Everyone knows that humans have 23 pairs of chromosomes. But back in the 1930s, the correct answer would have been 24. So what happened?
Here are the highlights from the current issue of Development: Mutant Xist merely muffles X chromosome In XX female mammals, inactivation of one X chromosome during development equalises the levels of X-linked gene products in females with those in males. Expression of the Xist gene from one of the two X chromosomes produces a non-coding[…]
Here are the research highlights from the current issue of Development: FatJ keeps neural progenitor pools in shape The correct development and functioning of the spinal cord depends on the patterning, proliferation and differentiation of neural progenitor cell cohorts along the dorsoventral axis of the neural tube. But how are the numbers of these cells[…]
Boning up on stem cell Igf2-P2 function The insulin-like growth factor (IGF)/insulin signalling pathway regulates cell proliferation, differentiation, aging and life span. During embryonic development, transcription of the mouse and human Igf2 gene is tightly regulated by four alternative promoters whose specific roles are unclear. Now, Sylvie Nathalie Hardouin and colleagues reveal that the transcriptional[…]