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Displaying posts with the tag: reprogramming [Clear Filter]

Silencing transposons during epigenetic reprogramming

Posted by on November 8th, 2017

Molecules called endosiRNAs help us avoid genetic chaos, according to a new study from a team at the Babraham Institute. Much of the human genome contains pieces of DNA called transposons, a form of genetic parasite. When active, transposons can damage genes so it is important to keep them inactive. At a certain point early[…]

Laboratory Research Scientist

Posted by on September 20th, 2017

OVERVIEW   We are seeking a highly motivated and collaborative Laboratory Research Scientist in the area of human embryology and stem cell biology to join Dr. Kathy Niakan’s laboratory. The lab has identified several signalling pathways that may be operational in the human embryo to regulate the establishment or maintenance of pluripotent epiblast progenitor cells[…]

An interview with John Gurdon

Posted by on May 4th, 2017

On a bright, cold morning at the beginning of March, I went back to the institute I once worked in to interview the man after whom the place was named. Greeting me at the entrance, John Gurdon apologised for being a little late and asked if it was alright to delay the interview for five minutes[…]

Revisiting the classics: coupling embryology with genomics to alter cell fate

Posted by on July 13th, 2016

Comment on “Reprogramming of avian neural crest axial identity and cell fate“, Science 352, 1570-1573, (2016). Marcos Simoes-Costa, Department of Molecular Biology and Genetics, Cornell University Marianne Bronner, Division of Biology and Biological Engineering, California Institute of Technology   In the 19th century, most embryologists (i.e. precursors to developmental biologists) accepted the germ layer theory[…]

The SDB-BSDB Interview Chain: Wendy Gu interviews Valeria Yartseva

Posted by on August 11th, 2015

Wendy Gu was the winner of this year’s British Society for Developmental Biology (BSDB) meeting poster competition. Her prize was to attend the annual meeting of the Society for Developmental Biology (SDB), which took place in Snowbird, Utah, in July. Continuing the interview chain, Wendy interviewed Valeria Yartseva, who won the poster prize at the[…]

Mouse Molecular Genetics 2013

Posted by on June 24th, 2013

Mouse Molecular Genetics 18-21 September 2013 Wellcome Trust Genome Campus, Hinxton, Cambridge, UK Abstract and Bursary deadline: 19 July | Registration deadline: 7 August We are pleased to announce that the 26th annual Mouse Molecular Genetics meeting will be held at the Wellcome Trust Genome Campus, from 18 to 21 September 2013. This meeting is[…]

Regenerative Medicine: From Biology to Therapy: 30 October-1 November 2013

Posted by on March 6th, 2013

Regenerative Medicine: From Biology to Therapy 30 October-1 November 2013 Few topics in contemporary medicine have attracted more attention than stem cells and their potential for enabling the discovery of new regenerative therapies. The aim of this new Wellcome Trust Scientific Conference is to understand the biology that underpins the success or failure of regeneration,[…]

Senescent cell rejuvenation – you(r cells) are never too old for pluripotency!

Posted by on December 3rd, 2011

  In 2007, a group let by Takahashi and Yamanaka from Kyoto University successfully generated pluripotent cells from human adult fibroblasts.  They were able to induce a pluripotent state in differentiated cells by introducing four transcription factors, OCT4, SOX2, c-MYC, and KLF4 by retroviral infection, hence the name “induced pluripotent stem cells (iPSCs).”  Although the[…]

In Development This Week (Vol. 138, Issue 22)

Posted by on October 25th, 2011

Here are the highlights from the current issue of Development: The skin-healing touch of Lhx2 Skin repair after injury involves the recruitment of undifferentiated progenitor cells from nearby hair follicles (HFs) into the regenerating epidermis. The bulge and the secondary hair germ of HFs contain distinct populations of epithelial stem cells, and now Vladimir Botchkarev[…]

Conference announcement: Advances in stem cell research: Development, Regeneration & Disease in Paris, France

Posted by on January 19th, 2011

Announcement for the Advances in stem cell research: Development, Regeneration & Disease conference at the Pasteur Institute, Paris, April 6-8, 2011.