PhD and Postdoc positions in Transposon and Cancer Epigenetics Group

We are looking for talented and enthusiastic candidates fascinated by transposon and cancer biology. Fully funded PhD studentship and postdoc positions are available at the Barts Cancer Institute, Queen Mary University of London (QMUL) under the supervision of Dr Özgen Deniz to work on “The Roles of Transposable Elements as Oncogenic Regulators in Acute Myeloid Leukaemia”.

A major area of CRUK-funded research in our lab is to investigate the oncogenic roles of transposable elements in both adult and paediatric acute myeloid leukaemia. Using cell line models and primary patient samples, the candidates will investigate how epigenetic mechanisms regulate transposon activities and how disruption of epigenetic control in leukaemia favours the oncogenic activation of transposons. Combining CRISPR-based genome and epigenome editing with genomics analyses, we seek to understand how transposable elements are dysregulated in cancer and how this contributes to generation and development of cancer. By focusing on a previously understudied but important part of the genome, we hope to provide novel insights into cancer biology and uncover new determinants of oncogenic regulators that will contribute to development of new strategies in cancer therapies.

Our group employs state-of-the-art molecular and cellular biology techniques, including ATAC-seq, ChIP-seq, CUT&RUN/CUT&Tag, RNA-seq (single-cell and bulk levels), oxBS-seq, PCHi-C; high throughput CRISPRi/a screens; CRISPR-mediated genetic and epigenetic editing in cell lines and primary cancer cells.

Candidate Background

PhD position: Essential requirements for this post include an undergraduate degree in a biological subject and research laboratory experience in general molecular and cellular biology techniques. Holding a Master’s degree in a related subject will be an advantage. The candidate will have excellent academic skills (at least a 2.1 honours degree or equivalent undergraduate degree) combined with strong communication and interpersonal skills.

Postdoc position: Essential requirements includes a PhD (or be close to completion) in Molecular Biology, Life Sciences or a related discipline and an undergraduate degree in a biological subject. Significant research laboratory experience in general molecular and cellular biology techniques (qPCR, molecular cloning, mammalian cell culture) is essential. Experience in genomics techniques (ATAC-seq, ChIP-seq, CUT&RUN/CUT&Tag, RNA-seq), computational analyses of genomic data would be an advantage. A demonstrated ability to communicate well, work within a team and maintain good laboratory records are also essential. The post holder must be organised, highly self-motivated and have excellent communication and interpersonal skills. They will need to manage their time and performance, must be strongly proactive, knowledgeable, and able to solve complex problems. The post holder will be expected to prepare manuscripts using high-quality data, make oral presentations and help supervise postgraduate and graduate students.

Funding availability:

The CRUK PhD studentship includes a non-taxable stipend (£21,000/year), running expenses and university fees at UK level. Non-UK applicants will need to secure additional funding for overseas student fees. The CRUK-funded postdoc is for three years and offers a competitive salary of £35,775/year. The expected start date is January 2023 (with some flexibility).

About Queen Mary

Queen Mary’s commitment to our diverse and inclusive community is embedded in our appointments processes. Reasonable adjustments will be made at each stage of the recruitment process for any candidate with a disability. We are open to considering applications from candidates wishing to work flexibly.

For further information about our lab please visit denizlab.org. If you are interested in joining us, please send a CV, a letter of motivation (including a description of your research interests and experience) and contact information of three references by  e-mail to ozgendenizlab@gmail.com by 1^st December 2022 (PhD position) and 20^th November (postdoc position).  Informal inquiries are welcome.