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Introducing ACME: the species-versatile fixation and dissociation solution for single cell analysis

Posted by on July 1st, 2020

This post highlights the approach and findings of a new research article available in preprint on BioRxiv. This feature was written by members of the Solana lab, authors of that paper. Single cell techniques are revolutionising biology, but at the moment they are largely limited to traditional model organisms and require access to specialised equipment[…]

Turning lemons into lemonade…sick planarians reveal link between microbiome and regeneration

Posted by on September 30th, 2016

Commentary on Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38 in eLife 2016; 5: e16793 DOI:   During our research as biologists we endure numerous problems, failures, and setbacks in our efforts to advance scientific knowledge. But sometimes the very problems we encounter are opportunities in disguise. This was[…]

Forgotten classics- T. H. Morgan and planarian regeneration

Posted by on February 16th, 2016

  Morgan, T.H. (1898) Experimental studies of the regeneration of Planaria maculata. Archiv für Entwicklungsmechanik der Organismen 7, 364-397 Recommended by Alejandro Sánchez Alvarado (Stowers Institute)   Some classic papers are only cited a few times, and the work therein has been largely forgotten. But that does not mean these works are not worth revisiting.[…]

A day in the life of a Planarian lab

Posted by on April 12th, 2015

Greetings and warm welcome to the “Planarian lab @ Oxford” The lab is based in the Department of Zoology in The Tinbergen Building on South parks Road in the “Land of dreaming spires; Oxford”. Zoology Department in Oxford, has a rich heritage across the biological sciences, including association with three Nobel laureates (Peter Medawar, Niko[…]

An interview with Alejandro Sánchez Alvarado

Posted by on September 11th, 2013

Alejandro Sánchez Alvarado is an investigator at the Stowers Institute and Howard Hughes Medical Institute, and has worked for many years on regeneration in a little flatworm- the planaria. The Node interviewed Alejandro at the 2013 International Society of Developmental Biology meeting, and asked him about his career, his work on regeneration, and his role[…]

In Development this week (Vol. 138, Issue 17)

Posted by on August 9th, 2011

Here are the highlights from the current issue of Development: Human embryos make an early transcriptional start Human preimplantation development is a highly dynamic process that lasts about 6 days. During this time, the embryo must complete a complex program that includes activation of embryonic genome transcription and initiation of the pluripotency program. Here, Juan[…]