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PhD in nerve/tumor interactions and nervous system development

Posted by on June 18th, 2018

Applications are invited from highly motivated individuals dedicated to peruse a PhD and who are interested in nerve/tumour interactions and nervous system development.    PROJECT DESCRIPTION During tumour progression nerves and tumours interact resulting in tumour cells using nerves as a metastatic route out of the organ, through a process called perineural invasion (PNI). While this[…]

Postdoctoral Positions – RNA pathways in development and disease – NIH/NCI

Posted by on April 19th, 2018

We have open postdoctoral positions in our lab. We are looking for researchers interested in understanding the mechanisms through which non-coding RNAs and RNA metabolic pathways regulate gene expression in mammals and how these mechanisms impact animal development and disease. Our lab uses a combination of mouse models and genetic tools together with biochemical and[…]

Genes activated in metastasis also drive the first stages of tumour growth

Posted by on February 19th, 2018

In spite of the difference between the cell functions responsible for giving rise to a tumour and for the metastasis of this same tumour, studies at IRB Barcelona using the fly Drosophila melanogaster reveal that some genes can drive both phenome na.   In cancer research, there has been a tendency to differentiate between the[…]

Postdoctoral Fellow in Neurodevelopment

Posted by on January 18th, 2018

Applications are invited from highly motivated individuals who are interested in fundamental mechanisms of neuronal migration and axon guidance. The main focus of our research is to understand the molecular and cellular mechanisms underlying the development of neural circuits using the embryonic spinal cord as a model system (http://www.ucmm.umu.se/english/research/sara-wilson/). The fellowship is funded for two[…]

Two fully-funded PhD positions in Wnt trafficking at the LSI in Exeter

Posted by on October 9th, 2017

The process of subdividing a tissue into functional units represents a classic problem in pattern formation. Signalling proteins – so-called morphogens – orchestrate this process. The traditional view is that morphogens are released from local source and slowly diffuse through a neighbouring tissue to build up a gradient. As Wnt signals act as a key[…]

Internal mechanism found to be responsible for the limitless growth potential of epithelial tumours

Posted by on September 8th, 2017

Researchers from the Development and Growth Control Laboratory at IRB Barcelona have identified the cell types and molecular mechanism responsible for the unlimited growth potential of epithelial tumours (carcinomas) and demonstrated that the growth of these tumours is independent of its microenvironment. “In epithelial tumours caused by chromosomal instability or loss of cell polarity, the[…]

Gene editing stem cells with CRISPR could help understand brain tumours

Posted by on February 14th, 2017

This report written by Justine Alford and highlighting a recent Development paper originally appeared on the CRUK Science Blog.      Over the past 12 months, the acronym CRISPR has been popping up in science news left, right and centre. And for good reason. Hailed as a revolution in genetic engineering, this molecular toolbox lets[…]

Paris – Cambridge – Paris: a Megakaryocyte story

Posted by on November 14th, 2016

The first news came as a shock: so the British Railways are not always perfectly on time? For an Italian, that was a massive cultural shock. The second one was even more surprising: English weather is not that bad; actually, it is better than Parisian weather. But still, I was unable, on the train from Paris to Cambridge, to stop thinking about how[…]

Madrid Adventure to Study Autophagy in Melanoma Stem Cells

Posted by on May 20th, 2016

I am hugely grateful to the Journal of Cell Science and the Company of Biologists for awarding me a traveling fellowship to visit the laboratory of Dr Guillermo Velasco at Complutense University in Madrid, Spain. During this visit I gained a greater understating of the skills and techniques used to manipulate autophagy regulatory pathways within[…]

Insights into the pathogenic role of UVRAG in intestinal dysplasia

Posted by on May 4th, 2016

This post highlights the approach and findings of a new research article published in Disease Models & Mechanisms: ‘Stem cell-specific endocytic degradation defects lead to intestinal dysplasia in Drosophila’. This feature was written by Elan Strange as part of a graduate level seminar at The University of Alabama (taught by DMM Editorial Board member, Prof.[…]