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Postdoctoral Fellow in Neurodevelopment

Posted by , on 18 January 2018

Applications are invited from highly motivated individuals who are interested in fundamental mechanisms of neuronal migration and axon guidance. The main focus of our research is to understand the molecular ...
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The people behind the papers - Chloé Dominici & Alain Chédotal

Posted by , on 18 January 2018

Vertebrate brain development is characterised by cell migration, as neurons are often born far from where they need to end up. Migration is regulated by guidance cues and their receptors, ...
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The people behind the papers - Simon Lane & Keith Jones

Posted by , on 4 October 2017

Checkpoints ensure that mouse oocytes with DNA damage arrest in meiosis I, preventing non-viable embryo formation, however the mechanisms which activate this checkpoint have so far eluded researchers. This week ...
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Workshop on HREM imaging and mouse phenotyping

Posted by , on 8 August 2017

Deciphering the Mechanisms of Developmental Disorders (DMDD) is a large-scale imaging and phenotyping  programme for genetically modified mouse embryos. For embryos at E14.5, the key imaging technique is High Resolution ...
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9.5 million knockout mouse embryo images now available

Posted by , on 20 July 2017

A new set of DMDD embryo and placenta data has been released, taking our total dataset to 9.5 million images of around 1300 embryos. DMDD is a primary screen of ...
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Matching neurons to limbs: an evolutionary perspective on motor system development

Posted by , on 24 February 2017

Comment on “Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles” Neuron 93, 1–14, February 22, 2017. Alana I. Mendelsohn, Departments of Neuroscience and Biochemistry ...
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Why are geneticists measuring the webbing between mouse embryo fingers?

Posted by , on 21 February 2017

A new paper published in Journal of Anatomy shows that measuring the amount of inter-digital webbing in mouse embryos between 14 and 15 days gestation is the best way to find ...
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New phenotype dataset available for embryonic-lethal mouse knockouts

Posted by , on 1 December 2016

    This post originally appeared on Annotations, the DMDD blog.   New image and phenotype data for embryos and placentas from embryonic lethal knockout mouse lines has been made ...
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Postdoctoral Position in Signaling Mechanisms

Posted by , on 25 October 2016

Postdoctoral Position open at: Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California   An NIH-funded postdoctoral position is available to investigate the signaling functions of retinoic acid (RA) during ...
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New phenotype screen examines causes of neonatal death

Posted by , on 4 October 2016

This post first appeared on Annotations, the DMDD blog (blog.dmdd.org.uk). Around a third of targeted gene knockouts in mice are embryonic-lethal. But not all deaths occur during gestation – a ...
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