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Two fully-funded PhD positions in Wnt trafficking at the LSI in Exeter

Posted by on October 9th, 2017

The process of subdividing a tissue into functional units represents a classic problem in pattern formation. Signalling proteins – so-called morphogens – orchestrate this process. The traditional view is that morphogens are released from local source and slowly diffuse through a neighbouring tissue to build up a gradient. As Wnt signals act as a key[…]

Internal mechanism found to be responsible for the limitless growth potential of epithelial tumours

Posted by on September 8th, 2017

Researchers from the Development and Growth Control Laboratory at IRB Barcelona have identified the cell types and molecular mechanism responsible for the unlimited growth potential of epithelial tumours (carcinomas) and demonstrated that the growth of these tumours is independent of its microenvironment. “In epithelial tumours caused by chromosomal instability or loss of cell polarity, the[…]

Gene editing stem cells with CRISPR could help understand brain tumours

Posted by on February 14th, 2017

This report written by Justine Alford and highlighting a recent Development paper originally appeared on the CRUK Science Blog.      Over the past 12 months, the acronym CRISPR has been popping up in science news left, right and centre. And for good reason. Hailed as a revolution in genetic engineering, this molecular toolbox lets[…]

Paris – Cambridge – Paris: a Megakaryocyte story

Posted by on November 14th, 2016

The first news came as a shock: so the British Railways are not always perfectly on time? For an Italian, that was a massive cultural shock. The second one was even more surprising: English weather is not that bad; actually, it is better than Parisian weather. But still, I was unable, on the train from Paris to Cambridge, to stop thinking about how[…]

Madrid Adventure to Study Autophagy in Melanoma Stem Cells

Posted by on May 20th, 2016

I am hugely grateful to the Journal of Cell Science and the Company of Biologists for awarding me a traveling fellowship to visit the laboratory of Dr Guillermo Velasco at Complutense University in Madrid, Spain. During this visit I gained a greater understating of the skills and techniques used to manipulate autophagy regulatory pathways within[…]

Insights into the pathogenic role of UVRAG in intestinal dysplasia

Posted by on May 4th, 2016

This post highlights the approach and findings of a new research article published in Disease Models & Mechanisms: ‘Stem cell-specific endocytic degradation defects lead to intestinal dysplasia in Drosophila’. This feature was written by Elan Strange as part of a graduate level seminar at The University of Alabama (taught by DMM Editorial Board member, Prof.[…]

Researchers dig up new molecular details on “the other type” of stem cells

Posted by on March 11th, 2016

Scientists at IRB Barcelona and CSIC reveal that the combination of two molecular signals determines which cells that have already differentiated can regain their stem cell properties. Their studies on fruit flies allow for advancements in the field of regenerative medicine and a better understanding of processes involved in cancer. In a study published this[…]

From our sister journals- February 2016

Posted by on February 22nd, 2016

Here is some developmental biology related content from other journals published by The Company of Biologists.           Using the developmental biology toolkit to study cancer Aiello and Stanger review the similarities between embryogenesis and cancer progression and discuss how the concepts and techniques of developmental biology are being applied to provide insight into[…]

Scientists shed light on how cells with an incorrect number of chromosomes lead to tumour development

Posted by on February 9th, 2016

Aneuploid cells—that is to say those with an abnormal number of chromosomes—are found in most human tumours. A study conducted at IRB Barcelona on the fly Drosophila reveals how surviving aneuploid cells favour tumour development.   Barcelona, Thursday 9th February 2016.- A recent analysis of 43,205 human tumours unveiled that 68% of solid tumours are[…]

Abstract deadline fast approaching: BMP Signalling in Cancer

Posted by on January 8th, 2016

BMP Signalling in Cancer 15—17 March 2016 St. Catharine’s College, Cambridge, UK Join the Biochemical Society in exploring the mechanisms of BMP signal transduction and regulation of signalling, and discussing how genetic and epigenetic alterations result in aberrant signalling and how this leads to cancer. The BMP signalling pathway is a key therapeutic target and we[…]