the community site for and by developmental biologists

Displaying posts with the tag: shh [Clear Filter]

Postdoctoral position – MRC Department of Biomedical/Developmental Genetics, University of Sheffield, UK

Posted by on October 26th, 2011

Overview The Research Associate will work in the MRC Centre for Developmental and Biomedical Genetics within the Department of Biomedical Science.  The department has an active community of researchers specialising in different aspects of developmental biology.  You will take part in a project aiming to understand how cell proliferation is temporally integrated with digit patterning[…]

In Development this week (Vol. 138, Issue 1)

Posted by on December 7th, 2010

The first issue of 2011 is out now…here are the highlights: Geminin control of lineage commitment The transition between pluripotency and multi-lineage commitment during early embryogenesis must be closely regulated to ensure correct spatial and temporal patterning of the embryo. But what regulates this crucial transition? According to Kristen Kroll and co-workers, part of the[…]

In Development this week (Vol. 137, Issue 24)

Posted by on November 23rd, 2010

Pak1-ing a punch in lumen formation The generation and maintenance of correct lumen size and shape is essential for the function of tubular organs. Now, Monn Monn Myat and co-workers report that p21-activated kinase (Pak1) plays a novel role during lumen formation in Drosophila embryonic salivary glands (see p. 4177). The researchers show that Pak1[…]

In Development this week (Vol. 137, Issue 23)

Posted by on November 9th, 2010

The current issue of Development is now online! Here are the research highlights: Klf5: a multifaceted regulator of cell fate Kruppel-like transcription factors (Klfs) induce and maintain pluripotency in embryonic stem cells (ESCs), and Klf4 is one of the factors used to create reprogrammed iPS cells. The role of Klfs in the specification of the[…]

In Development this week (Vol 137, Issue 20)

Posted by on September 28th, 2010

A fateful look at early mouse lineage specification The first cell lineages specified in the mouse embryo are the trophectoderm (TE), which generates the embryonic portion of the placenta, and the inner cell mass (ICM). The ICM subsequently forms the pluripotent epiblast (EPI, which produces the embryo) and the primitive endoderm (PrE, which generates other[…]

Of White and Ancient Feathers

Posted by on August 9th, 2010

I’ve just come back from a lab retreat in a country house in Sussex, UK. The weather was good and we had our scientific sessions, ranging from discussions on Sonic Hedgehog signaling in the neural tube to the latest super-resolution imaging techniques, outdoors in the courtyard. However, every once in a while, we would be[…]