Closing Date: 15 March 2021
Two Postdoctoral positions are immediately available at the University of California, San Francisco (UCSF), in the laboratory of Sarah Knox.
Position 1: The applicant will be part of an NIH-funded investigation into the development, regeneration and aging of exocrine organs including salivary glands, pancreas and ocular organs. The project specifically focuses on nerve-stem cell communication and how these interactions govern organ morphology, homeostasis and regeneration throughout the lifetime of the organism. In addition to defining key mechanisms regulating organogenesis, we pay particular attention to the impact of aging on organs and their potential for rejuvenation by employing parabiosis based methods in combination with 3D imaging, deep sequencing (scRNA and bulk RNA), and mouse genetics (including CRISPR generation of mouse models).
Position 2: The successful applicant will be part of an NIH-funded, pre-clinical investigation to develop a novel therapy that restores ocular and exocrine gland function through modulation of immune-nerve-epithelial cell interactions. The candidate will use genetic mouse models of autoimmune disease in conjunction with ex vivo and in vitro systems to study the effects of inflammation on epithelial cell-nerve interactions in the cornea and other ocular organs.
For both positions, applicants with a strong background in developmental biology, stem cell biology, neuroscience, mouse genetics and/or immunology are preferred. Technical expertise in the areas of mouse handling and dissection, immunoassays, immunohistochemistry, adoptive transfer, flow cytometry, qPCR, RNAseq, bioinformatics, and confocal microscopy are a plus. Applicants must possess an M.D., Ph.D., or equivalent degree. The candidate should have the proven ability to independently design and execute experiments, as well as interpret and publish results. They should also possess excellent communication skills and the ability to work as part of a team.
To apply, submit a C.V., a cover letter with a brief description of research interests and experience, and the names of at least 3 references via email: firstname.lastname@example.org