Post Doctoral Fellowship(s)

‘Deciphering the link between adhesion and pluripotency,”

University of Copenhagen, Denmark

The Danish Stem Cell Center (http://danstem.ku.dk/) is seeking one or two postdoctoral fellow(s) to join the Brickman Lab/DanStem & Michael Lund Nielsen Lab/Centre for Protein Research (CPR)

The post-doctoral positions will initially be supported by a grant from the Lundbeck Foundation and seek to probe the link between pluripotency and cell-cell adhesion. They will follow up recent observations on that focus the gene regulatory network (GRN) sustaining pluripotency on adhesion. The first project, based in the Brickman lab, will follow up the means by which the GRN regulates adhesion and the second, in the Nielsen lab, will focus on deciphering the nature of the adherns junction complex in pluripotent vs differentiating cells

Project description

Embryonic Stem Cells (ESCs) are genetically normal, immortal cell lines with the capacity to become any cell type in the future organism. This project will explore the role of cell-cell adhesion supporting a pluripotent state, both in vivo and in vitro. We recently found that the evolutionarily conserved gene rergulatory network (GRN) downstream of one of the central pluripotency regulators, Oct4, was primarily concerned with regulating cell-cell adhesion (Livigni et al Curr Biol. 2013). Moreover, we found that force expression of E-cadherin could partially block differentiation in response to reduced Oct4 levels in both ESCs and embryos.  These projecst will follow up these observations on at a transcriptional and post-transcriptional level, using a combination of genetic models and mass spectrophotometry.

Qualifications

• Candidates should have experience in embryonic stem cells, developmental biology (mouse and Xenopus) or mass spectrophotometry
• Must be eligible for and prepared to write fellowship applications with in 12 months of being in the laboratory
• Experience with bio-informatics would be considered an advantage

Terms of salary, work, and employment

The employment is for 3 years and is scheduled to start October 1^st or upon agreement. Place of work: DanStem and CPR, University of Copenhagen, Blegdamsvej 3B, Copenhagen. Terms of employment are in accordance with the collective agreement between the Danish Government and the Danish Confederation of Professional Associations

Questions Contact professor Joshua Brickman; Joshua.brickman@sund.ku.dk

Application must include:

• Motivation letter

• Curriculum vitae incl. education, experience, previous employments, language skills and other relevant skills

• Copy of diplomas/degree certificate(s)

• Other information for consideration, e.g. list of publications (if any), letters of recommendationThe University of Copenhagen welcomes applications from all qualified candidates regardless of personal backgroundHow to apply:

• The application, in English, must be submitted electronically. Go to: http://danstem.ku.dk/join/jobs/

The application will be assessed according to the Ministerial Order no. 284 of 25 April 2008 on the Appointment of Academic Staff at Universities

Application deadline: July 10^th 2016

Only applications received in time and consisting of the above listed documents will be considered

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