Applications are invited from highly motivated and enthusiastic individuals for a BBSRC DTP funded PhD position in the laboratory of Dr. Raman Das at the Faculty of Biology, Medicine and Health at the University of Manchester. This position will commence in September 2017.
This project builds on our recent discovery of a new form of cell sub-division (apical abscission) that regulates shedding of the apical tips of newborn neurons, leading to an acute loss of cell polarity (Das and Storey, Science, 2014). How these neurons re-establish their polarity and subsequently extend an axon in the correct orientation is now a key question in the field. This project will focus on the role of the apical Par polarity complex in re-establishment of polarity in the new-born neuron using a highly interdisciplinary approach integrating pioneering cell and developmental biology techniques with powerful quantitative Mass Spectrometry-based proteomics. The successful candidate will utilise cutting-edge live-tissue imaging techniques complemented by super-resolution microscopy to visualise the fine cellular architecture of differentiating neurons. Quantitative proteomics approaches will then be employed to identify novel molecular determinants that influence neuron repolarisation.
Overall, this highly interdisciplinary project represents an ideal opportunity for advanced training in modern cell and developmental biology techniques. As this project lies at the critical interface between cell and developmental biology it is therefore also likely to provide physiologically relevant insights into the molecular mechanisms leading to neuron polarisation and axon extension.
For further details and information on how to apply visit the University of Manchester DTP studentships website at http://www.dtpstudentships.ls.manchester.ac.uk/
Deadline for applications: 18th of November 2016
Informal enquiries are encouraged and should be directed to Dr Raman Das at firstname.lastname@example.org.