the community site for and by developmental biologists

Displaying posts with the tag: placenta [Clear Filter]

9.5 million knockout mouse embryo images now available

Posted by on July 20th, 2017

A new set of DMDD embryo and placenta data has been released, taking our total dataset to 9.5 million images of around 1300 embryos. DMDD is a primary screen of embryonic lethal knockout mice, and all data can be freely accessed at dmdd.org.uk. Detailed phenotypes are available for embryos from 73 different knockout lines, and[…]

New phenotype dataset available for embryonic-lethal mouse knockouts

Posted by on December 1st, 2016

    This post originally appeared on Annotations, the DMDD blog.   New image and phenotype data for embryos and placentas from embryonic lethal knockout mouse lines has been made available on the DMDD website today. The knockout data includes the ciliary gene Rpgrip1l as well as Atg16l1, a gene encoding a protein that forms[…]

Application of Fucci technology to analysis of endoreplicating cells

Posted by on November 18th, 2013

Endoreplication (endoreduplication or endomitosis) is the process by which a cell undergoes successive rounds of DNA replication without an intervening mitosis and its accompanying cytokinesis. Developmentally programmed endoreplication causes differentiating cells, such as TGCs and megakaryocytes (MKCs), to become highly polyploid. Our recent study published in Development (Sakaue-Sawano et al., 2013) comparatively characterized endoreduplication (TGCs)[…]