the community site for and by developmental biologists

Displaying posts with the tag: x-inactivation [Clear Filter]

Genetics Unzipped podcast: The case of the missing chromosomes

Posted by on May 8th, 2019

Everyone knows that humans have 23 pairs of chromosomes. But back in the 1930s, the correct answer would have been 24. So what happened?

In Development this week (Vol. 138, Issue 13)

Posted by on June 7th, 2011

Here are the highlights from the current issue of Development: Mutant Xist merely muffles X chromosome In XX female mammals, inactivation of one X chromosome during development equalises the levels of X-linked gene products in females with those in males. Expression of the Xist gene from one of the two X chromosomes produces a non-coding[…]

In Development this week (Vol. 138, Issue 10)

Posted by on April 26th, 2011

Here are the research highlights from the current issue of Development: FatJ keeps neural progenitor pools in shape The correct development and functioning of the spinal cord depends on the patterning, proliferation and differentiation of neural progenitor cell cohorts along the dorsoventral axis of the neural tube. But how are the numbers of these cells[…]

In Development this week (Vol. 138, Issue 2)

Posted by on December 21st, 2010

Boning up on stem cell Igf2-P2 function The insulin-like growth factor (IGF)/insulin signalling pathway regulates cell proliferation, differentiation, aging and life span. During embryonic development, transcription of the mouse and human Igf2 gene is tightly regulated by four alternative promoters whose specific roles are unclear. Now, Sylvie Nathalie Hardouin and colleagues reveal that the transcriptional[…]