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Displaying posts with the tag: niche [Clear Filter]

Secret talk between epithelium and endothelium determines hair follicle stem cell fate

Posted by on November 6th, 2019

By Kefei Nina Li and Prachi Jain   Stem cells are typically defined by their ability to self-renew and differentiate. These activities are tightly controlled by both intrinsic cues and extrinsic cues from the microenvironment, known as the SC niche. This niche consists of multiple components, among which blood vessels (BVs) are critical as they[…]

Stem cell makes its own niche: the story behind the paper

Posted by on July 7th, 2018

In our recent paper published in Nature, we unravel a new mechanism of an extracellular matrix protein secreted by muscle satellite (stem) cells, thereby playing the unusual role of acting as a signaling molecule to maintain the stem cell population. Here, I share the story behind this discovery and discuss the questions related to niche[…]

Multiple stem cells, population asymmetry and position-dependent heterogeneity emerge as common features of a niche for Drosophila Follicle Stem Cells and mammalian Intestinal Stem Cells

Posted by on June 16th, 2017

A discussion of “Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling,” Nat Cell Biol, 2017. 19(5): p. 433-444.   We have recently revised the model of Follicle Stem Cell (FSC) organization in the Drosophila ovary, showing that there is a much larger population of stem cells than formerly realized, that[…]

Stem cells at home

Posted by on April 12th, 2012

We depend on our own comfort zones to keep us grounded, and stem cells are no different.  A recent paper in Development describes how the adhesion that keeps a stem cell in its niche is regulated. A stem cell’s niche is important in maintaining its long-term undifferentiated state.  A great model of stem cell niche[…]

Post-doctoral position in Drosophila hematopoiesis: deciphering the niche function

Posted by on March 20th, 2012

A 3 years post-doctoral position is immediately available in the laboratory of Michèle Crozatier and Alain Vincent, at the Centre de Biologie du Développement CNRS/Toulouse University, France. One main topic of the lab concerns Drosophila hematopoiesis, the hematopoietic niche and the plasticity of cell fates in the lymph gland (http://www-cbd.ups-tlse.fr/spip.php?rubrique53). The candidate will further explore[…]

Establishing a niche

Posted by on April 12th, 2011

If there is hope to fully understand stem cells, then the environment surrounding those stem cells must be understood too.  A recent Development paper describes important results on niche establishment in Drosophila. Stem cell niches play an important role in regulating stem cell self-renewal and differentiation.  The Drosophila testis has two populations of stem cells[…]