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Displaying posts with the tag: niche [Clear Filter]

Stem cell makes its own niche: the story behind the paper

Posted by on July 7th, 2018

In our recent paper published in Nature, we unravel a new mechanism of an extracellular matrix protein secreted by muscle satellite (stem) cells, thereby playing the unusual role of acting as a signaling molecule to maintain the stem cell population. Here, I share the story behind this discovery and discuss the questions related to niche[…]

Multiple stem cells, population asymmetry and position-dependent heterogeneity emerge as common features of a niche for Drosophila Follicle Stem Cells and mammalian Intestinal Stem Cells

Posted by on June 16th, 2017

A discussion of “Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling,” Nat Cell Biol, 2017. 19(5): p. 433-444.   We have recently revised the model of Follicle Stem Cell (FSC) organization in the Drosophila ovary, showing that there is a much larger population of stem cells than formerly realized, that[…]

Stem cells at home

Posted by on April 12th, 2012

We depend on our own comfort zones to keep us grounded, and stem cells are no different.  A recent paper in Development describes how the adhesion that keeps a stem cell in its niche is regulated. A stem cell’s niche is important in maintaining its long-term undifferentiated state.  A great model of stem cell niche[…]

Post-doctoral position in Drosophila hematopoiesis: deciphering the niche function

Posted by on March 20th, 2012

A 3 years post-doctoral position is immediately available in the laboratory of Michèle Crozatier and Alain Vincent, at the Centre de Biologie du Développement CNRS/Toulouse University, France. One main topic of the lab concerns Drosophila hematopoiesis, the hematopoietic niche and the plasticity of cell fates in the lymph gland (http://www-cbd.ups-tlse.fr/spip.php?rubrique53). The candidate will further explore[…]

Establishing a niche

Posted by on April 12th, 2011

If there is hope to fully understand stem cells, then the environment surrounding those stem cells must be understood too.  A recent Development paper describes important results on niche establishment in Drosophila. Stem cell niches play an important role in regulating stem cell self-renewal and differentiation.  The Drosophila testis has two populations of stem cells[…]