A. Reh, Steven Henikoff

SpinePy enables automated 3D spatiotemporal quantification of multicellular in vitro systems

Ryan G. Savill, Alba Villaronga-Luque, Marc Trani Bustos, Yonit Maroudas-Sacks, Julia Batki, Alexander Meissner, Allyson Q. Ryan, Carl D. Modes, Otger Campàs, Jesse V Veenvliet

Poly(A) probe HCR RNA-FISH specifically marks pyriform nurse cells in the brown anole lizard ovary

Zoe B. Griffin, Bonnie K. Kircher, Richard R. Behringer

Prediction of zoonotic virus-host transmissibility using comparative airway organoids

Namwook Kim, Christine S. Kim, Junhee Park, Hyeon Jun Yoon, Ju Ang Kim, Yong Gun Kim, Joonhyung Kim, Injun Song, Donghyuck Ahn, Jihyeon Myeong, Byungmoo Oh, Jaeyoon You, Eunju Hong, Sukin Jeong, Kyungmoo Yea, Sung Won Kim, Ok Sarah Shin, Seung Joon Kim, Minho Lee, Myungin Baek, Youngtae Jeong

Automated Image-Based Profiling of Pluripotent Stem Cell Colonies

Rui Geng, Benjamin L. Kidder

RNAi Gene knockdown of R-opsin and F-actin in the marine annelid Streblospio benedicti by delivering dsRNA

Jose Maria Aguilar-Camacho, Christina Zakas

Stable Maintenance of Two-Cell-Like Cells from Embryonic Stem Cells Reveals Chromatin and Super Enhancer Regulation of MERVL Elements

Rui Geng, Benjamin L. Kidder

Human DCM-time machine unravels cell state changes during primitive gut tube differentiation

Marieke E. van Leeuwen, Beatrice F. Tan, Evelyne Wassenaar, Esther Sleddens-Linkels, Ruben Boers, Cristina Gontan, Joost Gribnau

Identification of optimal fluorophores for use in the Drosophila embryo

Bernardo Chapa-y-Lazo, Thamarailingam Athilingam, Prabhat Tiwari, Prachi Pathak, Shaobo Zhang, Sophie Theis, Timothy E Saunders

Direct, high-throughput linking of single cell imaging and gene expression

Catherine K Xu, Georg Meisl, Nikita Moshkov, Karolis Goda, Alexey Shkarin, Maximilian F Schlögel, Tuomas PJ Knowles, Linas Mazutis, Jochen Guck

Streamlined Montage Cryo-Electron Tomography for Exploring the Ultrastructure of Cells and Tissues

Ryan Hylton, Micaela Boiero Sanders, Adriana Prajica, Gavin Rice, Stefan Raunser

Recapitulating apicobasal tissue polarity in extracellular matrix incorporated airway organoids

Zhuowei Gong, Dhruv Bhattaram, Laura Porritt, Kian Golestan, Amir Barati Farimani, Amy L. Ryan, Daniel J. Weiss, Xi Ren

Bridging the resolution gap in cryo-CLEM by introducing cryo-SXT: cryo-CLXEM

Johannes Groen, Anastasia Gazi, Sergey Kapishnikov, Anne Brelot, Matthijn Vos, Jost Enninga, Eva Pereiro, Anna Sartori-Rupp

Optimized CRISPR/Cas9 Electroporation and Single Cell Cloning Protocol for Generating Pure Cellular Models in Human Immortalized Myoblasts

Adrien Rihoux, Alexie Gagné, Jean Mezreani, Clémence Gonthier-Cummings, Laura K. Hamilton, Eric Samarut, Martine Tétreault

Deep3DSIM: Super-resolution imaging of thick tissue using 3D structured illumination with adaptive optics

Jingyu Wang, Danail Stoychev, Mick Phillips, David Miguel Susano Pinto, Richard M. Parton, Nick Hall, Josh Titlow, Ana Rita Faria, Matthew Wincott, Dalia Gala, Andreas Gerondopoulos, Niloufer Irani, Ian Dobbie, Lothar Schermelleh, Martin Booth, Ilan Davis

SPACE: spatially resolved multiomic analysis for high-throughput CRISPR screening in 3D models

Mengwei Hu, Yi Cui, Qianhui Huang, Khoi Chu, Sierra McKinzie, Michael Patrick, Sharanya Iyengar, Maerjianghan Abuduli, Marianne Spatz, Nandita Joshi, Brendan Miller, Shams Vellarikkal, Timothy Riordan, Danny Bitton, Jan Lubojacky, Iya Khalil, Federica Piccioni, Michael Rhodes, Alex Tamburino, Shanshan He, Joseph Beechem, Vanessa Peterson

ArchVelo: Archetypal Velocity Modeling for Single-cell Multi-omic Trajectories

Maria Avdeeva, Sarah Walker, Joris van der Veeken, Alexander Rudensky, Yuri Pritykin

Generation of Valvular Interstitial Cells from Human Pluripotent Stem Cells

Amine Mazine, Alexander A. Mikryukov, Ian Fernandes, Clifford Z. Liu, Soheil Jahangiri, Marcy Martin, Eric K. N. Gähwiler, Melanie Generali, Juliana Gomez, Neda Latifi, Yifei Miao, Yu Liu, Michael A Laflamme, Craig A Simmons, Simon P. Hoerstrup, Maximilian Y. Emmert, Bruce D. Gelb, Mingxia Gu, Gordon M. Keller

Automatic Body Morphometric Analysis of Adult Zebrafish Using MicroCT

Mohammed Kanani, Ronald Young Kwon

Alternating Angle Milling Suppresses Streaking Artifacts in FIB-SEM Imaging

Gleb Shtengel, Wei Qiu, Jesse Aaron, Arthur S. Crowe, Alexey A. Polilov, Katerina Karkali, Christopher K.E. Bleck, Harald H. Hess

Smart Microscopy: Current Implementations and a Roadmap for Interoperability

Lucien Hinderling, Hannah S. Heil, Alfredo Rates, Philipp Seidel, Manuel Gunkel, Benedict Diederich, Thomas Guilbert, Rémy Torro, Otmane Bouchareb, Claire Demeautis, Célia Martin, Scott Brooks, Evangelos Sisamakis, Erwan Grandgirard, Jerome Mutterer, Harrison Oatman, Jared Toettcher, Andrii Rogov, Nelda Antonovaite, Karl Johansson, Johannes K. Ahnlinde, Oscar André, Philip Nordenfelt, Pontus Nordenfelt, Claudia Pfander, Jürgen Reymann, Talley Lambert, Marco R. Cosenza, Jan O. Korbel, Rainer Pepperkok, Lukas C. Kapitein, Olivier Pertz, Nils Norlin, Aliaksandr Halavatyi, Rafael Camacho

Botanic Spectrum Analyser: A Deep Learning GUI for Plant Image Segmentation in Hyperspectral and RGB Phenotyping

Jason John Walsh, Levent Görgü, Emilie Jacob, Victoria Poulain, Laurent Gutierrez, Eleni Mangina, Sónia Negrão

Research practice & education

Mirror-image inversion in commonly used compound microscopes

François Lapraz, Céline Boutres, Baptiste Monterroso, Stéphane Noselli

Temperature-dependence of Early Development of Zebrafish and the Consequences for Laboratory Use and Animal Welfare

Angelina Miller, Katja L. Schröder, Karsten E. Braun, Caitlin Steindorf, Richard Ottermanns, Martina Roß-Nickoll, Henner Hollert, Thomas Backhaus

Speaker responses to audience-induced social-evaluative threat: Evidence from scientific presentation tasks in immersive virtual reality

Sue Lim, Ralf Schmälzle, Gary Bente

Reducing the environmental footprint of laboratory research using visual communications: A pilot study in Spain

Raquel Marco-Ferreres, Silvia Ayora, Carmela Cela, Álvaro Sahún-Español, María López-Sanz, Pablo Izquierdo

Natural history museums are missing an opportunity to present research and collections on YouTube

Selina A. Ruzi, Adrian A. Smith, Nicole M. Lee, Nicolás J. Galvez, Timothy A. Dinh

Evaluation of the Utility of a Research Ethics Training Course to Graduate Students

Michael D. Schaller, Peter H. Mathers

10 recommendations for strengthening citizen science for improved societal and ecological outcomes: A co-produced analysis of challenges and opportunities in the 21st century

Jack Nunn, Håkon da Silva Hyldmo, Lauren McKnight, Heather McCulloch, Jennifer Lavers, Julie Old, Laura Smith, Nicola Grobler, Cheryl Tan Kay Yin, Wing Yan Chan, Candice Raeburn, Nittya S. M. Simard, Adam Kingsley Smith, Sam Van Holsbeeck, Eleanor Drinkwater, Kit Prendergast, Emma Burrows, Christopher L. Lawson

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