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Displaying posts with the tag: organoids [Clear Filter]

The people behind the papers – David Turner and Peter Baillie-Johnson

Posted by on November 6th, 2017

Embryonic patterning is dependent on the establishment of the anteroposterior (AP) and dorsoventral axes early in development. In mammals this occurs by a breaking of symmetry in the epiblast, however the molecular mechanisms controlling this process are still not fully understood. This week we feature a paper published in the latest issue of Development that[…]

The people behind the papers: Holly Voges, Enzo Porrello & James Hudson

Posted by on March 15th, 2017

The use of organoids – which can be defined as artificially grown masses of cells or tissue that resemble organs – in basic and clinical research has snowballed in recent years, providing insight into fundamental developmental processes and disease etiology. Today’s paper comes from the new Special Issue of Development devoted entirely to organoids, and reports the use of human[…]

YEN does it again

Posted by on June 29th, 2016

Last month saw the return of the Young Embryologist Network annual meeting held this year at the UCL Institute of Child Health. To settle into the long weekend, a number of us from the Briscoe Lab at the Crick Mill Hill site headed on down to central London to spend the day being inspired by[…]

Question of the month- brain organoids

Posted by on March 21st, 2016

Last week, Development announced a special issue on organoids. In vitro organogenesis is a burgeoning new field, with applications in the study of human development, drug testing and ultimately the possibility of producing functional organs in the dish that could be used for transplantation. Every new technological advance brings with it a new set of ethical issues, and[…]

Special Issue on Organoids

Posted by on March 15th, 2016

In vitro organogenesis has exploded onto the stem cell and developmental biology scene. It is now possible to make  miniaturised approximations of many different organs – known as organoids – entirely in vitro, using either pluripotent stem cells or adult tissue stem cells as starting material. Coaxed towards their fate by various signalling molecules and growth factors,[…]

An interview with Melissa Little

Posted by on March 15th, 2016

This interview first appeared in Development.   Melissa Little is a Senior Principal Research Fellow at the Murdoch Childrens Research Institute in Melbourne, Australia. Her lab has studied kidney development and regeneration for over 20 years, recently making notable advances in the generation of kidney organoids from human iPSCs. We chatted with Melissa about her career,[…]

Editorial- Closing the circle: from organoids back to development

Posted by on March 15th, 2016

This editorial was written by Melissa Little and first appeared in Development.   Organogenesis is an inherently fascinating developmental process. It requires the creation of complex form and function from a collection of distinct cell types, all of which come together without a template. To achieve this, cells within the developing organ undergo differentiation, migration,[…]

Organ Design 101: Discovering the rules for building a pancreas

Posted by on November 19th, 2015

As we develop from wads of cells to fully formed humans, each of our organs goes through intricate processes to achieve the right combination and number of cells arranged in the proper way. Research published in PLoS Biology by Yung Hae Kim and her colleagues looks at the development of our hormone-oozing pancreas, which assists[…]

EuroStemCell newsletter May 2015: partners in focus

Posted by on June 3rd, 2015

EuroStemCell is a project funded by the EU that aims to help European citizens make sense of stem cells. It’s now in its third iteration, and has many more partners this time around. One of the benefits of this is more stories to tell – of interesting research happening all over Europe. This month we have lots of[…]

From our sister journals- May 2015

Posted by on May 19th, 2015

Here is some developmental biology related content from other journals published by The Company of Biologists.       Xenopus as a developmental model of neuroblastoma Neuroblastoma (NB) is a paediatric form of cancer derived from the sympathetic nervous system. Recent genome-wide sequencing data suggest that often NB does not have a clear genetic cause,[…]