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This Month on the Node – August 2012

Posted by on August 31st, 2012

A detailed view of mice and fish Michael Wong wrote about the 3D mouse embryo atlas he has worked on. The high-resolution atlas of an E15.5 mouse embryo allows for easier phenotyping of mutant strains, which can then be compared to the wildtype. “If you have two groups of mouse embryos, one wild-type and one[…]

The in silico metamorphosis of the best known metazoan GRN

Posted by on August 31st, 2012

This rather lengthy summary describes a fascinating progress in the field of GRN modeling; it is a review of the article “Predictive computation of genomic logic processing functions in embryonic development”, which appeared few days ago in PNAS. Gene regulatory networks (GRNs) are complex systems of interacting genes that deploy in both space and time[…]

Public profiles on the Node

Posted by on August 30th, 2012

When you click on an author’s name on a Node post, you are currently shown a page with all of the posts by that author. You can try it on this post. In a few weeks, this is going to change! We will soon have profile pages for everyone who has written (or will write)[…]

Development: Past, Present and Future

Posted by on August 29th, 2012

    To celebrate our 25th Anniversary (see here for some memories of the last quarter century of the journal), and to look forward to the next 25 years, Development is hosting a one day symposium in Cambridge on October 25th 2012. We’ve got a great line-up of speakers, and we’ll also be holding a[…]

Flow Cytometry Core Facility Manager

Posted by on August 23rd, 2012

The Wellcome Trust-Medical Research Council Stem Cell Institute provides outstanding scientists with the opportunity to undertake ground-breaking research into the fundamental properties of mammalian stem cells. The Institute offers a comprehensive flow cytometry service to its members. The facility comprises MoFlo and FACSAria l cell sorters, Cyan and LSR-Fortessa analysers, and associated flow cytometry equipment.[…]

“You have problems with gene regulation, you say?” “Then get rid of the genes!”

Posted by on August 23rd, 2012

The purpose of this summary is to present to “The Node” readers a recent update to the story which, in my opinion, is a quite interesting example of the phenomenon of programmed genome rearrangement (PGR) that occurs in the lamprey Petromyzon marinus. Programmed genome rearrangement describes the regulated structural changes in the genome, which result[…]

In Development this week (Vol. 139, Issue 18)

Posted by on August 21st, 2012

Here are the highlights from the current issue of Development:   Retinoic acid’s developmental role illuminated The role of all-trans retinoic acid (RA) in hindbrain development and other developmental processes is usually studied by blocking endogenous RA synthesis and then continuously supplying exogenous RA by soaking embryos in all-trans RA or by implanting RA-soaked beads.[…]

Virtual nanoscopy

Posted by on August 21st, 2012

Let’s take a very close look at the inside of a fish! A recent paper in the Journal of Cell Biology describes a technique for generating large, composite, images from electron microscopy data. Frank Faas, Raimond Ravelli, and colleagues at the Leiden University Medical Center developed a method to computationally collect and align EM images.[…]

The SDB-BSDB Interview Chain: Stephen Fleenor interviews John Young

Posted by on August 16th, 2012

A few months ago, we published an interview with Stephen Fleenor, who won the poster award at the BSDB meeting. He won attendance to the SDB meeting in Montreal, where he passed on the baton and interviewed the winner of the SDB poster prize, John Young: Stephen Fleenor: In which lab do you work? John[…]

Santa Cruz Developmental Biology Meeting

Posted by on August 15th, 2012

I’ve just returned from this year’s Santa Cruz Developmental Biology meeting. Some of you may have seen the tweets I was sending out from there (see Storify for the collected set), but a combination of limited ability to multitask and limited laptop battery life meant I didn’t cover all the talks. So to add to[…]