June in preprints

In this new feature, we conduct a trawl for preprints to find the latest developmental biology and related research from the previous month.

Scientists are increasingly using preprints as a way of releasing research to the community without having to wait for the peer review process, and we want to promote this content here. Several sites host biology preprints, most notably bioRxiv, but also arXiv, f1000 Research, and PeerJ Preprints (for more info on preprints, ASAPbio has a useful FAQ page).

This month we found content from bioRxiv, arXiv, F1000 Research and PeerJ spanning developmental biology research, including investigations into cell fate in preimplantation mouse embryos and worm larvae,  a new technique for bi-allelic gene knockouts, and a method for making midbrain-specific organoids.

Developmental Biology

• Networks that link cytoskeletal regulators and diaphragm proteins underpin filtration function in Drosophila nephrocytes. Simi Muraleedharan, Helen Skaer, Maneesha S Inamdar
• Drosophila sensory cilia lacking MKS-proteins exhibit striking defects during development but only subtle defects in adults. Metta B. Pratt, Joshua S. Titlow, Ilan Davis, Amy R. Barker, Helen R. Dawe, Jordan W. Raff, Helio Roque
• A Facilitated Diffusion Mechanism Establishes the Drosophila Dorsal Gradient. Sophia N Carrell, MIchael D O’Connell, Amy E Allen, Stephanie MSmith, Gregory Reeves
• KIF1A/UNC-104 transports ATG-9 to regulate neurodevelopment and autophagy at synapses. Andrea K.H. Stavoe, Sarah E. Hill, Daniel A. Colón-Ramos
• Antagonistic roles of Polycomb repression and Notch signaling in the maintenance of somatic cell fate in C. elegans. Ringo Pueschel, Francesca Coraggio, Alisha Marti, Peter Meister
• Dynamic changes in Sox2 spatio-temporal expression direct the second cell fate decision through Fgf4/Fgfr2 signaling in preimplantation mouse embryos. Tapan Kumar Mistri, Wibowo Arindrarto, Wei Ping Ng, ChoayangWang, Hiong Lim Leng, Lili Sun, Ian Chambers, ThorstenWohland, Paul Robson
• Kinetochore Microtubules indirectly link Chromosomes and Centrosomes in C. elegans Mitosis. Stefanie Redemann, Johannes Baumgart, Norbert Lindow,Sebastian Fuerthauer, Ehssan Nazockdast, Andrea Kratz, SteffenProhaska, Jan Brugues, Michael Shelley, Thomas Mueller-Reichert
• Probing cytoplasmic viscosity in the confined geometry of tip-growing plant cells via FRAP. James L Kingsley, Jeffrey P Bibeau, Zhilu Chen, Xinming Huang,Luis Vidali, Erkan Tuzel
• RNase reverses segment sequence in the anterior of a beetle egg (Callosobruchus maculatus, Coleoptera). Jitse Michiel van der Meer
• Brachiopods possess a split Hox cluster with signs of spatial, but not temporal collinearity. Sabrina M. Schiemann, Jose M. M. Martin-Duran, Aina Borve,  Bruno C. Vellutini, Yale J. Passamaneck, Andreas Hejnol
• Nanog fluctuations in ES cells highlight the problem of measurement in cell biology. Rosanna C G Smith, Patrick S Stumpf, Sonya J Ridden, AaronSim, Sarah Filippi, Heather Harrington, Ben D MacArthur
• Trace elements during primordial plexiform network formation in human cerebral organoids. Rafaela C Sartore, Simone C Cardoso, Yuri V Lages, Julia M Paraguassu, Rodrigo F Madeiro da Costa, Marilia ZP Guimarães, Carlos A Pérez, Stevens K Rehen

Techniques

• Rapid, one-step generation of biallelic conditional gene knockouts. Bon-Kyoung Koo, Amanda Andersson-Rolf, Roxana C. Mustata,Alessandra Merenda, Sajith Perera, Tiago Grego, Jihoon Kim, KatieAndrews, Juergen Fink, William C. Skarnes
• A novel approach to derive human midbrain-specific organoids from neuroepithelial stem cells. Anna Sophia Monzel, Lisa Maria Smits, Kathrin Hemmer, SihamHachi, Edinson Lucumi Moreno, Thea van Wuellen, Ronan MTFleming, Silvia Bolognin, Jens Christian Schwamborn

Disease modelling

• Zika Virus in the Human Placenta and Developing Brain: Cell Tropism and Drug Inhibition. Hanna Retallack, Elizabeth Di Lullo, Carolina Arias, Kristeene A.Knopp, Carmen Sandoval-Espinosa, Matthew T. Laurie, Yan Zhou,Matthew Gormley, Walter R. Mancia Leon, Robert Krencik, Erik M. Ullian, Julien Spatazza, Alex A. Pollen, Katherine Ona, Tomasz J.Nowakowski, Joseph L. DeRisi, Susan J. Fisher, Arnold R. Kriegstein
• Hipk is required for JAK/STAT activity and promotes hemocyte-derived tumorigenesis. Jessica A. Blaquiere, Nathan B. Wray, Esther M. Verheyen

In silico modelling

• The Evolutionary Trade-off between Stem Cell Niche Size, Aging, and Tumorigenesis.  Vincent L. Cannataro, Scott A. McKinley, Colette M. St. Mary
• Conditions for cell size homeostasis: A stochastic hybrid systems approach. César Augusto Vargas-García, Mohammad Soltani, Abhyudai Singh
• Collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition. Simon Kaspar Schnyder, Yuki Tanaka, John Jairo Molina, Ryoichi Yamamoto

Science Communication

• Not Communicating science? Aiming for national impact. Andreas Prokop and Sam Illingworth

Is there anything we missed for June? Anything in the list that catches your eye? Let us know in the comments section.

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