Postdoc position available at the Institute of Translational Stem Cell Research (ITS)

At our institute, you will find a scientifically stimulating international environment. Together with renowned scientists and supported by an excellent infrastructure you will have the opportunity to make an important contribution to a healthier society.

The Institute of Translational Stem Cell Research (ITS), headed by Prof. Henrik Semb, focuses on developing stem-cell-based therapies to treat patients with Type 1 Diabetes. ITS is looking for an enthusiastic post-doctoral candidate with a strong background in stem cell biology to generate a human stem cell-based therapy for type 1 diabetes as part of a collaborative H2020 project, the ISLET. The goal of the ISLET project is to pioneer a new advanced cell therapy to treat T1D patients. To accomplish this, ISLET gathers a team of internationally leading experts to establish a GMP-compliant manufacturing program based on improved and standardized protocols for the generation and characterization of future stem-based based therapies.

The candidate is expected to establish a highly efficient and robust GMP-compliant manufacturing protocol for a human pluripotent stem-cell-derived beta-cell product with functional properties comparable to human islets. The GMP-compliant protocol will involve translating basic research discoveries in islet fate decisions from Prof. Semb´s lab at DanStem, University of Copenhagen.

Specifically, the candidate will participate in the generation of cell banks using a GMP-grade hESC line and a quality control strategy for the stem cell-derived beta product. Also, the candidate will produce stem-cell-derived beta cells under Good manufacturing practices (GMP) conditions in collaboration with the academic GMP-facility TUMCells. The candidate will work closely with a team of scientists at the Helmholtz Diabetes Center, an interdisciplinary and translational research centre dedicated to diabetes research, with TUMCells and with the partners of the ISLET project.

Your qualifications

• A PhD in stem cell biology/ developmental biology
• Experience in human pluripotent stem cell maintenance and differentiation
• Experience with a 3D culture of pluripotent stem cells
• Experience with flow cytometry, cell and molecular biological methods, confocal microscopy
• Experience in differentiation towards pancreatic lineage is a plus
• Experience with animal work is a plus
• Knowledge of CRISPR/Cas9 gene editing is a plus

Please visit: https://jobs.helmholtz-muenchen.de/jobposting/fa6580fab6af4200608947f02a891af7b6858b370?ref=homepage

to submit your application.